๋งˆ์นด ๋ฟŒ๋ฆฌ๋ž€?

ํŽ˜๋ฃจ ์ธ์‚ผ์œผ๋กœ๋„ ๋ถˆ๋ฆฌ๋Š” ๋งˆ์นด๋Š” ๋‚จ๋ฏธ ํŽ˜๋ฃจ์˜ ์•ˆ๋ฐ์Šค์‚ฐ๋งฅ์—์„œ ์ž๋ผ๋Š” ์‹ญ์žํ™”๊ณผ ์ฑ„์†Œ์ž…๋‹ˆ๋‹ค. ๋งˆ์นด ๋ฟŒ๋ฆฌ๋Š” ๋นจ๊ฐ•, ๊ฒ€์ •, ๋…ธ๋ž‘, ๊ฐˆ์ƒ‰ ๋“ฑ ๋‹ค์–‘ํ•œ ์ƒ‰๊น”์„ ๋ ๋ฉฐ ์ผ๋ฐ˜์ ์œผ๋กœ ๊ฐ€๋ฃจ, ํŒ…ํฌ, ์บก์Š ํ˜•ํƒœ๋กœ ์„ญ์ทจํ•ฉ๋‹ˆ๋‹ค. ๋งˆ์นด ๋ฟŒ๋ฆฌ์—๋Š” ๋น„ํƒ€๋ฏผ, ๋ฏธ๋„ค๋ž„, ์•„๋ฏธ๋…ธ์‚ฐ, ์„ฌ์œ ์†Œ๊ฐ€ ํ•จ์œ ๋˜์–ด ์žˆ์Šต๋‹ˆ๋‹ค.

๋‹ค๋ฅธ ๊ฐ•์žฅ์ œ์ฒ˜๋Ÿผ ๋งˆ์นด ๋ฟŒ๋ฆฌ๋Š” ์ผ์ƒ์ ์ธ ํ™˜๊ฒฝ ์ŠคํŠธ๋ ˆ์Šค๋ฅผ ๊ด€๋ฆฌํ•˜๋Š” ๋ณด์ถฉ์ œ๋กœ ๋งŽ์ด ์‚ฌ์šฉ๋˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. 

ํ•˜์ง€๋งŒ ๋งˆ์นด ๋ฟŒ๋ฆฌ์—๋Š” ๋‹ค๋ฅธ ๊ฐ•์žฅ์ œ์™€ ์ฐจ๋ณ„ํ™”๋˜๋Š” ๊ณ ์œ ํ•œ ํšจ๋Šฅ๋„ ๋งŽ์Šต๋‹ˆ๋‹ค. ์ตœ๊ทผ ๋งˆ์นด ๋ฟŒ๋ฆฌ๋Š” ์—๋„ˆ์ง€ ์ฆ์ง„, ๋ฆฌ๋น„๋„(์„ฑ์š•) ์ฆ๊ฐ€, ๋ฐœ๊ธฐ๋ถ€์ „ ์™„ํ™”์™€ ๊ฐ™์€ ํšจ๋Šฅ ๋•ํƒ์— ์ธ๊ธฐ๊ฐ€ ๊ธ‰์ƒ์Šนํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ํšจ๋Šฅ์€ ์•„๋ž˜์—์„œ ์ž์„ธํžˆ ๋‹ค๋ฃจ๋„๋ก ํ•˜๊ฒ ์Šต๋‹ˆ๋‹ค.

์›์‚ฐ์ง€

ํ•™๋ช…์ด ๋ ˆํ”ผ๋””์›€ ๋ฉ”์ด์—๋‹ˆ(Lepidium meyenii)์ธ ๋งˆ์นด๋Š” ํŽ˜๋ฃจ ์•ˆ๋ฐ์Šค์‚ฐ๋งฅ์˜ ๊ณ ์›์ง€๋Œ€์—์„œ ์ž์ƒํ•˜๋Š” ์‹๋ฌผ์ž…๋‹ˆ๋‹ค. ํŽ˜๋ฃจ์˜ ์•ˆ๋ฐ์Šค ์‚ฌ๋žŒ๋“ค์€ ์ˆ˜์ฒœ ๋…„๊ฐ„ ๋งˆ์นด๋ฅผ ์‹ํ’ˆ๊ณผ ์•ฝ์žฌ๋กœ ์‚ฌ์šฉํ•ด ์™”์Šต๋‹ˆ๋‹ค. ๊ฐ•์žฅ์ œ๋Š” ์ŠคํŠธ๋ ˆ์Šค์— ๋Œ€์ฒ˜ํ•˜๋Š” ์‹ ์ฒด ๊ธฐ๋Šฅ์„ ๋•๋Š” ์‹๋ฌผ ์ถ”์ถœ๋ฌผ์„ ๋งํ•ฉ๋‹ˆ๋‹ค. 

๋งˆ์นด๋Š” ๊ฐ€ํ˜นํ•˜๊ณ  ๊ทน๋‹จ์ ์ธ ๊ธฐํ›„๋ฅผ ๊ฒฌ๋”œ ์ˆ˜ ์žˆ์–ด ํ•ด๋ฐœ 4,000m์— ๊ฐ€๊นŒ์šด ๊ณ ์ง€๋Œ€์—์„œ ์ž๋ž„ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์•ˆ๋ฐ์Šค ์‚ฌ๋žŒ๋“ค์€ ํ˜ธํก๊ธฐ ์งˆํ™˜๊ณผ ๊ด€์ ˆ์—ผ์„ ์น˜๋ฃŒํ•˜๋Š” ์•ฝ์žฌ์™€ ์‹ํ’ˆ์œผ๋กœ ์‚ฌ์šฉํ•˜๊ธฐ ์œ„ํ•ด ๋งˆ์นด๋ฅผ ์žฌ๋ฐฐํ–ˆ์Šต๋‹ˆ๋‹ค. ๋งˆ์นด๋Š” ํŽ˜๋ฃจ ์ธ์‚ผ์ด๋ผ๋Š” ์ด๋ฆ„์œผ๋กœ๋„ ๋ถˆ๋ฆฌ์ง€๋งŒ ๋ถ„๋ฅ˜ํ•™์ƒ ์ธ์‚ผ๊ณผ ๊ฐ™์€ ๊ณผ์— ์†ํ•˜์ง€ ์•Š์œผ๋ฉฐ ์•„์‹œ์•„ ์ง€์—ญ์—์„œ ์ž์ƒํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค. ํ•˜์ง€๋งŒ ๋งˆ์นด ๋ฟŒ๋ฆฌ์— ๋Œ€ํ•œ ์ˆ˜์š”๊ฐ€ ์ฆ๊ฐ€ํ•˜๋ฉด์„œ ์ค‘๊ตญ ์œˆ๋‚œ์„ฑ ์‚ฐ์•… ์ง€์—ญ์„ ๋น„๋กฏํ•ด ์ „ ์„ธ๊ณ„์—์„œ ๋Œ€๋Ÿ‰ ์žฌ๋ฐฐ๋˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค.

