์žฅ๊ณผ ๋‡Œ๊ฐ€ ์„œ๋กœ ์†Œํ†ตํ•œ๋‹ค๋Š” '์žฅ-๋‡Œ ์—ฐ๊ฒฐ(Gut-brain connection)'์ด๋ผ๋Š” ๋ง์„ ๋“ค์–ด๋ณด์…จ์„ ๊ฒƒ์ž…๋‹ˆ๋‹ค. ์‹ค์ œ๋กœ ์žฅ-๋‡Œ ์—ฐ๊ฒฐ ์ด๋ก ์€ ์ง€๋‚œ ์ˆ˜์‹ญ ๋…„๊ฐ„ ์—ฌ๋Ÿฌ ์—ฐ๊ตฌ๋ฅผ ํ†ตํ•ด ํ™•์‹คํ•˜๊ฒŒ ์ž…์ฆ๋œ ๋ฐ” ์žˆ์Šต๋‹ˆ๋‹ค. ๊ทธ๋ ‡๋‹ค๋ฉด '์ •์‹ -ํ”ผ๋ถ€ ์—ฐ๊ฒฐ'์ด๋ผ๋Š” ๊ฐœ๋…์€ ์–ด๋–จ๊นŒ์š”? 

์ •์‹ ํ”ผ๋ถ€ํ•™(Psychodermatology)์ด ๊ฐ์ •๊ณผ ํ”ผ๋ถ€ ์‚ฌ์ด์˜ ๋ณต์žกํ•œ ์ƒํ˜ธ์ž‘์šฉ์„ ์„ค๋ช…ํ•˜๋Š” ์—ด์‡ ๊ฐ€ ๋  ์ˆ˜ ์žˆ์„๊นŒ์š”? ์ •์‹ ํ”ผ๋ถ€ํ•™์ด๋ž€ ๋ฌด์—‡์ด๋ฉฐ, ์–ด๋–ป๊ฒŒ ํ•˜๋ฉด ์ด ์ƒˆ๋กœ์šด ํ•™๋ฌธ์„ ํ†ตํ•ด ํ”ผ๋ถ€ ๊ฑด๊ฐ•์„ ํ˜์‹ ์ ์œผ๋กœ ๊ฐœ์„ ํ•  ์ˆ˜ ์žˆ์„๊นŒ์š”?

์ •์‹ ํ”ผ๋ถ€ํ•™์ด๋ž€?

์ •์‹ ํ”ผ๋ถ€ํ•™์€ ํ”ผ๋ถ€ํ•™๊ณผ ์ •์‹ ํ•™์„ ์—ฐ๊ฒฐํ•˜๋Š” ์ƒˆ๋กœ์šด ํ•™๋ฌธ ๋ถ„์•ผ์ž…๋‹ˆ๋‹ค. ์ •์‹ ํ”ผ๋ถ€ํ•™์€ ๋ฐฑ๋ฐ˜์ฆ, ์—ฌ๋“œ๋ฆ„, ์ฃผ์‚ฌ๋น„์™€ ๊ฐ™์€ ํ”ผ๋ถ€ ์งˆํ™˜์„ ์ดํ•ดํ•˜๊ณ  ์น˜๋ฃŒํ•˜๋Š” ํ”ผ๋ถ€ํ•™๊ณผ ์šฐ์šธ์ฆ, ๋ถˆ์•ˆ, ์ •์‹ ๋ถ„์—ด์ฆ ๊ฐ™์€ ์ •์‹ ์งˆํ™˜๊ณผ ์ •์‹ ์„ ์ดํ•ดํ•˜๋ ค๋Š” ์‹ฌ๋ฆฌํ•™ ๋ฐ ์ •์‹ ํ•™์„ ํ†ตํ•ฉํ•ฉ๋‹ˆ๋‹ค.

์ •์‹ ํ”ผ๋ถ€ํ•™์€ ์ƒˆ๋กœ์šด ์˜ํ•™ ๋ถ„์•ผ๋ผ๋Š” ๊ฒฌํ•ด๊ฐ€ ์žˆ์ง€๋งŒ, ์‚ฌ์‹ค์€ ๊ณ ๋Œ€ ๊ทธ๋ฆฌ์Šค์˜ ํžˆํฌํฌ๋ผํ…Œ์Šค ์‹œ๋Œ€์— ์ฒ˜์Œ์œผ๋กœ ์–ธ๊ธ‰๋œ ๋ฐ” ์žˆ์Šต๋‹ˆ๋‹ค. ํžˆํฌํฌ๋ผํ…Œ์Šค๋Š” ์ž์‹ ์˜ ์ €์„œ์—์„œ ์ŠคํŠธ๋ ˆ์Šค์™€ ํ”ผ๋ถ€ ์‚ฌ์ด์˜ ์ƒ๊ด€๊ด€๊ณ„๋ฅผ ์ธ์ •ํ–ˆ์Šต๋‹ˆ๋‹ค. ์‹ฌ์ง€์–ด ๊ทธ๋Š” ์‚ฌ๋žŒ๋“ค์ด ์ •์‹ ์  ์ŠคํŠธ๋ ˆ์Šค ๋•Œ๋ฌธ์— ๋จธ๋ฆฌ๋ฅผ ์ฅ์–ด๋œฏ์€ ์‚ฌ๋ก€๋„ ์–ธ๊ธ‰ํ–ˆ์Šต๋‹ˆ๋‹ค.

