์ด ์„ธ์…˜์— ๋Œ€ํ•œ ๊ธฐ๋ณธ ์„ค์ •์ด ์—…๋ฐ์ดํŠธ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ๊ณ ๊ฐ๋‹˜์˜ ๊ณ„์ • ์„ค์ •์„ ์˜๊ตฌ์ ์œผ๋กœ ๋ณ€๊ฒฝํ•˜๋ ค๋ฉด ๋‚ด ๊ณ„์ •์œผ๋กœ ์ด๋™ํ•˜์„ธ์š”.
์›ํ•˜๋Š” ์ˆ˜๋ น ๊ตญ๊ฐ€ ๋˜๋Š” ์‚ฌ์šฉ ์–ธ์–ด๋ฅผ ๋‚ด ๊ณ„์ •์—์„œ ์–ธ์ œ๋“ ์ง€ ์—…๋ฐ์ดํŠธํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
> beauty2 heart-circle sports-fitness food-nutrition herbs-supplements pageview
클릭하여 iHerb 접근성 정책 보기
₩40,000 이상 주문 시 무료배송
iHerb 앱
checkoutarrow
KR

SAMe의 효능: 기분 개선, 통증 감소, 두뇌 활성화 효과

41,495 조회수

anchor-icon 목차 dropdown-icon
anchor-icon 목차 dropdown-icon

์‚ฌ๋žŒ์—๊ฒŒ SAMe(SAMe, SAM-e, S-์•„๋ฐ๋…ธ์‹ค๋ฉ”ํ‹ฐ์˜ค๋‹Œ, S-์•„๋ฐ๋…ธ์‹ค-L-๋ฉ”ํ‹ฐ์˜ค๋‹Œ, ์•„๋ฐ๋ฉ”ํ‹ฐ์˜ค๋‹Œ)๋Š” ๊ฐ€์žฅ ์ž์—ฐ์ ์ธ ํ•ญ์šฐ์šธ์ œ์ž…๋‹ˆ๋‹ค. ์ด๋Š” SAMe๊ฐ€ ์šฐ๋ฆฌ ๋ชธ ์ „์ฒด์˜ ์„ธํฌ ๋‚ด์—์„œ 100๊ฐ€์ง€ ์ด์ƒ์˜ ์ƒ๋ฌผํ•™์  ๊ฒฝ๋กœ์— ๊ด€์—ฌํ•˜๊ธฐ ๋•Œ๋ฌธ์ž…๋‹ˆ๋‹ค. SAMe๋Š” ๋ฉ”ํ‹ธ๊ธฐ(์ˆ˜์†Œ ์›์ž 3๊ฐœ๊ฐ€ ํƒ„์†Œ ์›์ž ํ•˜๋‚˜์— ๊ฒฐํ•ฉํ•œ ๊ฒƒ)์™€ ๋‹ค๋ฅธ ๋ถ„์ž๋ฅผ ๊ณต์—ฌํ•˜์—ฌ ์„ธํฌ๋ง‰, ํ•ญ์‚ฐํ™”๋ฌผ์งˆ, ๊ธฐ๋ถ„์„ ์กฐ์ ˆํ•˜๋Š” ์‹ ๊ฒฝ์ „๋‹ฌ๋ฌผ์งˆ, ๊ธฐํƒ€ ์ค‘์š”ํ•œ ์„ธํฌ ์„ฑ๋ถ„์— ํ•„์š”ํ•œ ๋‹จ๋ฐฑ์งˆ, ์ธ์ง€์งˆ์„ ํ˜•์„ฑํ•ฉ๋‹ˆ๋‹ค. SAMe๊ฐ€ DNA ์—ผ๊ธฐ์— ๊ณต์—ฌํ•˜๋Š” ๋ฉ”ํ‹ธ๊ธฐ๋Š” ์œ ์ „์ž ์ „์‚ฌ๋ฅผ "์ผœ๊ฑฐ๋‚˜", "๋Œ" ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋น„์ •์ƒ์ ์ธ ๋ฉ”ํ‹ธํ™”๋Š” ์šฐ์šธ์ฆ ๋ฐ ์น˜๋งค์™€ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๋‹ค(Bottiglieri, 2017). ์ด๋Ÿฌํ•œ ์ด์œ  ๋“ฑ์œผ๋กœ ์ ์ ˆํ•œ SAMe ์ˆ˜์ค€์„ ์œ ์ง€ํ•˜๋Š” ๊ฒƒ์ด ์ค‘์š”ํ•ฉ๋‹ˆ๋‹ค. SAMe๋Š” ์šฐ๋ฆฌ ๋ชธ์—์„œ ์ž์—ฐ์ ์œผ๋กœ ์ƒ์„ฑ๋˜์ง€๋งŒ, ์Œ์‹์ด๋‚˜ ๋ณด์กฐ์ œ๋ฅผ ํ†ตํ•ด SAMe๋ฅผ ์ถ”๊ฐ€๋กœ ์„ญ์ทจํ•ด์•ผ ํ•˜๋Š” ์‚ฌ๋žŒ๋“ค์ด ๋งŽ์€๋ฐ, ํŠนํžˆ ์šฐ์šธ์ฆ, ํŠน์ • ์‹ ์ฒด ์งˆ๋ณ‘์ด๋‚˜ ๊ณผ๋„ํ•œ ์ŠคํŠธ๋ ˆ์Šค๋ฅผ ๊ฒช๋Š” ๊ฒฝ์šฐ์— ๊ทธ๋ ‡์Šต๋‹ˆ๋‹ค. SAMe๋Š” ๋ชธ ์ „์ฒด์— ์กด์žฌํ•˜๋ฏ€๋กœ ๋‘๋‡Œ, ๊ฐ„, ๊ด€์ ˆ์„ ํฌํ•จํ•œ ๋‹ค์–‘ํ•œ ์žฅ๊ธฐ์™€ ์กฐ์ง์„ ์น˜์œ ํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.