์„ญ์ทจ ๋ฐฉ๋ฒ•

์Šค๋ฌด๋””, ์ฃผ์Šค, ์…ฐ์ดํฌ์— ํƒ€๊ฑฐ๋‚˜ ์ปคํ”ผ, ์ดˆ์ฝœ๋ฆฟ, ์˜ค์ผ์— ์ฒจ๊ฐ€ํ•˜๋Š” ๋“ฑ ๋‹ค์–‘ํ•œ ๋ฐฉ๋ฒ•์œผ๋กœ ๋งˆ์นด๋ฅผ ์„ญ์ทจํ•ด ํšจ๋Šฅ์„ ๋ˆ„๋ฆด ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ ๋งˆ์นด๋Š” ํ™๋‚ด์Œ์ด ๋‚˜๋Š” ๋ง› ๋•Œ๋ฌธ์— ๋‹ค์–‘ํ•œ ์š”๋ฆฌ์— ์‚ฌ์šฉ๋ฉ๋‹ˆ๋‹ค.

์‚ฌ๋žŒ๋“ค ์‚ฌ์ด์— ๋Œ€์ฒด ์˜ํ•™์˜ ์ธ๊ธฐ๊ฐ€ ๋†’์•„์ง€๊ณ  ์žˆ๋Š” ๊ฐ€์šด๋ฐ ๋งˆ์นด ๊ฐ™์€ ์•ฝ์šฉ ์‹๋ฌผ๊ณผ ํ—ˆ๋ธŒ๋Š” ์ „ ์„ธ๊ณ„ ๊ณผํ•™์ž๋“ค์˜ ๋งŽ์€ ๊ด€์‹ฌ์„ ๋Œ๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ๊ทธ ๊ฒฐ๊ณผ ๋งˆ์นด ๋ฟŒ๋ฆฌ์˜ ํšจ๋Šฅ์„ ์ž…์ฆํ•˜๋Š” ๋งŽ์€ ๋™๋ฌผ ์—ฐ๊ตฌ ๋ฐ ์ž„์ƒ ์‹œํ—˜ ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์˜ค๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. 

๊ณผํ•™์ž๋“ค์€ ๋งˆ์นด์˜ ํšจ๋Šฅ์ด ๋งˆ์นด๋งˆ์ด๋“œ(Macamide), ๋งˆ์นด๋ฆฌ๋”˜(Macaridine), ์•Œ์นผ๋กœ์ด๋“œ(Alkaloid), ๊ธ€๋ฃจ์ฝ”์‹œ๋†€๋ ˆ์ดํŠธ(Glucosinolate) ๋“ฑ์˜ ํ™œ์„ฑ ์„ฑ๋ถ„ ๋•ํƒ์— ๋‚˜ํƒ€๋‚œ๋‹ค๊ณ  ์ƒ๊ฐํ•ฉ๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ํ™œ์„ฑ ์„ฑ๋ถ„์„ ํ•จ์œ ํ•˜๊ณ  ์ฒ ๋ถ„, ๋‹จ๋ฐฑ์งˆ, ๋น„ํƒ€๋ฏผC ๊ฐ™์€ ํ•„์ˆ˜ ์˜์–‘์†Œ๊ฐ€ ํ’๋ถ€ํ•œ ๋งˆ์นด๋Š” ๊ฑด๊ฐ•๊ณผ ์›ฐ๋น™์„ ํšจ๊ณผ์ ์œผ๋กœ ์ฆ์ง„ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 

์—ฐ๊ตฌ๋ฅผ ํ†ตํ•ด ์ž…์ฆ๋œ ๋งˆ์นด์˜ ํšจ๋Šฅ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค. 

1. ์„ฑ์š• ์ฆ์ง„

๋งˆ์นด ๋ฟŒ๋ฆฌ๋Š” ๋‚จ๋…€์˜ ์„ฑ์š•์„ ๋†’์ผ ์ˆ˜ ์žˆ๋Š” ํšจ๋Šฅ์œผ๋กœ ๊ฐ€์žฅ ์ž˜ ์•Œ๋ ค์ ธ ์žˆ์Šต๋‹ˆ๋‹ค. 2000๋…„์— ๋ฐœํ‘œ๋œ ํ•œ ์—ฐ๊ตฌ๋Š” ์ด๋Ÿฌํ•œ ํšจ๋Šฅ์ด ๋Œ€์ค‘์—๊ฒŒ ์•Œ๋ ค์ง„ ๊ณ„๊ธฐ๊ฐ€ ๋˜์—ˆ์„ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์ง„์€ ์‹คํ—˜์šฉ ์ฅ๊ฐ€ ๋งˆ์นด ์ถ”์ถœ๋ฌผ์„ ์„ญ์ทจํ•˜๋ฉด ์„ฑ์š•์ด ์ฆ๊ฐ€ํ•œ๋‹ค๋Š” ์‚ฌ์‹ค์„ ํ™•์ธํ–ˆ์Šต๋‹ˆ๋‹ค. ์ด ์—ฐ๊ตฌ ์ดํ›„ ๊ณผํ•™์ž๋“ค์€ ๋งˆ์นด ๋ฟŒ๋ฆฌ์˜ ์„ฑ์š• ์ฆ์ง„ ํšจ๋Šฅ์„ ์กฐ์‚ฌํ•˜๊ธฐ ์‹œ์ž‘ํ–ˆ๊ณ  ๋ช‡ ๊ฐ€์ง€ ๊ธ์ •์ ์ธ ์ฆ๊ฑฐ๋ฅผ ๋ฐœ๊ฒฌํ–ˆ์Šต๋‹ˆ๋‹ค. 2002๋…„ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งค์ผ 1.5-3g์˜ ๋งˆ์นด๋ฅผ ์„ญ์ทจํ•œ ๋‚จ์„ฑ์€ ์œ„์•ฝ๊ตฐ๊ณผ ๋น„๊ตํ•ด ์„ฑ์š•์ด ์ฆ๊ฐ€ํ–ˆ์Šต๋‹ˆ๋‹ค. 