๊ทธ ํ›„ 1850๋…„๋Œ€์—๋Š” ์œŒ๋ฆฌ์—„ ์ œ์ž„์Šค ์—๋ผ๋จธ์Šค ์œŒ์Šจ(William James Eramus Wilson)์ด ํ”ผ๋ถ€์˜ ์งˆ๋ณ‘(Diseases of the Skin)์ด๋ผ๋Š” ์ €์„œ์—์„œ ์ •์‹ ํ”ผ๋ถ€ํ•™์„ ์‹ฌ์ธต์ ์œผ๋กœ ์†Œ๊ฐœํ–ˆ์Šต๋‹ˆ๋‹ค. ์œŒ์Šจ์€ 'ํ”ผ๋ถ€ ์‹ ๊ฒฝ์ฆ(Skin neurosis)'์— ๋Œ€ํ•ด ์„ค๋ช…ํ–ˆ์Šต๋‹ˆ๋‹ค. ์ „๋ฌธ์ ์œผ๋กœ ํ”ผ๋ถ€ ์‹ ๊ฒฝ์ฆ์€ ๊ธฐ์งˆ์  ์›์ธ์ด ์—†๋Š” ์ •์‹ ์žฅ์• ๋กœ ์ธํ•ด ํ”ผ๋ถ€๊ฐ€ ์˜ํ–ฅ์„ ๋ฐ›๋Š” ์งˆํ™˜์œผ๋กœ ์ •์˜๋ฉ๋‹ˆ๋‹ค.

์œŒ์Šจ์€ ์ฃผ๋ณ€ ํ”ผ๋ถ€๋ณด๋‹ค ์ƒ‰์ด ๋ฐ์•„์ง€๋Š” ํ”ผ๋ถ€ ๋ณ‘๋ณ€, ๋ชจ๋ฐœ์ด ๋น ์ ธ ํƒˆ๋ชจ ๋ถ€์œ„๊ฐ€ ๋ฐœ์ƒํ•˜๋Š” ํƒˆ๋ชจ์ฆ, ํ”ผ๋ถ€ ์•„๋ž˜์— ๊ธฐ์ƒ์ถฉ์ด ์žˆ๋‹ค๋Š” ๋ง์ƒ์œผ๋กœ ์ธํ•œ ๊ฐ€๋ ค์›€์ฆ ๊ฐ™์€ ํ”ผ๋ถ€ ์งˆํ™˜๊ณผ ์ •์‹ ์žฅ์• ๊ฐ€ ์„œ๋กœ ๊ด€๋ จ๋˜์–ด ์žˆ๋‹ค๊ณ  ์ฃผ์žฅํ–ˆ์Šต๋‹ˆ๋‹ค. ๊ทธ๋Š” ๋•€์„ ๊ณผ๋„ํ•˜๊ฒŒ ํ˜๋ฆฌ๋Š” ์งˆํ™˜์ธ ๋‹คํ•œ์ฆ์„ ๋ถˆ์•ˆ, ๋‘๋ ค์›€, ๊ณตํฌ์ฆ, ์šฐ์šธ์ฆ ๊ฐ™์€ ์ •์‹ ์žฅ์• ์™€ ์—ฐ๊ด€ ์ง“๊ธฐ๊นŒ์ง€ ํ–ˆ์Šต๋‹ˆ๋‹ค.

ํ˜„๋Œ€์— ๋“ค์–ด ์ •์‹ ํ”ผ๋ถ€ํ•™์€ ์ŠคํŠธ๋ ˆ์Šค์™€ ๊ฐ™์€ ์ •์„œ์žฅ์•  ๋ฐ ์ •์‹ ์žฅ์• ๊ฐ€ ์–ด๋–ป๊ฒŒ ๋ฉด์—ญ๊ณ„์™€ ํ”ผ๋ถ€์— ์˜ํ–ฅ์„ ๋ฏธ์น  ์ˆ˜ ์žˆ๋Š”์ง€ ์—ฐ๊ตฌํ•˜๋Š” ์ •์‹ ์‹ ๊ฒฝ๋ฉด์—ญํ•™์ด๋ผ๋Š” ๋˜ ๋‹ค๋ฅธ ์ƒˆ๋กœ์šด ํ•™๋ฌธ๊ณผ ์—ฐ๊ฒฐ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.

๋งŽ์€ ์—ฐ๊ตฌ์ž์™€ ์ž„์ƒ์˜๋Š” ์‹ฌ๋ฆฌํ”ผ๋ถ€ํ•™์  ์žฅ์• ๋ฅผ ์ •์‹ ์ƒ๋ฆฌํ•™์  ์žฅ์• , ์ผ์ฐจ ์ •์‹ ํ•™์  ์žฅ์• , ์ด์ฐจ ์ •์‹ ํ•™์  ์žฅ์• ์˜ ์„ธ ๊ฐ€์ง€ ๋ฒ”์ฃผ๋กœ ๋‚˜๋ˆ•๋‹ˆ๋‹ค.

์ •์‹ ์ƒ๋ฆฌํ•™์  ์žฅ์• ๋Š” ์ŠคํŠธ๋ ˆ์Šค ๊ฐ™์€ ๊ฐ์ •์  ์ƒํƒœ์— ๋ฐ˜์‘ํ•˜๋Š” ํ”ผ๋ถ€์žฅ์• ์ž…๋‹ˆ๋‹ค. ์Šต์ง„, ๊ฑด์„  ๋“ฑ์ด ์ด ๋ฒ”์ฃผ์˜ ํ”ผ๋ถ€ ์งˆํ™˜์— ํ•ด๋‹นํ•ฉ๋‹ˆ๋‹ค.