๋ฏธ๊ตญ ์‹ํ’ˆ์˜์•ฝ์ฒญ(FDA) ์˜๋ฃŒ๊ด€๋ฆฌํ’ˆ์งˆ์กฐ์‚ฌ๊ตญ(AHRQ)์˜ SAMe ์ž„์ƒ์—ฐ๊ตฌ ๋ณด๊ณ ์„œ์—์„œ๋Š” SAMe๊ฐ€ ํ•ญ์šฐ์šธ์ œ๋งŒํผ ์šฐ์šธ์ฆ ์น˜๋ฃŒ์— ํšจ๊ณผ์ ์ด๋ผ๋Š” ๊ฒฐ๋ก ">๊ฒฐ๋ก ">๊ฒฐ๋ก ์„ ๋‚ด๋ ธ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ, AHRQ๋Š” SAMe๊ฐ€ ๊ณจ๊ด€์ ˆ์—ผ ๋ฐ ๊ฐ„ ์งˆํ™˜์— ๋„์›€์ด ๋œ๋‹ค๋Š” ์ ๋„ ๋ฐœ๊ฒฌ(2002)ํ–ˆ์œผ๋ฉฐ, ์ด๋ฅผ ํ™•์ธํ•  ์ถ”๊ฐ€ ์—ฐ๊ตฌ๊ฐ€ ํ•„์š”ํ•˜๋‹ค๋Š” ์ ๋„ ์–ธ๊ธ‰ํ–ˆ์Šต๋‹ˆ๋‹ค. ๊ฐ€๋ฒผ์šด ํ˜•ํƒœ์˜ ์šฐ์šธ์ฆ๋ณด๋‹ค๋Š” ์ค‘์ฆ ์ฃผ์š”์šฐ์šธ์žฅ์• (Major Depressive Disorders)์— ๊ฐ€์žฅ ํฐ ๋„์›€์ด ๋œ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. 