๋˜ํ•œ CNS ์‹ ๊ฒฝ๊ณผํ•™ ๋ฐ ์น˜๋ฃŒํ•™ ์ €๋„(CNS Neuroscience and Therapeutics Journal)์— ๋ฐœํ‘œ๋œ ์—ฐ๊ตฌ์—์„œ๋Š” ํ•ญ์šฐ์šธ์ œ๋ฅผ ๋ณต์šฉํ•˜๋Š” ์—ฌ์„ฑ์ด ํ•˜๋ฃจ์— 3g์˜ ๋งˆ์นด๋ฅผ ์„ญ์ทจํ•˜๋ฉด ์„ฑ์š•๊ณผ ์„ฑ๊ธฐ๋Šฅ์ด ํฌ๊ฒŒ ๊ฐœ์„ ๋˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๋งˆ์ฐฌ๊ฐ€์ง€๋กœ ์œ„ ์—ฐ๊ตฌ ๋…ผ๋ฌธ ์ €์ž์˜ ๋‘ ๋ฒˆ์งธ ์—ฐ๊ตฌ์—์„œ๋„ ์œ ์‚ฌํ•œ ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์™”์Šต๋‹ˆ๋‹ค. ์ด ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋Š” ๋งˆ์นด๊ฐ€ ํ๊ฒฝ ํ›„ ์—ฌ์„ฑ์˜ ์„ฑ์š•์„ ํ–ฅ์ƒ์‹œํ‚ฌ ์ˆ˜ ์žˆ์œผ๋ฉฐ ํŠนํžˆ ํ•ญ์šฐ์šธ์ œ๋ฅผ ๋ณต์šฉํ•˜๋Š” ๊ฒฝ์šฐ ๋งˆ์นด๋ฅผ ์„ญ์ทจํ•˜๋ฉด ๊ทธ ํšจ๊ณผ๊ฐ€ ๋”์šฑ ๋†’์„ ์ˆ˜ ์žˆ์Œ์„ ์‹œ์‚ฌํ•ฉ๋‹ˆ๋‹ค.

2. ๊ฐ€์ž„๋ ฅ ํ–ฅ์ƒ

1970๋…„ ์ดํ›„๋กœ ์„ ์ง„๊ตญ ๋‚จ์„ฑ๋“ค์˜ ํ…Œ์Šคํ† ์Šคํ…Œ๋ก  ์ˆ˜์น˜๋Š” ์ง€์†์ ์œผ๋กœ ๊ฐ์†Œํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ํ˜„์ƒ์ด ์ƒ๊ธฐ๋Š” ์ด์œ ๋Š” ๋‚ด๋ถ„๋น„๊ต๋ž€๋ฌผ์งˆ ๋•Œ๋ฌธ์ผ ๊ฐ€๋Šฅ์„ฑ์ด ํฝ๋‹ˆ๋‹ค. ๋งˆ์ฐฌ๊ฐ€์ง€๋กœ ์ •์ž ์ˆ˜๋„ ํฌ๊ฒŒ ์ค„์–ด๋“ค๊ณ  ์žˆ๋Š” ์ถ”์„ธ์ž…๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ์ •์ž ์ˆ˜๋Š” ๋งค๋…„ ์•ฝ 1%์”ฉ ์ค„๊ณ  ์žˆ์œผ๋ฉฐ 1970๋…„๋ถ€ํ„ฐ ์ด 50-60% ๊ฐ์†Œํ•œ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ์ผ๋ถ€ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด ๋ฟŒ๋ฆฌ๋Š” ์ด๋Ÿฌํ•œ ๋ฌธ์ œ๋ฅผ ๊ฐœ์„ ํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.

2001๋…„ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด ๋ณด์ถฉ์ œ๋Š” ์ •์•ก๋Ÿ‰, ์ •์ž์˜ ์ˆ˜ ๋ฐ ์šด๋™์„ฑ์„ ์ฆ๊ฐ€์‹œํ‚ฌ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 2015๋…„ ์—ฐ๊ตฌ์—์„œ๋„ ๋งค์ผ ๋งˆ์นด๋ฅผ ์„ญ์ทจํ•œ ์‚ฌ๋žŒ์€ ์œ„์•ฝ์„ ์„ญ์ทจํ•œ ๋Œ€์กฐ๊ตฐ์— ๋น„ํ•ด ์ •์ž์˜ ์ˆ˜์™€ ์šด๋™์„ฑ์ด ํฌ๊ฒŒ ์ฆ๊ฐ€ํ•œ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ ์•ˆ๋“œ๋กœ์ง€์•„ ์ €๋„(Journal Andrologia)์— ๊ฒŒ์žฌ๋œ ๋‹ค๋ฅธ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด 12์ฃผ ๋™์•ˆ ๋งˆ์นด๋ฅผ ์„ญ์ทจํ•œ ์‚ฌ๋žŒ์€ ์œ„์•ฝ๊ตฐ๋ณด๋‹ค ์ •์•ก ๋†๋„๊ฐ€ ํฌ๊ฒŒ ๊ฐœ์„ ๋œ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. 

ํ•˜์ง€๋งŒ 2016๋…„ ๋ฌธํ—Œ ๊ฒ€ํ† ์—์„œ๋Š” ์ด๋Ÿฌํ•œ ๋งˆ์นด์˜ ํšจ๋Šฅ์— ๋Œ€ํ•œ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๊ฐ€ ๊ณ ๋ฌด์ ์ด์ง€๋งŒ ๊ฒฐ์ •์ ์ธ ์ฆ๊ฑฐ๋ฅผ ์–ป๊ธฐ ์œ„ํ•œ ์ถ”๊ฐ€ ์—ฐ๊ตฌ๊ฐ€ ํ•„์š”ํ•˜๋‹ค๊ณ  ๊ฒฐ๋ก ์ง€์—ˆ์Šต๋‹ˆ๋‹ค.