์ผ์ฐจ ์ •์‹ ํ•™์  ์žฅ์• ๋Š” ์žํ•ด์„ฑ ํ”ผ๋ถ€์žฅ์• ๋ฅผ ์œ ๋ฐœํ•˜๋Š” ๋งˆ์Œ์˜ ์งˆํ™˜์ž…๋‹ˆ๋‹ค. ์ด ๋ฒ”์ฃผ์—๋Š” ๋ฐœ๋ชจ๊ด‘(Trichotillomania) ๊ฐ™์€ ์งˆํ™˜์ด ํฌํ•จ๋ฉ๋‹ˆ๋‹ค. ๋ฐœ๋ชจ๊ด‘์€ ๊ทน์‹ฌํ•œ ์ŠคํŠธ๋ ˆ์Šค๋‚˜ ๋‹ค๋ฅธ ์ •์‹ ์žฅ์• ๋กœ ์ธํ•ด ๋‘ํ”ผ๋‚˜ ์†๋ˆˆ์น๊ณผ ๊ฐ™์€ ๋‹ค์–‘ํ•œ ์‹ ์ฒด ๋ถ€์œ„์—์„œ ์ฒด๋ชจ๋ฅผ ๋ฝ‘๋Š” ๊ฒƒ์ด ํŠน์ง•์ธ ์งˆํ™˜์ž…๋‹ˆ๋‹ค.

์ด์ฐจ ์ •์‹ ํ•™์  ์žฅ์• ์—๋Š” ์™ธ๋ชจ๋ฅผ ์†์ƒ์‹œ์ผœ ์‚ฌํšŒ ๊ณตํฌ์ฆ๊ณผ ์ž์กด๊ฐ ์ €ํ•˜๋ฅผ ์œ ๋ฐœํ•˜๋Š” ํ”ผ๋ถ€์žฅ์• ๊ฐ€ ํฌํ•จ๋ฉ๋‹ˆ๋‹ค.

์ •์‹ ํ•™์  ๋˜๋Š” ์‹ฌ๋ฆฌํ•™์  ์žฅ์• ๊ฐ€ ํ”ผ๋ถ€์— ์ง•ํ›„๋กœ ๋‚˜ํƒ€๋‚˜๋Š” ๊ฒฝ์šฐ๋‚˜ ํ”ผ๋ถ€ ์งˆํ™˜์ด ์ •์‹ ์  ๋˜๋Š” ์‹ฌ๋ฆฌ์  ๋ฌธ์ œ๋ฅผ ์ผ์œผํ‚ค๋Š” ํ˜„์ƒ์€ ์—ฐ๊ตฌ๋ฅผ ํ†ตํ•ด ๋ช…๋ฐฑํžˆ ์ž…์ฆ๋˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋Š” ์ •์‹ ๊ณผ ํ”ผ๋ถ€ ์‚ฌ์ด์— ๋ช…ํ™•ํ•œ ์—ฐ๊ด€์„ฑ์ด ์žˆ์Œ์„ ์‹œ์‚ฌํ•ฉ๋‹ˆ๋‹ค.

'์ •์‹ -ํ”ผ๋ถ€ ์—ฐ๊ฒฐ' ์ดํ•ดํ•˜๊ธฐ

์žฅ-๋‡Œ ์—ฐ๊ฒฐ์ด ๊ด‘๋ฒ”์œ„ํ•˜๊ฒŒ ์—ฐ๊ตฌ๋˜๊ณ  ์ตœ๊ทผ ๋ช‡ ๋…„ ๋™์•ˆ ๋งŽ์€ ์ฃผ๋ชฉ์„ ๋ฐ›์•˜์Œ์—๋„ ๋ถˆ๊ตฌํ•˜๊ณ  ์ •์‹ -ํ”ผ๋ถ€ ์—ฐ๊ฒฐ์€ ํฐ ๊ด€์‹ฌ์„ ๋Œ์ง€ ๋ชปํ–ˆ์Šต๋‹ˆ๋‹ค. ์‚ฌ์‹ค, ์‹ ์ฒด๊ฐ€ ์„œ๋กœ ์—ฐ๊ฒฐ๋˜์–ด ์žˆ๋‹ค๋Š” ๊ฐœ๋…์€ ์ด์ œ์„œ์•ผ ํ˜„๋Œ€ ์˜ํ•™์—์„œ ๋ฐ›์•„๋“ค์—ฌ์ง€๊ธฐ ์‹œ์ž‘ํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค.

์ด๋Ÿฌํ•œ ์ƒํ˜ธ ์—ฐ๊ฒฐ์„ฑ์€ ์‹ ์ฒด์˜ ์–ด๋–ค ๋ถ€๋ถ„๋„ ๋‹ค๋ฅธ ๋ถ€๋ถ„๊ณผ ๋ถ„๋ฆฌ๋˜์–ด ์ž‘์šฉํ•˜๊ฑฐ๋‚˜ ๋ฌธ์ œ๋ฅผ ๊ฒช์ง€ ์•Š๋Š”๋‹ค๋Š” ๊ฒƒ์„ ์˜๋ฏธํ•ฉ๋‹ˆ๋‹ค. ์‹ ์ฒด์˜ ํ•œ ๋ถ€๋ถ„์ด ๊ท ํ˜•์„ ์žƒ์œผ๋ฉด ๋‹ค๋ฅธ ๋ถ€์œ„์—๋„ ์˜ํ–ฅ์ด ์ƒ๊ธธ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ฆ‰, ๋ถˆ๊ท ํ˜•ํ•œ ์žฅ๋‚ด ๋ฏธ์ƒ๋ฌผ ์ƒํƒœ๊ณ„๋Š” ๋‡Œ ๊ฑด๊ฐ•์— ์˜ํ–ฅ์„ ๋ฏธ์น  ์ˆ˜ ์žˆ๊ณ  ๋ถˆ์•ˆ ๊ฐ™์€ ์ •์‹ ์žฅ์• ๋Š” ํ”ผ๋ถ€์˜ ์™„์ „์„ฑ ๋ฐ ๊ฑด๊ฐ•์„ ์ €ํ•ดํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.