SAM-e๋Š” 40ํšŒ ์ด์ƒ์˜ ์ž„์ƒ ์—ฐ๊ตฌ๋ฅผ ํ†ตํ•ด ์ฃผ์š”์šฐ์šธ์žฅ์•  ์น˜๋ฃŒ์— ์•ˆ์ „ํ•˜๊ณ  ํšจ๊ณผ์ ์ธ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๋ฏธ๊ตญ ์‹ฌ๋ฆฌํ•™ํšŒ(American Psychiatric Association) ์—ฐ๊ตฌ ์œ„์›ํšŒ์˜ SAMe์— ๊ด€ํ•œ ์ตœ๊ทผ ๋ณด๊ณ ์„œ(Sharma ์™ธ, 2017)์—์„œ๋Š” SAMe๊ฐ€ ์ฒ˜๋ฐฉ ํ•ญ์šฐ์šธ์ œ์— ๋น„ํ•ด ๋ถ€์ž‘์šฉ์ด ํ›จ์”ฌ ์ ๊ณ  ๋‹ค๋ฅธ ์•ฝ๋ฌผ๊ณผ์˜ ์œ ํ•ดํ•œ ์ƒํ˜ธ์ž‘์šฉ์ด ์—†์Œ์„ ํ™•์ธํ–ˆ์Šต๋‹ˆ๋‹ค. ์‚ฌ์‹ค SAM-e๋Š” ๋‹ค๋ฅธ ์•ฝ๋ฌผ, ์•Œ์ฝ”์˜ฌ์˜ ๋…์„ฑ ํšจ๊ณผ์™€ ๊ฐ„์—ผ ๋“ฑ์˜ ๊ฐ์—ผ์ฆ์œผ๋กœ๋ถ€ํ„ฐ ๊ฐ„์„ ๋ณดํ˜ธํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ, ์—ฌ๋Ÿฌ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด SAM-e๋ฅผ ํ‘œ์ค€ ํ•ญ์šฐ์šธ์ œ(MAO ์–ต์ œ์ œ ํฌํ•จ)์™€ ๊ฒฐํ•ฉํ•˜๋ฉด ์น˜๋ฃŒ ๋ฐ˜์‘์„ ๊ฐœ์„ ํ•˜๊ณ  ์†๋„๋ฅผ ๋†’์ผ ์ˆ˜ ์žˆ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค(Alpert ์™ธ, 2004; Berlanga, ์™ธ, 1992; Torta ์™ธ, 1988). 