3. ๋ฐœ๊ธฐ๋ถ€์ „ ๊ฐœ์„ 

๋ฐœ๊ธฐ๋ถ€์ „์„ ๊ฒช๋Š” ์‚ฌ๋žŒ์€ ์ „ ์„ธ๊ณ„์ ์œผ๋กœ ์ˆ˜๋ฐฑ๋งŒ ๋ช…์— ๋‹ฌํ•ฉ๋‹ˆ๋‹ค. ๋ฏธ๊ตญ์˜ ๊ฒฝ์šฐ 40์„ธ์—์„œ 70์„ธ ์‚ฌ์ด์˜ ๋‚จ์„ฑ ์ค‘ ์ ˆ๋ฐ˜ ์ด์ƒ์ด ํ•œ ๋ฒˆ ์ด์ƒ ๋ฐœ๊ธฐ๋ถ€์ „์„ ๊ฒฝํ—˜ํ•ฉ๋‹ˆ๋‹ค. ์ด ๋•Œ๋ฌธ์— ๋งˆ์นด ๋ฟŒ๋ฆฌ ๋“ฑ์˜ ์ •๋ ฅ์ œ๋ฅผ ์‚ฌ์šฉํ•ด ๋” ์‹ฌ๊ฐํ•œ ๋ฌธ์ œ๋ฅผ ์˜ˆ๋ฐฉํ•˜๋Š” ๋ฐฉ๋ฒ•์ด ๊ด‘๋ฒ”์œ„ํ•˜๊ฒŒ ์‚ฌ์šฉ๋˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์ด์™€ ๊ด€๋ จํ•œ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋„ ๊ธ์ •์ ์ธ ๊ฒƒ์œผ๋กœ ๋ณด์ž…๋‹ˆ๋‹ค. 2009๋…„ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด ๋ณด์ถฉ์ œ๋Š” ๋ฐœ๊ธฐ๋ถ€์ „์ด ์žˆ๋Š” ์‚ฌ๋žŒ์˜ ์„ฑ ๊ฑด๊ฐ•์„ ํฌ๊ฒŒ ํ–ฅ์ƒ์‹œํ‚ต๋‹ˆ๋‹ค. 

2019๋…„ ์—ฐ๊ตฌ์—์„œ๋Š” ๋งˆ์นด ๋ฟŒ๋ฆฌ์™€ ์ค‘๊ตญ ์ชฝํŒŒ(๋งˆ๋Š˜ ์ชฝํŒŒ๋ผ๊ณ ๋„ ๋ถˆ๋ฆผ)์˜ ์ถ”์ถœ๋ฌผ์„ ๋ฐฐํ•ฉํ•ด ํšจ๊ณผ๋ฅผ ์กฐ์‚ฌํ–ˆ์Šต๋‹ˆ๋‹ค. ๊ทธ ๊ฒฐ๊ณผ ์ถ”์ถœ๋ฌผ์„ ๋ฐฐํ•ฉํ•˜๋ฉด ๊ฐ ์ถ”์ถœ๋ฌผ์„ ๋‹จ๋…์œผ๋กœ ์‚ฌ์šฉํ•˜๋Š” ๊ฒฝ์šฐ๋ณด๋‹ค ๋‚จ์„ฑ์˜ ์„ฑ๊ธฐ๋Šฅ์„ ๊ฐœ์„ ํ•˜๋Š” ๋ฐ ๋” ํšจ๊ณผ์ ์ธ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ 2010๋…„ ๋ฌธํ—Œ ๊ฒ€ํ† ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด๋Š” ๋‚จ์„ฑ์˜ ์„ฑ์š•์„ ๊ฐœ์„ ํ•  ์ˆ˜ ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค. ๋‹จ, ์ด ๋ฌธํ—Œ ๊ฒ€ํ† ์˜ ์ €์ž๋Š” ํ™•์ •์ ์ธ ๊ฒฐ๋ก ์„ ์–ป์œผ๋ ค๋ฉด ์—ฐ๊ตฌ๊ฐ€ ๋” ํฐ ๊ทœ๋ชจ๋กœ ์ง„ํ–‰๋˜์–ด์•ผ ํ•œ๋‹ค๊ณ  ์ง€์ ํ–ˆ์Šต๋‹ˆ๋‹ค.

 4. ๋ถˆ์•ˆ ๋ฐ ์šฐ์šธ์ฆ ์™„ํ™”

์ง€๋‚œ ์ˆ˜๋…„๊ฐ„ ๋ถˆ์•ˆ, ์šฐ์šธ์ฆ, ์ •์‹  ๊ฑด๊ฐ•์€ ์‚ฌํšŒ์ ์œผ๋กœ ํฐ ๋ฌธ์ œ๊ฐ€ ๋˜์–ด ์™”์Šต๋‹ˆ๋‹ค. ํ๊ฒฝ ์ €๋„(Journal of Menopause)์— ๋ฐœํ‘œ๋œ 2008๋…„ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ํ๊ฒฝ ํ›„ ์—ฌ์„ฑ์ด ๋งค์ผ 3.5g์˜ ๋งˆ์นด๋ฅผ ์„ญ์ทจํ•˜๋ฉด ๋ถˆ์•ˆ, ์šฐ์šธ์ฆ๊ณผ ๊ฐ™์€ ์‹ฌ๋ฆฌ์  ์ฆ์ƒ์ด ๊ฐœ์„ ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋˜ ๋‹ค๋ฅธ ์—ฐ๊ตฌ์—์„œ๋Š” ํ™์ฝฉ์˜ ํ๊ฒฝ ํ›„ ์—ฌ์„ฑ 29๋ช…์—๊ฒŒ 6์ฃผ ๋™์•ˆ ๋งค์ผ 3.3g์˜ ๋งˆ์นด ๋˜๋Š” ์œ„์•ฝ์„ ํˆฌ์—ฌํ–ˆ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ ๊ฒฐ๊ณผ ๋งˆ์นด๋ฅผ ์„ญ์ทจํ•œ ์—ฌ์„ฑ์€ ์œ„์•ฝ ์„ญ์ทจ ๊ทธ๋ฃน์— ๋น„ํ•ด ํ˜ˆ์••์ด ํ˜„์ €ํžˆ ๋‚ฎ์•„์ง€๊ณ  ์šฐ์šธ์ฆ์ด ๊ฐœ์„ ๋œ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค.