์ •์‹ ๊ณผ ํ”ผ๋ถ€๊ฐ€ ์—ฐ๊ฒฐ๋˜์–ด ์žˆ๋Š” ์ด์œ ๋Š” ๋ฌด์—‡์ผ๊นŒ์š”? ์ •์‹ ํ”ผ๋ถ€ํ•™์€ ์ด ์งˆ๋ฌธ์— ๋Œ€ํ•œ ํ†ต์ฐฐ์„ ์ œ์‹œํ•ฉ๋‹ˆ๋‹ค.

์ •์‹ ํ”ผ๋ถ€ํ•™์—์„œ๋Š” ๋‡Œ๋ฅผ ํฌํ•จํ•˜๋Š” ์‹ ๊ฒฝ๊ณ„์™€ ํ”ผ๋ถ€์˜ ๊ธฐ์›์ด ๊ฐ™๋‹ค๋Š” ์ ์„ ์ธ์ •ํ•ฉ๋‹ˆ๋‹ค. ์ดˆ๊ธฐ ํƒœ์•„ ๋ฐœ๋‹ฌ ๊ณผ์ •์ธ ๋ฐฐ์•„ ๋‹จ๊ณ„์—์„œ ์™ธ๋ฐฐ์—ฝ์ด๋ผ๊ณ  ํ•˜๋Š” ๋ฐฐ์•„์˜ ์ธต์€ ์ดํ›„์— ์‹ ๊ฒฝ๊ณ„์™€ ํ”ผ๋ถ€๋ฅผ ํ˜•์„ฑํ•ฉ๋‹ˆ๋‹ค. ์‹ ๊ฒฝ๊ณ„์™€ ํ”ผ๋ถ€์˜ ๊ธฐ์›์— ์ด๋Ÿฌํ•œ ๊ณตํ†ต ๋ถ„๋ชจ๊ฐ€ ์žˆ๋‹ค๋Š” ์‚ฌ์‹ค์€ ์ •์‹ ๊ณผ ํ”ผ๋ถ€์˜ ์—ฐ๊ด€ ๊ด€๊ณ„๋ฅผ ์„ค๋ช…ํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋ฉ๋‹ˆ๋‹ค.

์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋ฉ”๋ฅด์ผˆ ์„ธํฌ(Merkel cell)๋ผ๋Š” ํŠน์ˆ˜ํ•œ ์œ ํ˜•์˜ ์„ธํฌ์—์„œ ์ •์‹ ๊ณผ ํ”ผ๋ถ€ ์‚ฌ์ด์˜ ์ƒ๋ฆฌํ•™์  ์—ฐ๊ฒฐ์ด ๋ฐœ์ƒํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋ฉ”๋ฅด์ผˆ ์„ธํฌ๋Š” ํ”ผ๋ถ€ ์™ธ์ธต, ์ฆ‰ ํ‘œํ”ผ ์•„๋ž˜์— ์œ„์น˜ํ•œ ํŠน์ˆ˜์„ธํฌ์ž…๋‹ˆ๋‹ค. ์ด‰๊ฐ์„ ๋‹ด๋‹นํ•˜๋Š” ์ด ์„ธํฌ๋Š” ์ด‰๊ฐ์„ ๋‡Œ๋กœ ์ „๋‹ฌํ•˜๋Š” ์‹ ๊ฒฝ๊ณผ ๊ธด๋ฐ€ํžˆ ์—ฐ๊ฒฐ๋˜์–ด ์žˆ์Šต๋‹ˆ๋‹ค.

๋˜ํ•œ ๋ฉ”๋ฅด์ผˆ ์„ธํฌ๋Š” ํ™”ํ•™์  ๋ฉ”์‹ ์ €๋กœ๋„ ๋ถˆ๋ฆฌ๋Š” ์‹ ๊ฒฝ์ „๋‹ฌ๋ฌผ์งˆ์„ ์ฒด๋‚ด๋กœ ๋ฐฉ์ถœํ•˜๋Š” ๋ฐ ๊ด€์—ฌํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์‹œํ—˜๊ด€ ๋‚ด ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ์—ผ์ฆ์„ฑ ํ”ผ๋ถ€ ์งˆํ™˜์ด ์žˆ์„ ๊ฒฝ์šฐ ํ”ผ๋ถ€์— ์žˆ๋Š” ๋ฉ”๋ฅด์ผˆ ์„ธํฌ์˜ ํฌ๊ธฐ๋Š” ์ฆ๊ฐ€ํ•ฉ๋‹ˆ๋‹ค.

์ด ์™ธ์—๋„ ์ •์‹ ํ”ผ๋ถ€ํ•™์—์„œ๋Š” ์ŠคํŠธ๋ ˆ์Šค๊ฐ€ ์‹ ์ฒด์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ์„ ์—ฐ๊ตฌํ•ด ์ •์‹ -ํ”ผ๋ถ€ ์—ฐ๊ฒฐ์— ๋Œ€ํ•œ ๋งŽ์€ ํ†ต์ฐฐ๋ ฅ์„ ์ œ๊ณตํ•ฉ๋‹ˆ๋‹ค. ํ•œ ์—ฐ๊ตฌ์—์„œ๋Š” ๊ธ‰์„ฑ ์ •์„œ์  ์ŠคํŠธ๋ ˆ์Šค๊ฐ€ ๋น„๋งŒ์„ธํฌ ํ™œ์„ฑํ™”์™€ ํƒˆ๊ณผ๋ฆฝํ™”๋ฅผ ์ด‰์ง„ํ•  ์ˆ˜ ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๋น„๋งŒ์„ธํฌ๋Š” ํžˆ์Šคํƒ€๋ฏผ(Histamine)์„ ๋‹ด๊ณ  ์žˆ๋Š” ๋ฐฑํ˜ˆ๊ตฌ์ž…๋‹ˆ๋‹ค. ๋น„๋งŒ์„ธํฌ๋Š” ํ™œ์„ฑํ™”๋˜๋ฉด ํžˆ์Šคํƒ€๋ฏผ ๊ณผ๋ฆฝ์„ ํ˜ˆ์•ก์œผ๋กœ ๋ฐฉ์ถœํ•˜๋Š” ๋ฐ, ํƒˆ๊ณผ๋ฆฝํ™”๋ผ๊ณ  ๋ถˆ๋ฆฌ๋Š” ์ด ๊ณผ์ •์€ ํ”ผ๋ถ€์˜ ๊ฐ€๋ ค์›€์ฆ๊ณผ ๋ถ€์ข…์„ ์•…ํ™”์‹œํ‚ต๋‹ˆ๋‹ค.