์šฐ์šธ์ฆ์— ๊ด€ํ•œ ์ตœ๊ทผ์˜ ๋‹ค๊ธฐ๊ด€ ๋ฌด์ž‘์œ„ ๋Œ€์กฐ ์—ฐ๊ตฌ์—์„œ๋Š” SAMe, ์—์Šค์‹œํƒˆ๋กœํ”„๋žŒ(escitalopram)๊ณผ ์œ„์•ฝ ๊ฐ„์˜ ์œ ์˜ํ•œ ์ฐจ์ด๋ฅผ ๋ฐœ๊ฒฌํ•˜์ง€ ๋ชปํ–ˆ๋Š”๋ฐ, ์ด๋Ÿฌํ•œ ๊ฒฐ๊ณผ๋Š” ์•„๋งˆ๋„ ์œ„์•ฝ ๋ฐ˜์‘๋ฅ ์ด ๊ฐ•ํ•˜๊ฒŒ ๋‚˜ํƒ€๋‚ฌ๊ฑฐ๋‚˜, ๋น„๊ต์  ๊ฐ€๋ฒผ์šด(์ค‘์ฆ์ด ์•„๋‹Œ) ์šฐ์šธ ์žฅ์• ๊ฐ€ ์žˆ๋Š” ์‚ฌ๋žŒ๋“ค์ด ์ฐธ์—ฌํ–ˆ๊ฑฐ๋‚˜, ํšจ๋Šฅ์ด ๋œํ•œ ํ˜•ํƒœ์˜ SAMe๋ฅผ ์‚ฌ์šฉํ–ˆ๊ธฐ ๋•Œ๋ฌธ์ผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋‘ ์ž„์ƒ ํ‰๊ฐ€ ์‚ฌ์ดํŠธ ์ค‘ ํ•˜๋‚˜์˜ ๋ฐ์ดํ„ฐ ์žฌ๋ถ„์„ ๊ฒฐ๊ณผ, SAMe๋ฅผ ์‚ฌ์šฉํ–ˆ์„ ๋•Œ ์šฐ์šธ์ฆ ๊ฐœ์„  ์ •๋„๋Š” ์—์Šค์‹œํƒˆ๋กœํ”„๋žŒ์„ ์‚ฌ์šฉํ–ˆ์„ ๋•Œ์™€ ๋™๋“ฑํ•œ ์ˆ˜์ค€์ด์—ˆ์œผ๋ฉฐ ๋‘˜ ๋‹ค ์œ„์•ฝ๋ณด๋‹ค ์œ ์˜ํ•˜๊ฒŒ ๋†’์€ ์ˆ˜์ค€์ž„์ด ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค(Sarris ์™ธ, 2014). ์—ฐ๊ตฌ ๊ฒฐ๊ณผ์— ์ฐจ์ด๊ฐ€ ์žˆ๋˜ ๊ฒƒ์€ ๋‘ ์‚ฌ์ดํŠธ์˜ ์—ฌ์„ฑ ๋Œ€ ๋‚จ์„ฑ ๋น„์œจ์ด ๋‹ฌ๋ž๊ฑฐ๋‚˜, ์—ฐ๊ตฌ ๋Œ€์ƒ์œผ๋กœ ์„ ์ •ํ•œ ํ™˜์ž์— ์ฐจ์ด๊ฐ€ ์žˆ์—ˆ๊ฑฐ๋‚˜, ๊ธฐํƒ€ ์š”์ธ ๋•Œ๋ฌธ์ผ ์ˆ˜๋„ ์žˆ์Šต๋‹ˆ๋‹ค. 

SAMe์˜ ์ข…๋ฅ˜

SAMe๊ฐ€ ๋ฏธ๊ตญ์— ์ฒ˜์Œ ์†Œ๊ฐœ๋˜์—ˆ์„ ๋•Œ, ์ตœ์ƒ ํ’ˆ์งˆ์˜ ์ œํ’ˆ์€ 1,4-butanedisulfonate(๋ถ€ํƒ„๋””์„คํฐ์‚ฐ์—ผ) SAMe๋ฅผ ์‚ฌ์šฉํ–ˆ์Šต๋‹ˆ๋‹ค. ํ•˜์ง€๋งŒ, ๊ฒฐ๊ตญ ๋Œ€๋‹ค์ˆ˜ ํšŒ์‚ฌ๊ฐ€ ์ €๋ ดํ•œ ํ†จ๋ฃจ์—๋„ค์ดํŠธ(toluenate) ๋˜๋Š” ํ† ์‹ค๋ ˆ์ดํŠธ(tosylate) ํ˜•ํƒœ๋กœ ์ „ํ™˜ํ–ˆ์Šต๋‹ˆ๋‹ค. ํ†จ๋ฃจ์—๋„ค์ดํŠธ ๋˜๋Š” ํ† ์‹ค๋ ˆ์ดํŠธ SAMe ์„ญ์ทจ๋กœ ์šฐ์šธ์ฆ์ด ๊ฐœ์„ ๋˜์ง€ ์•Š๋Š” ์‚ฌ๋žŒ์—๊ฒŒ๋Š” 1,4-butanedisulfonate SAMe๋ฅผ ์‹œํ—˜์ ์œผ๋กœ ํˆฌ์—ฌํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค. ์ž„์ƒ ์‹ค์Šต์—์„œ๋Š” 1,4-butanedisulfonate SAMe๊ฐ€ ์ธ์ง€ ๊ธฐ๋Šฅ์„ ๊ฐœ์„ ํ•˜๋Š” ํšจ๋Šฅ์ด ํŠนํžˆ ๋” ๊ฐ•๋ ฅํ•˜๊ณ (ํ•„์š” ์„ญ์ทจ๋Ÿ‰์ด ๋” ์ ์„ ์ˆ˜ ์žˆ์Œ) ๋” ํšจ๊ณผ์ ์ธ ๊ฒƒ์œผ๋กœ ๋ณด์ž…๋‹ˆ๋‹ค. 