 ๋˜ํ•œ ๋งŽ์€ ๋™๋ฌผ ์—ฐ๊ตฌ์—์„œ๋„ ์ด๋Ÿฌํ•œ ํšจ๋Šฅ์ด ์ž…์ฆ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ์ผ๋ก€๋กœ 2019๋…„์˜ ๋™๋ฌผ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด ๋ณด์ถฉ์ œ๋Š” ๋ถˆ์•ˆ๊ณผ ์šฐ์šธ์ฆ์„ ์–ต์ œํ•˜๋Š” ํšจ๋Šฅ์„ ๋‚˜ํƒ€๋ƒ…๋‹ˆ๋‹ค. ๋งˆ์นด๋Š” ์ฝ”๋ฅดํ‹ฐ์†”(Cortisol) ๋“ฑ ์ŠคํŠธ๋ ˆ์Šค ํ˜ธ๋ฅด๋ชฌ์˜ ์ˆ˜์น˜์™€ ๊ฐ™์€ ์ค‘์š”ํ•œ ์ŠคํŠธ๋ ˆ์Šค ์ง€ํ‘œ๋ฅผ ๊ฐœ์„ ํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค.

5. ํ๊ฒฝ ์ฆ์ƒ ๊ฐœ์„ 

๋งŽ์€ ์—ฌ์„ฑ์—๊ฒŒ ํ๊ฒฝ๊ธฐ๋Š” ํž˜๋“  ์‹œ๊ธฐ์ผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋‹คํ–‰์Šค๋Ÿฝ๊ฒŒ๋„ ๋งˆ์นด ๋ฟŒ๋ฆฌ ๊ฐ™์€ ๋ณด์ถฉ์ œ๋Š” ํ๊ฒฝ๊ธฐ๋ฅผ ๊ฒช๊ฑฐ๋‚˜ ๊ทธ ์ดํ›„์˜ ์‹œ๊ธฐ๋ฅผ ๋ณด๋‚ด๋Š” ์—ฌ์„ฑ์—๊ฒŒ ๋งŽ์€ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด ๋ฟŒ๋ฆฌ๋Š” ์„ฑ๊ธฐ๋Šฅ ์žฅ์• ์™€ ์‹ฌ๋ฆฌ์  ์ฆ์ƒ์„ ์™„ํ™”ํ•  ๋ฟ ์•„๋‹ˆ๋ผ ์ผ๊ณผ์„ฑ ์—ด๊ฐ, ์•ผ๊ฐ„ ๋ฐœํ•œ, ์‹ ๊ฒฝ๊ณผ๋ฏผ, ์‹ฌ๊ณ„ํ•ญ์ง„, ์ˆ˜๋ฉด์žฅ์• ๋ฅผ ๊ฐœ์„ ํ•˜๋Š” ๋ฐ๋„ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.

124๋ช…์˜ ํ”ผํ—˜์ž๋ฅผ ๋Œ€์ƒ์œผ๋กœ ํ•œ 2006๋…„ ์—ฐ๊ตฌ์—์„œ ๋งˆ์นด ๋ณด์ถฉ์ œ๋Š” ํ๊ฒฝ ํ›„ ์ฆ์ƒ์„ ๊ด€๋ฆฌํ•˜๊ณ  ํ˜ธ๋ฅด๋ชฌ ๋Œ€์ฒด์š”๋ฒ•์— ๋Œ€ํ•œ ์˜์กด๋„๋ฅผ ์ค„์ด๋Š” ๋ฐ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ ๋งˆ์นด ๋ฟŒ๋ฆฌ๋Š” ํ๊ฒฝ์œผ๋กœ ์ธํ•œ ๋ถˆํŽธํ•จ์„ ์™„ํ™”ํ•˜๊ธฐ ์œ„ํ•œ ๋Œ€์•ˆ์ ์ธ ์ˆ˜๋‹จ์„ ์ฐพ๋Š” ์—ฌ์„ฑ์—๊ฒŒ ํ›Œ๋ฅญํ•œ ์„ ํƒ์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.

6. ํ•™์Šต ๋Šฅ๋ ฅ ๋ฐ ๊ธฐ์–ต๋ ฅ ํ–ฅ์ƒ

๋…ธํ™” ๋˜๋Š” ๋‹ค๋ฅธ ์ด์œ ๋กœ ์ธํ•œ ์น˜๋งค์™€ ๊ฐ™์€ ๊ธฐ์–ต ์žฅ์• ๋Š” ์ „ ์„ธ๊ณ„์ ์œผ๋กœ ์‹ฌ๊ฐํ•œ ๋ฌธ์ œ์ž…๋‹ˆ๋‹ค. ์•ˆํƒ€๊น๊ฒŒ๋„ ์ด๋Ÿฌํ•œ ์งˆํ™˜์„ ์‰ฝ๊ฒŒ ์น˜๋ฃŒํ•  ์ˆ˜ ์žˆ๋Š” ๋ฐฉ๋ฒ•์ด ์—†๊ธฐ ๋•Œ๋ฌธ์— ๋Œ€์ฒด์˜ํ•™์˜ ์ค‘์š”์„ฑ์ด ํฌ๊ฒŒ ๋ถ€๊ฐ๋˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ๋งŽ์€ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด ๋ฟŒ๋ฆฌ์™€ ๊ฐ™์€ ๊ฐ•์žฅ์ œ๋Š” ์‹ ๊ฒฝ์„ ๋ณดํ˜ธํ•˜๋Š” ํšจ๋Šฅ์ด ์žˆ์Šต๋‹ˆ๋‹ค. ๋งˆ์นด ๋ฟŒ๋ฆฌ๋Š” ํ•™์Šต ๋Šฅ๋ ฅ ๋ฐ ๊ธฐ์–ต๋ ฅ์„ ํ–ฅ์ƒ์‹œํ‚ค๋Š” ๋ฐ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 