์ •์‹ -ํ”ผ๋ถ€ ์—ฐ๊ฒฐ์„ ์•„์ฃผ ๋ช…๋ฐฑํžˆ ์ž…์ฆํ•˜๋Š” ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๊ฐ€ ๊ณ„์† ๋‚˜์˜ค๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ํ”ผ๋ถ€ ์งˆํ™˜์— ๊ฑธ๋ฆฐ ์‚ฌ๋žŒ์€ ์ •์‹ ์งˆํ™˜์„ ๊ฒช๋Š” ๊ฒฝ์šฐ๊ฐ€ ์•„์ฃผ ํ”ํ•ฉ๋‹ˆ๋‹ค. ํ•œ ์—ฐ๊ตฌ์—์„œ๋Š” ์Šต์ง„์ด ์žˆ๋Š” ์–ด๋ฆฐ์ด๋Š” ๊ทธ๋ ‡์ง€ ์•Š์€ ์–ด๋ฆฐ์ด๋ณด๋‹ค ์ฃผ์˜๋ ฅ๊ฒฐํ• ๊ณผ์ž‰ํ–‰๋™์žฅ์• ๊ฐ€ ๋ฐœ์ƒํ•  ์œ„ํ—˜์ด ํ›จ์”ฌ ๋” ๋†’์€ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค.

๋‹ค๋ฅธ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋ฏผ๊ฐ์„ฑ ํ”ผ๋ถ€์ธ ์‚ฌ๋žŒ์€ ๋ถˆ์•ˆ์ฆ์ด ์ƒ๊ธฐ๊ฑฐ๋‚˜ ๋ถ‰์Œ์ฆ์ด ์•…ํ™”๋  ๊ฐ€๋Šฅ์„ฑ์ด ๋†’์Šต๋‹ˆ๋‹ค. ๋˜ ๋‹ค๋ฅธ ์—ฐ๊ตฌ์—์„œ๋Š” ์ฃผ์š” ์šฐ์šธ์žฅ์• ๋ฅผ ์•“๋Š” ์‚ฌ๋žŒ์˜ ๊ฒฝ์šฐ ๋ฐ˜์  ๊ฐ™์€ ํŒจํ„ด์œผ๋กœ ํ”ผ๋ถ€์ƒ‰์ด ํƒˆ์ƒ‰๋˜๋Š” ํ”ผ๋ถ€ ์งˆํ™˜์ธ ๋ฐฑ๋ฐ˜์ฆ์ด ๋ฐœ์ƒํ•  ์œ„ํ—˜์ด 64% ์ฆ๊ฐ€ํ•œ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ ๋ฐฑ๋ฐ˜์ฆ์€ ๋ถˆ์•ˆ์ฆ๊ณผ๋„ ์—ฐ๊ด€์„ฑ์ด ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋ฐฑ๋ฐ˜์ฆ์œผ๋กœ ์ง„๋‹จ๋ฐ›์€ ์‚ฌ๋žŒ์˜ ์•ฝ 36%๋Š” ๋ถˆ์•ˆ์ฆ๋„ ๊ฒช๊ณ  ์žˆ์—ˆ์Šต๋‹ˆ๋‹ค.

์‹ฌ๋ฆฌํ”ผ๋ถ€ํ•™์—์„œ๋Š” ์‹ฌ์ง€์–ด ์—ฌ๋“œ๋ฆ„๋„ ๊ฐ์ •์  ์ŠคํŠธ๋ ˆ์Šค์™€ ๊ด€๋ จ์ด ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ์ƒ๊ฐํ•ฉ๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ์ŠคํŠธ๋ ˆ์Šค๊ฐ€ ์ฆ๊ฐ€ํ•˜๋ฉด ์—ฌ๋“œ๋ฆ„์ด ์‹ฌํ•ด์ง‘๋‹ˆ๋‹ค. ์—ฌ์ž ์˜๋Œ€์ƒ์„ ๋Œ€์ƒ์œผ๋กœ ํ•œ ์—ฐ๊ตฌ์—์„œ๋Š” ์ŠคํŠธ๋ ˆ์Šค ์ธ์ง€๋„๊ฐ€ ๋†’์„์ˆ˜๋ก ์—ฌ๋“œ๋ฆ„์ด ๋” ์•…ํ™”๋˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค.

NAC, ๋น„ํƒ€๋ฏผB๊ตฐ, ์ŠคํŠธ๋ ˆ์Šค ์™„ํ™”

์—ฌ๋Ÿฌ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ํ”ผ๋ถ€ ์งˆํ™˜์„ ์น˜๋ฃŒํ•˜๊ณ  ์‹ถ์–ด ํ•˜๋Š” ์‚ฌ๋žŒ ์ค‘ ์ตœ๋Œ€ 40%๊ฐ€ ํ”ผ๋ถ€ ์งˆํ™˜์— ์˜ํ–ฅ์„ ๋ฏธ์น˜๊ฑฐ๋‚˜ ํ”ผ๋ถ€ ์งˆํ™˜์„ ์•…ํ™”์‹œํ‚ค๋Š” ๊ธฐ์ € ์ •์‹ ์žฅ์• ๋„ ์•“๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ์ด์œ  ๋•Œ๋ฌธ์— ์‹ฌ๋ฆฌํ”ผ๋ถ€ํ•™์—์„œ๋Š” ์ฆ์ƒ ์™„ํ™”๋ฅผ ์œ„ํ•ด ์ •์‹ ๊ณผ ํ”ผ๋ถ€๋ฅผ ํ•จ๊ป˜ ์น˜๋ฃŒํ•˜๋Š” ๋ฐ ์ง‘์ค‘ํ•ฉ๋‹ˆ๋‹ค. 