์ตœ์ƒ ํ’ˆ์งˆ์˜ SAMe ์ œํ’ˆ์„ ์‚ฌ์šฉํ•˜๋Š” ๊ฒƒ์ด ํŠนํžˆ ์ค‘์š”ํ•ฉ๋‹ˆ๋‹ค. SAMe๋Š” ์‚ฐ์†Œ์™€ ๋น ๋ฅด๊ฒŒ ์ƒํ˜ธ์ž‘์šฉํ•˜๋ฏ€๋กœ, ์ •์ œ๋Š” ์šฉ๊ธฐ์— ๋‹ด๊ฒจ ํŒ๋งค๋˜๋Š” ๊ฒƒ์ด ์•„๋‹Œ ๊ฐœ๋ณ„ ๋ธ”๋ฆฌ์Šคํ„ฐ ํŒฉ์œผ๋กœ ํฌ์žฅ๋œ ๊ฒƒ์ด์–ด์•ผ ํ•ฉ๋‹ˆ๋‹ค. ์ด๋Ÿฐ ์‹์œผ๋กœ ๋ณดํ˜ธ๋˜์ง€ ์•Š๋Š” SAMe ์ •์ œ๋Š” ๋งค์žฅ ์ง„์—ด๋Œ€์— ์žˆ๋Š” ๋™์•ˆ์— ํšจ๋Šฅ์„ ์ƒ์‹คํ•˜๊ฒŒ ๋ฉ๋‹ˆ๋‹ค. ๊ฐ™์€ ์ด์œ ๋กœ, SAMe ์ •์ œ๋Š” ์‹œ๊ฐ„์ด ์ง€๋‚˜๋„ ํšจ๋Šฅ์„ ๋ณด์กดํ•˜๋„๋ก ๋งค์šฐ ์„ธ์‹ฌํ•˜๊ฒŒ ์ œ์กฐ๋˜์–ด์•ผ ํ•ฉ๋‹ˆ๋‹ค. 