2007๋…„ ๋™๋ฌผ ์—ฐ๊ตฌ์—์„œ๋Š” ๋งˆ์นด ๋ฟŒ๋ฆฌ๊ฐ€ ์Šค์ฝ”ํด๋ผ๋ฏผ(Scopolamine)์— ์˜ํ•œ ๊ธฐ์–ต์ƒ์‹ค์„ ์™„ํ™”ํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค. ์ด ์•ฝ๋ฌผ์€ ๋ฉ€๋ฏธ๋‚˜ ์ˆ˜์ˆ  ํ›„์˜ ๋ฉ”์Šค๊บผ์›€ ๋ฐ ๊ตฌํ† ๋ฅผ ์น˜๋ฃŒํ•˜๋Š” ๋ฐ ์ž์ฃผ ์‚ฌ์šฉ๋˜๋Š” ์•ฝ๋ฌผ์ž…๋‹ˆ๋‹ค. ์‹คํ—˜์‹ค ์ฅ๋ฅผ ๋Œ€์ƒ์œผ๋กœ ํ•œ 2011๋…„ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด ๋ฟŒ๋ฆฌ๋Š” ์—ํƒ„์˜ฌ๋กœ ์ธํ•œ ๊ธฐ์–ต์ƒ์‹ค์„ ๊ฐœ์„ ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ธ๊ฐ„์—๊ฒŒ๋„ ๋™์ผํ•œ ํšจ๊ณผ๊ฐ€ ์žˆ๋Š”์ง€๋Š” ์•„์ง ํ™•์ธ๋˜์ง€ ์•Š์•˜์Šต๋‹ˆ๋‹ค.

2016๋…„ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด๋Š” ๋…ธํ™”์— ๋”ฐ๋ฅธ ์ธ์ง€ ๊ธฐ๋Šฅ ์ €ํ•˜๋ฅผ ์–ต์ œํ•  ์ˆ˜๋„ ์žˆ์Šต๋‹ˆ๋‹ค. ํ•˜์ง€๋งŒ ์ด๋Ÿฌํ•œ ํšจ๋Šฅ์— ๋Œ€ํ•œ ํ™•์ •์ ์ธ ๊ฒฐ๋ก ์„ ๋‚ด๋ฆฌ๊ธฐ ์œ„ํ•ด์„œ๋Š” ๋Œ€๊ทœ๋ชจ ์ž„์ƒ ์—ฐ๊ตฌ๊ฐ€ ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.

7. ์—๋„ˆ์ง€ ๋ฐ ์ง€๊ตฌ๋ ฅ ๊ฐœ์„ 

์ผ๋ถ€ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด ๋ฟŒ๋ฆฌ๋Š” ํ”ผ๋กœ๋ฅผ ์™„ํ™”ํ•˜๊ณ  ์›๊ธฐ์™€ ์ง€๊ตฌ๋ ฅ์„ ํ–ฅ์ƒ์‹œํ‚ต๋‹ˆ๋‹ค. 2017๋…„ ์—ฐ๊ตฌ์—์„œ๋Š” ๋งˆ์นด ๋ฟŒ๋ฆฌ๊ฐ€ ๊ทผ์œก ๋‚ด์˜ ํ•ญ์‚ฐํ™” ์ž‘์šฉ์„ ์ด‰์ง„ํ•˜๊ณ  ์‹คํ—˜์‹ค ์ฅ์˜ ๊ทผ์œก ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ์ˆ˜์น˜๋ฅผ ํ–ฅ์ƒ์‹œํ‚ค๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๋˜ ๋‹ค๋ฅธ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด ๋ณด์ถฉ์ œ๋Š” ์ข‹์€ ์žฅ๋‚ด ๋ฐ•ํ…Œ๋ฆฌ์•„์˜ ์„ฑ์žฅ์„ ์ด‰์ง„ํ•ด ํƒ„์ˆ˜ํ™”๋ฌผ, ์ง€์งˆ, ๋‹จ๋ฐฑ์งˆ ๋Œ€์‚ฌ๋ฅผ ๊ฐœ์„ ํ•˜๊ณ  ํ•ญํ”ผ๋กœ์ œ ๊ฐ™์€ ๊ธฐ๋Šฅ์„ ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 

๋™๋ฌผ ์—ฐ๊ตฌ๋ฟ ์•„๋‹ˆ๋ผ ์ธ๊ฐ„์„ ๋Œ€์ƒ์œผ๋กœ ํ•œ ์—ฐ๊ตฌ์—์„œ๋„ ๋งˆ์นด ๋ณด์ถฉ์ œ๋Š” ๊ฑด๊ฐ•๊ณผ ๊ด€๋ จ๋œ ์‚ถ์˜ ์งˆ, ๊ธฐ๋ถ„, ์—๋„ˆ์ง€๋ฅผ ํ–ฅ์ƒ์‹œํ‚ค๋Š” ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค. 

ํฅ๋ฏธ๋กญ๊ฒŒ๋„ 2020๋…„ ๋ฌธํ—Œ ๊ฒ€ํ† ์—์„œ๋Š” ๋ชจ๋“  ๊ณ ์ง€๋Œ€ ์‹๋ฌผ์ด ์ด๋Ÿฌํ•œ ํšจ๋Šฅ์„ ๋‚˜ํƒ€๋‚ผ ์ˆ˜ ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ์ œ์‹œํ–ˆ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์ง„์€ ๋งˆ์นด์™€ ๊ฐ™์€ ๊ณ ์ง€๋Œ€ ์‹๋ฌผ์ด ๋‡Œ ์†์ƒ์„ ๋ฐฉ์ง€ํ•˜๊ณ  ์—๋„ˆ์ง€๋ฅผ ์ฆ์ง„ํ•˜๋ฉฐ ์‹ ์ง„๋Œ€์‚ฌ๋ฅผ ์กฐ์ ˆํ•˜๊ณ  ์—ผ์ฆ์„ ์–ต์ œํ•ด ํ”ผ๋กœ๋ฅผ ํ˜„์ €ํžˆ ์™„ํ™”์‹œํ‚จ๋‹ค๋Š” ์‚ฌ์‹ค์„ ๋ฐํ˜”์Šต๋‹ˆ๋‹ค. 