์‹ฌ๋ฆฌํ”ผ๋ถ€ํ•™ ๊ด€๋ จ ์—ฐ๊ตฌ๋Š” ์ •์‹  ๊ฑด๊ฐ• ๋ฐ ํ”ผ๋ถ€ ์งˆํ™˜์„ ๋ชจ๋‘ ๊ฐœ์„ ํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋˜๋Š” ๋‹ค์–‘ํ•œ ์น˜๋ฃŒ๋ฒ•์— ์ดˆ์ ์„ ๋งž์ถ”๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์ผ๋ถ€ ์—ฐ๊ตฌ์—์„œ๋Š” ์น˜๋ฃŒ๋ฒ•์˜ ์ผ๋ถ€๋กœ N-์•„์„ธํ‹ธ์‹œ์Šคํ…Œ์ธ(NAC, N-acetyl cysteine), ์ด๋…ธ์‹œํ†จ(Inositol), ์ŠคํŠธ๋ ˆ์Šค ์™„ํ™” ๊ธฐ๋ฒ•, ๋น„ํƒ€๋ฏผB12 ๋“ฑ์„ ์‚ฌ์šฉํ–ˆ์Šต๋‹ˆ๋‹ค.

์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด N-์•„์„ธํ‹ธ์‹œ์Šคํ…Œ์ธ์„ ์„ญ์ทจํ•˜๋ฉด ๊ฐ•๋ฐ•๊ฐ์— ๋ฐ˜๋ณต์ ์œผ๋กœ ํ”ผ๋ถ€๋ฅผ ๊ธ๊ฑฐ๋‚˜ ๋จธ๋ฆฌ์นด๋ฝ์„ ๋ฝ‘๋Š” ๊ฒƒ๊ณผ ๊ฐ™์€ ํ–‰๋™์„ ์–ต์ œํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋ฐœ๋ชจ๊ด‘ ํ™˜์ž 50๋ช…์ด ์ฐธ์—ฌํ•œ ์ด์ค‘๋งน๊ฒ€, ์œ„์•ฝ ๋Œ€์กฐ๊ตฐ ์—ฐ๊ตฌ์—์„œ N-์•„์„ธํ‹ธ์‹œ์Šคํ…Œ์ธ์€ ์œ„์•ฝ๊ณผ ๋น„๊ตํ–ˆ์„ ๋•Œ ๋จธ๋ฆฌ์นด๋ฝ์„ ๋ฝ‘๋Š” ์ฆ์ƒ์˜ ์ค‘์ฆ๋„๋ฅผ ํ˜„์ €ํžˆ ์™„ํ™”ํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค.

N-์•„์„ธํ‹ธ์‹œ์Šคํ…Œ์ธ(NAC)์€ ์•„๋ฏธ๋…ธ์‚ฐ์˜ ์ผ์ข…์ธ ์‹œ์Šคํ…Œ์ธ(Cysteine)์œผ๋กœ๋ถ€ํ„ฐ ํ•ฉ์„ฑ๋˜๋Š” ๋ฌผ์งˆ๋กœ, ๋จธ๋ฆฌ์นด๋ฝ๊ณผ ํ”ผ๋ถ€์— ๋ถ„ํฌํ•˜๋Š” ๋ฒ ํƒ€ ์ผ€๋ผํ‹ด(Beta-keratin) ๊ฐ™์€ ๋‹จ๋ฐฑ์งˆ์„ ๋งŒ๋“œ๋Š” ๋ฐ ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค. ํ•œ ์‚ฌ๋ก€์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋ฐœ๋ชจ๊ด‘์„ ๊ฒช๋Š” ์—ฌ์„ฑ์ด N-์•„์„ธํ‹ธ์‹œ์Šคํ…Œ์ธ์„ ๋ณด์ถฉํ–ˆ์„ ๋•Œ 3๊ฐœ์›” ์ด๋‚ด์— ๋จธ๋ฆฌ์นด๋ฝ์„ ์™„์ „ํžˆ ๋‹ค์‹œ ๊ธฐ๋ฅผ ์ˆ˜ ์žˆ์—ˆ์Šต๋‹ˆ๋‹ค.

์ž์‹ ์˜ ํ”ผ๋ถ€๋ฅผ ๊ณผ๋„ํ•˜๊ฒŒ ๋œฏ๋Š” ์งˆํ™˜์ธ ํ”ผ๋ถ€๋œฏ๊ธฐ์ฆ์— ๊ด€ํ•œ ์—ฐ๊ตฌ์—์„œ๋Š” ์ด๋…ธ์‹œํ†จ์ด ํ”ผ๋ถ€๋œฏ๊ธฐ์ฆ์˜ ์ค‘์ฆ๋„๋ฅผ ์™„ํ™”ํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ์ด๋…ธ์‹œํ†จ์€ ๋ชธ๊ณผ ๋‡Œ ์ „์ฒด์— ๊ฑธ์ณ ๋ถ„ํฌํ•˜๊ณ  ๊ธฐ๋ถ„๊ณผ ๋‡Œ ๊ธฐ๋Šฅ์„ ๋•๋Š” ๋‹น์˜ ์ผ์ข…์ž…๋‹ˆ๋‹ค.