SAMe์˜ ๋ถ€์ž‘์šฉ

SAMe๋Š” ์ž˜ ํก์ˆ˜๋  ์ˆ˜ ์žˆ๋„๋ก ๋ณดํ†ต ์•„์นจ ์‹์‚ฌ์™€ ์ ์‹ฌ ์‹์‚ฌ๋ฅผ ํ•˜๊ธฐ 30๋ถ„ ์ „์— ์„ญ์ทจํ•ฉ๋‹ˆ๋‹ค. ํ•˜์ง€๋งŒ ๊ฐ€๋ฒผ์šด ๋ฉ”์Šค๊บผ์›€์ด ๋ฐœ์ƒํ•  ์ˆ˜ ์žˆ์œผ๋ฉฐ, ์ด๋Ÿฐ ์ฆ์ƒ์€ ๋Œ€๊ฐœ SAM-e๋ฅผ ์„ญ์ทจํ•˜๊ธฐ ์ „์— ๊ฐ€๋ฒผ์šด ๊ฐ„์‹์„ ๋จน๊ฑฐ๋‚˜ ์ƒ๊ฐ• ์บก์Š์„ ์„ญ์ทจํ•˜์—ฌ ์™„ํ™”ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋ณตํ†ต, ์†Œํ™”๋ถˆ๋Ÿ‰, ์„ค์‚ฌ, ๋‘ํ†ต๋„ ๋ฐœ์ƒํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. SAMe๋Š” ํ™œ์„ฑํ™” ์ž‘์šฉ์„ ํ•˜๋ฏ€๋กœ, ๋ชจ๋“  ํ•ญ์šฐ์šธ์ œ์™€ ๋งˆ์ฐฌ๊ฐ€์ง€๋กœ ์ข…์ข… ๋ถˆ์•ˆ, ๊ณตํ™ฉ, ๋˜๋Š” ํฅ๋ถ„ ์ƒํƒœ๋ฅผ ์•…ํ™”์‹œํ‚ฌ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋‹ค๋ฅธ ํ•ญ์šฐ์šธ์ œ์™€ ๋งˆ์ฐฌ๊ฐ€์ง€๋กœ, SAMe๋Š” ์–‘๊ทน์„ฑ ์žฅ์• (์กฐ์šธ๋ณ‘)๊ฐ€ ์žˆ๋Š” ํ™˜์ž์˜ ๊ฒฝ์กฐ์ฆ ๋˜๋Š” ์กฐ์ฆ์„ ์ด‰๋ฐœํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋“œ๋ฌผ๊ฒŒ๋Š” ๋ถ€์ •๋งฅ์ด ์žˆ๋Š” ํ™˜์ž๊ฐ€ SAMe๋ฅผ ์„ญ์ทจํ•  ๊ฒฝ์šฐ, ์ฆ์ƒ์ด ์•…ํ™”๋  ์ˆ˜๋„ ์žˆ์Šต๋‹ˆ๋‹ค. ๋งŽ์€ ์ฒ˜๋ฐฉ ํ•ญ์šฐ์šธ์ œ์™€๋Š” ๋‹ฌ๋ฆฌ, SAMe๋Š” ์„ฑ์  ๋ถ€์ž‘์šฉ, ์ง„์ • ์ž‘์šฉ, ์ฒด์ค‘ ์ฆ๊ฐ€, ๋˜๋Š” ์ธ์ง€ ๊ธฐ๋Šฅ์˜ ๋ฐฉํ•ด๋ฅผ ์œ ๋ฐœํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค. SAMe๋Š” ๋…ธ์ธ๋“ค์—๊ฒŒ๋„ ํšจ๊ณผ๊ฐ€ ์ข‹์œผ๋ฉฐ ์ฒ˜๋ฐฉ ํ•ญ์šฐ์šธ์ œ๋ณด๋‹ค ๋‚ด์•ฝ์„ฑ์ด ์šฐ์ˆ˜ํ•ฉ๋‹ˆ๋‹ค.