8. ํ”ผ๋ถ€ ๊ฐœ์„ 

๋งˆ์นด์˜ ํšจ๋Šฅ์€ ์—ฌ๊ธฐ์— ๊ทธ์น˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค. ์ผ๋ถ€ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด ๋ฟŒ๋ฆฌ๋Š” ํƒœ์–‘ ์ž์™ธ์„ ์œผ๋กœ๋ถ€ํ„ฐ ํ”ผ๋ถ€๋ฅผ ๋ณดํ˜ธํ•  ์ˆ˜๋„ ์žˆ์Šต๋‹ˆ๋‹ค. ๋งˆ์นด๋Š” ํ”ผ๋ถ€์—์„œ ์‚ฐํ™”๋ฅผ ๊ฐ•๋ ฅํ•˜๊ฒŒ ์–ต์ œํ•˜๋Š” ์ž‘์šฉ์„ ํ•ฉ๋‹ˆ๋‹ค. ๋งˆ์นด๋Š” ์„ธํฌ๋ง‰ ์†์ƒ ๋ฐ ์„ธํฌ ์‚ฌ๋ฉธ์„ ์œ ๋ฐœํ•˜๋Š” ์ง€์งˆ์˜ ์‚ฐํ™”๋ถ„ํ•ด ์—ฐ์‡„ ๋ฐ˜์‘์ธ ์ง€์งˆ ๊ณผ์‚ฐํ™”(Lipid peroxidation)๋ฅผ ๋ฐฉ์ง€ํ•ด ํ”ผ๋ถ€๋ฅผ ๋ณดํ˜ธํ•ฉ๋‹ˆ๋‹ค. ๋˜ํ•œ ๋งˆ์นด์—๋Š” ์•Œ์นผ๋กœ์ด๋“œ, ํด๋ฆฌํŽ˜๋†€(Polyphenol), ์Šคํ…Œ๋กค(Sterol)๊ณผ ๊ฐ™์€ ์˜์–‘์†Œ๋„ ํ•จ์œ ๋˜์–ด ์žˆ์Šต๋‹ˆ๋‹ค. ํƒœ์–‘๊ด‘์œผ๋กœ๋ถ€ํ„ฐ ํ”ผ๋ถ€๋ฅผ ๋ณดํ˜ธํ•˜๋Š” ๋งˆ์นด์˜ ์ด๋Ÿฌํ•œ ํšจ๋Šฅ์€ ์—ฐ๊ตฌ๋ฅผ ํ†ตํ•ด ํ™•์‹คํ•˜๊ฒŒ ์ž…์ฆ๋œ ๋ฐ” ์žˆ์Šต๋‹ˆ๋‹ค. 

9. ๋ฉด์—ญ๋ ฅ ํ–ฅ์ƒ

์—ฌ๋Ÿฌ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด ๋ฟŒ๋ฆฌ๋Š” ๋ฉด์—ญ๋ ฅ์„ ๊ฐ•ํ™”ํ•  ์ˆ˜๋„ ์žˆ์Šต๋‹ˆ๋‹ค. ๋งŽ์€ ๋™๋ฌผ ์—ฐ๊ตฌ์—์„œ ๋งˆ์นด ๋ฟŒ๋ฆฌ ์ถ”์ถœ๋ฌผ์€ ๋Œ€์‹์„ธํฌ ํ™œ๋™์„ ์ด‰์ง„ํ•˜๊ณ  CD4+ T์„ธํฌ ๋ฐ ์ „์ฒด ๋ฐฑํ˜ˆ๊ตฌ๋ฅผ ์ฆ๊ฐ€์‹œํ‚ค๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๋Œ€์‹์„ธํฌ, ํ˜ธ์ค‘๊ตฌ, T์„ธํฌ(๋ฆผํ”„๊ตฌ)๋ฅผ ํฌํ•จํ•˜๋Š” ๋ฐฑํ˜ˆ๊ตฌ๋Š” ๋ฐ•ํ…Œ๋ฆฌ์•„, ๋ฐ”์ด๋Ÿฌ์Šค, ๊ณฐํŒก์ด์™€ ๊ฐ™์€ ์™ธ๋ถ€ ์นจ์ž…์ž๋ฅผ ๋ง‰์•„๋‚ด๋Š” ์‹ ์ฒด์˜ ์ค‘์š”ํ•œ ๋ฐฉ์–ด ์ˆ˜๋‹จ์ž…๋‹ˆ๋‹ค. ์ŠคํŠธ๋ ˆ์Šค ์ˆ˜์ค€์„ ์ ์ ˆํžˆ ๊ด€๋ฆฌํ•˜๋Š” ๊ฒƒ๋„ ๊ฐ•๋ ฅํ•œ ๋ฉด์—ญ ๊ธฐ๋Šฅ์„ ์œ ์ง€ํ•˜๋Š” ๋ฐ ์ค‘์š”ํ•ฉ๋‹ˆ๋‹ค. 

๊ฒฐ๋ก 

์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋งˆ์นด๋Š” ์™„์ „ํžˆ ์•ˆ์ „ํ•˜๋ฉฐ ๋ถ€์ž‘์šฉ์ด ์—†์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ ํŽ˜๋ฃจ์˜ ์•ˆ๋ฐ์Šค ์‚ฌ๋žŒ๋“ค์ด ์ˆ˜์ฒœ ๋…„๊ฐ„ ๋งˆ์นด๋ฅผ ์‹ํ’ˆ๊ณผ ์•ฝ์žฌ๋กœ ์‚ฌ์šฉํ•ด ์™”๋‹ค๋Š” ์‚ฌ์‹ค์€ ๋งˆ์นด๊ฐ€ ์ธ์ฒด์— ๋ฌธ์ œ๋ฅผ ์ผ์œผํ‚ค์ง€ ์•Š์Œ์„ ๋ณด์—ฌ์ค๋‹ˆ๋‹ค. ํ•˜์ง€๋งŒ ๋‹ค๋ฅธ ๋ณด์ถฉ์ œ์™€ ๋งˆ์ฐฌ๊ฐ€์ง€๋กœ ๋งˆ์นด๋ฅผ ์„ญ์ทจํ•˜๋ ค ํ•œ๋‹ค๋ฉด ์˜์‚ฌ์™€ ๋จผ์ € ์ƒ๋‹ดํ•˜๋Š” ๊ฒƒ์ด ์ข‹์Šต๋‹ˆ๋‹ค. 