๋˜ํ•œ ์—ฌ๋Ÿฌ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋ถˆ์•ˆ์„ ์ค„์ผ ๊ฒฝ์šฐ ํ”ผ๋ถ€ ๊ฑด๊ฐ•์„ ์ง์ ‘์ ์œผ๋กœ ๊ฐœ์„ ํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋ช…์ƒ ๋ฐ ๋งˆ์Œ์ฑ™๊น€์— ๊ธฐ๋ฐ˜ํ•œ ์ŠคํŠธ๋ ˆ์Šค ์™„ํ™”๋ฒ• ๊ฐ™์€ ์‹ฌ์‹  ์š”๋ฒ•์€ ์œ„์•ฝ๊ณผ ๋น„๊ตํ•ด ์Šต์ง„ ๋ฐ ๊ฑด์„ ์ด ์žˆ๋Š” ์„ฑ์ธ์˜ ๊ฐ€๋ ค์šด ๋Š๋‚Œ๊ณผ ๊ธ๊ณ  ์‹ถ์€ ์š•๊ตฌ๋ฅผ ์ผ์ • ์ˆ˜์ค€์œผ๋กœ ๊ฐœ์„ ํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.

๋˜ํ•œ ๋น„ํƒ€๋ฏผB12๋ฅผ ๋ณด์ถฉ์ œ ํ˜•ํƒœ๋กœ ๋ฐ”๋ฅด๊ฑฐ๋‚˜ ์„ญ์ทจํ•ด๋„ ์ •์‹ -ํ”ผ๋ถ€ ์—ฐ๊ฒฐ์„ ๊ฐœ์„ ํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๋ฌด์ž‘์œ„, ์ด์ค‘๋งน๊ฒ€, ์œ„์•ฝ๋Œ€์กฐ๊ตฐ ์ž„์ƒ์‹œํ—˜์—์„œ ์–ด๋ฆฐ์ด์˜ ์Šต์ง„ ๋ณ‘๋ณ€์— ๊ตญ์†Œ ๋น„ํƒ€๋ฏผB12๋ฅผ ์‚ฌ์šฉํ–ˆ์Šต๋‹ˆ๋‹ค. 4์ฃผ๊ฐ„ ์ถ”์  ์กฐ์‚ฌ ๊ฒฐ๊ณผ, ๊ตญ์†Œ ๋น„ํƒ€๋ฏผB12๊ฐ€ ์œ„์•ฝ๋ณด๋‹ค ์Šต์ง„์„ ๊ฐœ์„ ํ•˜๋Š” ๋ฐ ๋” ํšจ๊ณผ์ ์ธ ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค. ํ•œ ์‚ฌ๋ก€์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด B12 ๋ณด์ถฉ์ œ๋Š” ์ฆ์ƒ์˜ ์‹ฌ๊ฐ์„ฑ์œผ๋กœ ์ธํ•ด ์ƒ๋‹นํ•œ ์–‘์˜ ๊ตญ์†Œ ์Šคํ…Œ๋กœ์ด๋“œ๋ฅผ ์‚ฌ์šฉํ•˜๋Š” ์น˜๋ฃŒ๊ฐ€ ํ•„์š”ํ–ˆ๋˜ 18์„ธ ๋‚จ์„ฑ์˜ ์Šต์ง„์„ ๊ฐœ์„ ํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.

์—ฌ๋Ÿฌ ์—ฐ๊ตฌ์—์„œ ๋น„ํƒ€๋ฏผB๊ตฐ, ๊ทธ์ค‘์—์„œ๋„ ํŠนํžˆ ๋น„ํƒ€๋ฏผB6์™€ ๋น„ํƒ€๋ฏผB12๊ฐ€ ์ „๋ฐ˜์ ์ธ ๊ธฐ๋ถ„์„ ๊ฐœ์„ ํ•˜๊ณ  ์ŠคํŠธ๋ ˆ์Šค ์ธ์ง€๋„๋ฅผ ๋‚ฎ์ถœ ์ˆ˜ ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์ง„ ์‚ฌ์‹ค์€ ํฅ๋ฏธ๋กญ์Šต๋‹ˆ๋‹ค.

๊ฒฐ๋ก 

์ •์‹ ํ”ผ๋ถ€ํ•™์€ ์ •์‹ ๊ณผ ํ”ผ๋ถ€์˜ ์ƒํ˜ธ ์—ฐ๊ฒฐ์„ฑ์— ๊ทผ๊ฑฐํ•œ ์ƒˆ๋กœ์šด ํ•™๋ฌธ์ž…๋‹ˆ๋‹ค. ๋ฏธ๋ž˜์—๋Š” ์ •์‹ ํ”ผ๋ถ€ํ•™์  ๊ด€์ ์—์„œ ์ •์‹ -ํ”ผ๋ถ€ ์—ฐ๊ฒฐ์„ ๊ณ ๋ คํ•˜๋Š” ๊ฒƒ์ด ๊ฑด๊ฐ•ํ•˜๊ณ  ์–ด๋ ค ๋ณด์ด๋Š” ํ”ผ๋ถ€์™€ ๊ฑด์ „ํ•œ ๋งˆ์Œ์„ ๊ฐ€๊พธ๋Š” ์ข‹์€ ๋ฐฉ๋ฒ•์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ •์‹ ํ”ผ๋ถ€ํ•™์€ ์ŠคํŠธ๋ ˆ์Šค์— ๋Œ€ํ•œ ์‹ ์ฒด ๋ฐ˜์‘์˜ ์ดˆ๊ธฐ ์‹ ํ˜ธ๋กœ์„œ ์ •์‹  ๊ฑด๊ฐ• ์ƒํƒœ๊ฐ€ ํ”ผ๋ถ€์— ๋‚˜ํƒ€๋‚˜๋Š” ์ง•ํ›„์— ์ดˆ์ ์„ ๋งž์ถค์œผ๋กœ์จ ์ˆ˜๋ช…์„ ์—ฐ์žฅํ•˜๋Š” ๋ฐ๋„ ๊ธฐ์—ฌํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.

์ •์‹ ์ด ํ”ผ๋ถ€์—, ํ”ผ๋ถ€๊ฐ€ ์ •์‹ ์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ์„ ๋‹ค๋ฃจ๋Š” ์ •์‹ ํ”ผ๋ถ€ํ•™์  ์ ‘๊ทผ ๋ฐฉ์‹์ด ์ •์‹ ๊ณผ ํ”ผ๋ถ€๋ฅผ ์œ„ํ•œ ๋…ธํ™” ๋ฐฉ์ง€ ๋ฃจํ‹ด์˜ ์—ด์‡ ์ผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.

์ฐธ๊ณ ๋ฌธํ—Œ:

  1. Arck PC, Slominski A, Theoharides TC, et al. Neuroimmunology of stress: skin takes center stage. J Invest Dermatol. 2006;126:1697-1704
  2. Boulais N, Pereira U, Lebonvallet N, et al. Merkel cells as putative regulatory cells in skin disorders: an in vitro study. PLoS One. 2009;4(8):e6528. Published 2009 Aug 11. doi:10.1371/journal.pone.0006528
  3. Chesini Ms D, Caminati Md M. Vitamin B12 and atopic dermatitis: any therapeutic relevance for oral supplementation? J Diet Suppl. 2022;19(2):238-242. doi:10.1080/19390211.2020.1860180
  4. Franรงa K, Chacon A, Ledon J, Savas J, Nouri K. Pyschodermatology: a trip through history. An Bras Dermatol. 2013;88(5):842-843. doi:10.1590/abd1806-4841.20132059
  5. Gieler U, Gieler T, Peters EMJ, Linder D. Skin and psychosomatics โ€“ psychodermatology today. J Dtsch Dermatol Ges. 2020;18(11):1280-1298. doi:10.1111/ddg.14328
  6. Graubard R, Perez-Sanchez A, Katta R. Stress and skin: an overview of mind body therapies as a treatment strategy in dermatology. Dermatol Pract Concept. 2021;11(4):e2021091. Published 2021 Sep 1. doi:10.5826/dpc.1104a91
  7. Jafferany M. Psychodermatology: a guide to understanding common psychocutaneous disorders. Prim Care Companion J Clin Psychiatry. 2007;9(3):203-213. doi:10.4088/pcc.v09n0306
  8. Joviฤ‡ A, Marinoviฤ‡ B, Kostoviฤ‡ K, ฤŒeoviฤ‡ R, Basta-Juzbaลกiฤ‡ A, Bukviฤ‡ Mokos Z. The impact of pyschological stress on acne. Acta Dermatovenerol Croat. 2017;25(2):1133-1141.
  9. Koo J, Lebwohl A. Psycho dermatology: the mind and skin connection. Am Fam Physician. 2001;64(11):1873-1878.
  10. Kussainova A, Kassym L, Akhmetova A, et al. Vitiligo and anxiety: a systematic review and meta-analysis. PLoS One. 2020;15(11):e0241445. Published 2020 Nov 10. doi:10.1371/journal.pone.0241445
  11. Lochner C, Roos A, Stein DJ. Excoriation (skin-picking) disorder: a systematic review of treatment options. Neuropsychiatr Dis Treat. 2017;13:1867-1872. Published 2017 Jul 14. doi:10.2147/NDT.S121138
  12. Manav V, Karaali MG, Erdem O, Koku Aksu AE. Association between biophysical properties and anxiety in patients with sensitive skin. Skin Res Technol. 2022;28(4):556-563. doi:10.1111/srt.13156
  13. Nwankwo CO, Jafferany M. N-Acetylcysteine in psychodermatological disorders. Dermatol Ther. 2019;32(5):e13073. doi:10.1111/dth.13073
  14. Rodriguez-Cerdeira, C. Psychodermatology: past, present and future. Open Dermatol J. 2011;5(1):21-27. doi:10.2174/1874372201105010021
  15. Januchowski R. Evaluation of topical vitamin B(12) for the treatment of childhood eczema. J Altern Complement Med. 2009;15(4):387-389. doi:10.1089/acm.2008.0497
  16. Torales J, Barrios I, Villalba J. Alternative therapies for excoriation (skin picking) disorder: a brief update. Adv Mind Body Med. 2017;31(1):10-13.
  17. Vallerand IA, Lewinson RT, Parsons LM, et al. Vitiligo and major depressive disorder: a bidirectional population-based cohort study. J Am Acad Dermatol. 2019;80(5):1371-1379. doi:10.1016/j.jaad.2018.11.047
  18. Yaghmaie P, Koudelka CW, Simpson EL. Mental health comorbidity in patients with atopic dermatitis. J Allergy Clin Immunol. 2013;131(2):428-433. doi:10.1016/j.jaci.2012.10.041
  19. Young LM, Pipingas A, White DJ, Gauci S, Scholey A. A systematic review and meta-analysis of B vitamin supplementation on depressive symptoms, anxiety, and stress: effects on healthy and "at-risk" individuals. Nutrients. 2019;11(9):2232. Published 2019 Sep 16. doi:10.3390/nu11092232
  20. Zari S, Alrahmani D. The association between stress and acne among female medical students in Jeddah, Saudi Arabia. Clin Cosmet Investig Dermatol. 2017;10:503-506. Published 2017 Dec 5. doi:10.2147/CCID.S148499
  21. Zhu Z, Yang Z, Wang C, Liu H. Assessment of the effectiveness of vitamin supplement in treating eczema: a systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019;2019:6956034. Published 2019 Oct 31. doi:10.1155/2019/6956034