๋งˆ์นด๊ฐ€ ์ž„์‚ฐ๋ถ€๋‚˜ ์ˆ˜์œ ๋ชจ์—๊ฒŒ๋„ ์•ˆ์ „ํ•œ์ง€๋Š” ์•„์ง ์—ฐ๊ตฌ์—์„œ ๋ฐํ˜€์ง„ ๋ฐ” ์—†์Šต๋‹ˆ๋‹ค. 

์ฐธ๊ณ ๋ฌธํ—Œ:

  1. Gonzales GF, Gonzales C, Gonzales-Castaรฑeda C. Lepidium meyenii (Maca): a plant from the highlands of Peru--from tradition to science. Forsch Komplementmed. 2009 Dec;16(6):373-80.
  2. Beharry S, Heinrich M. Is the hype around the reproductive health claims of maca (Lepidium meyenii Walp.) justified? J Ethnopharmacol. 2018 Jan 30;211:126-170.
  3. da Silva Leitรฃo Peres N , Cabrera Parra Bortoluzzi L , Medeiros Marques LL , et. al . Medicinal effects of Peruvian maca (Lepidium meyenii): a review. Food Funct. 2020 Jan 29;11(1):83-92.
  4. Zheng BL, He K, Kim CH, Rogers L, Shao Y, et. al. Effect of a lipidic extract from lepidium meyenii on sexual behavior in mice and rats. Urology. 2000 Apr;55(4):598-602
  5. https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1439-0272.2002.00519.x
  6. Dording CM, Fisher L, Papakostas G, Farabaugh A, et. al. A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction. CNS Neurosci Ther. 2008 Fall;14(3):182-91.
  7. Dording CM, Schettler PJ, Dalton ED, et. al. A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women. Evid Based Complement Alternat Med.
  8. Levine H, Jรธrgensen N, Martino-Andrade A, Mendiola J, et. al. Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update. 2017 Nov 1;23(6):646-659.
  9. Gonzales GF, Cordova A, Gonzales C, Chung A, et. al. Lepidium meyenii (Maca) improved semen parameters in adult men. Asian J Androl. 2001 Dec;3(4):301-3.
  10. Melnikovova I, Fait T, Kolarova M, Fernandez EC, Milella L. Effect of Lepidium meyenii Walp. on Semen Parameters and Serum Hormone Levels in Healthy Adult Men: A Double-Blind, Randomized, Placebo-Controlled Pilot Study. Evid Based Complement Alternat Med.
  11. Alcalde AM, Rabasa J. Does Lepidium meyenii (Maca) improve seminal quality? Andrologia. 2020 Nov;52(10):e13755.
  12. Lee MS, Lee HW, You S, Ha KT. The use of maca (Lepidium meyenii) to improve semen quality: A systematic review. Maturitas. 2016 Oct;92:64-69.
  13. https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1439-0272.2002.00519.x
  14. Zhang Y, Zhou F, Ge F. Effects of combined extracts of Lepidium meyenii and Allium tuberosum Rottl. on erectile dysfunction. BMC Complement Altern Med. 2019; 19: 59.
  15. Shin BC, Lee MS, Yang EJ, Lim HS, Ernst E. Maca (L. meyenii) for improving sexual function: a systematic review. BMC Complement Altern Med.
  16. Brooks NA, Wilcox G, Walker KZ, et. al, Stojanovska L. Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause. 2008 Nov-Dec;15(6):1157-62.
  17. Stojanovska L, Law C, Lai B, Chung T, et. al. Maca reduces blood pressure and depression, in a pilot study in postmenopausal women. Climacteric. 2015 Feb;18(1):69-78.
  18. Ruying Tang, Linyuan Wang, Aimin Lib, Antianxiety and antidepressant effects of Maca (L. meyenii) ethanolic extract on chronic unpredictable mild stress of rats through hypothalamic-pituitary-adrenal axis(2019)SDRP Journal of Food Science & Technology 4(4)
  19. Meissner HO, Reich-Bilinska H, Mscisz A, Kedzia B. Therapeutic Effects of Pre-Gelatinized Maca (Lepidium Peruvianum Chacon) used as a Non-Hormonal Alternative to HRT in Perimenopausal Women - Clinical Pilot Study. Int J Biomed Sci. 2006 Jun;2(2):143-59.
  20. Meissner HO, Mscisz A, Reich-Bilinska H, et al. Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): Int J Biomed Sci. 2006 Dec;2(4):360-74.
  21. https://www.sciencedirect.com/science/article/pii/S2213453016300362
  22. https://pubmed.ncbi.nlm.nih.gov/12183495/
  23. Rubio J, Yucra S, Gasco M, Gonzales GF. Dose-response effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol. Toxicol Mech Methods. 2011 Oct;21(8):628-34.
  24. Guo SS, Gao XF, Gu YR, et. al. Preservation of Cognitive Function by Lepidium meyenii (Maca) Is Associated with Improvement of Mitochondrial Activity and Upregulation of Autophagy-Related Proteins in Middle-Aged Mouse Cortex. Evid Based Complement Alternat Med.
  25. https://pubmed.ncbi.nlm.nih.gov/31337204/
  26. Zhu H, Wang R, Hua H, Qian H, Du P. Deciphering the potential role of Maca compounds prescription influencing gut microbiota in the management of exercise-induced fatigue by integrative genomic analysis. Front Nutr. 2022 Oct 12;9:1004174.
  27. https://pubmed.ncbi.nlm.nih.gov/27979138/
  28. Zhu H, Liu C, Qian H. Pharmaceutical Potential of High-Altitude Plants for Fatigue-Related Disorders: A Review. Plants (Basel). 2022 Jul 31;11(15):2004. doi: 10.3390/plants11152004. PMID: 35956482; PMCID: PMC9370126.
  29. https://pubmed.ncbi.nlm.nih.gov/21771453/
  30. Saric S, Sivamani RK. โ€œPolyphenols and Sunburn.โ€ Int J Mol Sci. 2016 Sep 9;17(9):1521. doi: 10.3390/ijms17091521. PMID: 27618035; PMCID: PMC5037798.
  31. Zha Z, Wang SY, Chu W, et. al. Isolation, purification, structural characterization and immunostimulatory activity of water-soluble polysaccharides from Lepidium meyenii. Phytochemistry. 2018 Mar;147:184-193.