SAMe์— ๊ด€ํ•œ ์˜คํ•ด

SAMe๋ฅผ ์˜จ๋ผ์ธ์œผ๋กœ ๊ฒ€์ƒ‰ํ•˜๋ฉด ๋งŽ์€ ์ •๋ณด๋ฅผ ์ฐพ์„ ์ˆ˜ ์žˆ๋Š”๋ฐ, ๊ทธ์ค‘ ์ผ๋ถ€๋Š” ์‚ฌ์‹ค์ด์ง€๋งŒ, ์ผ๋ถ€๋Š” ๊ทธ๋ ‡์ง€ ์•Š์Šต๋‹ˆ๋‹ค. ํ•œ ๊ฐ€์ง€ ๊ทผ๊ฑฐ ์—†๋Š” ๋ฏฟ์Œ์€ ๋น„๊ต ๋Œ€์กฐ๊ตฐ ์—†์ด SAMe ์šฉ์•ก์„ ์ฅ์˜ ๋‡Œ์— ์ง์ ‘ ์ฃผ์ž…ํ•œ ์—ฐ๊ตฌ์—์„œ ๋‚˜์˜จ ๊ฒƒ์ž…๋‹ˆ๋‹ค. ๋†€๋ž„ ๊ฒƒ๋„ ์—†์ด, ์ฃผ์ž…ํ•œ ์šฉ์•ก์€ ๋‡Œ๋ฅผ ์ž๊ทนํ•˜์—ฌ ๋–จ๋ฆผ์„ ์œ ๋ฐœํ–ˆ์Šต๋‹ˆ๋‹ค. ์ด๊ฒƒ์ด ์ž˜๋ชป ํ•ด์„๋˜์–ด SAMe๋ฅผ ๊ฒฝ๊ตฌ ์„ญ์ทจํ•˜๋ฉด ํŒŒํ‚จ์Šจ๋ณ‘์„ ์•…ํ™”์‹œํ‚ฌ ์ˆ˜ ์žˆ๋‹ค๋Š” ์„ค์ด ์ œ์‹œ๋œ ๊ฒƒ์ž…๋‹ˆ๋‹ค. ๋˜ํ•œ, SAMe๊ฐ€ L-๋„ํŒŒ(ํŒŒํ‚จ์Šจ๋ณ‘ ์น˜๋ฃŒ์•ฝ)์˜ ์น˜๋ฃŒ ํšจ๊ณผ๋ฅผ ๋ฐฉํ•ดํ•  ์ˆ˜๋„ ์žˆ๋‹ค๋Š” ์ž˜๋ชป๋œ ๊ฐœ๋…์ด ์ƒ๊ธฐ๊ฒŒ๋„ ํ–ˆ์Šต๋‹ˆ๋‹ค. ์‚ฌ์‹ค SAMe๋Š” ํŒŒํ‚จ์Šจ๋ณ‘์„ ์•“๊ณ  ์žˆ๋Š” ์‚ฌ๋žŒ์—๊ฒŒ ์•ˆ์ „ํ•  ๋ฟ๋งŒ ์•„๋‹ˆ๋ผ, ์œ ์ตํ•˜๊ธฐ๋„ ํ•ฉ๋‹ˆ๋‹ค(์•„๋ž˜ ์ฐธ์กฐ). ์ง€๊ธˆ๊นŒ์ง€ SAMe๊ฐ€ L-๋„ํŒŒ๋ฅผ ๋ฐฉํ•ดํ•œ๋‹ค๋Š” ์ฆ๊ฑฐ๋Š” ์—†์Šต๋‹ˆ๋‹ค. ์‹ค์ œ๋กœ๋Š” ๊ทธ ๋ฐ˜๋Œ€๋กœ ์ž‘์šฉํ•ฉ๋‹ˆ๋‹ค. L-๋„ํŒŒ๋ฅผ ๋งŒ์„ฑ์ ์œผ๋กœ ์‚ฌ์šฉํ•˜๋ฉด ์ €์žฅ๋œ SAMe๋ฅผ ๊ณ ๊ฐˆ์‹œํ‚ค๋ฏ€๋กœ, ๋ณด์กฐ์ œ๋ฅผ ํ†ตํ•ด SAMe๋ฅผ ๋ณด์ถฉํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค.

์ž์ฃผ ๋ฐ˜๋ณต๋˜๋Š” ๋˜ ํ•˜๋‚˜์˜ ๊ทผ๊ฑฐ ์—†๋Š” ๋ฏฟ์Œ์€ SAMe๊ฐ€ ํ˜ธ๋ชจ์‹œ์Šคํ…Œ์ธ(์‹ฌ์žฅ๋ณ‘์˜ ์œ„ํ—˜ ์ธ์ž)์˜ ์ˆ˜์ค€์„ ๋†’์ธ๋‹ค๋Š” ๊ฒƒ์ž…๋‹ˆ๋‹ค. ์‚ฌ์‹ค, ๋ฉ”์ด์š” ์˜๋ฃŒ์›(Mayo Clinic)์˜ ๋ฌด์ž‘์œ„ ๋Œ€์กฐ ์—ฐ๊ตฌ์—์„œ๋Š” SAMe๊ฐ€ ํ˜ˆ์žฅ ํ˜ธ๋ชจ์‹œ์Šคํ…Œ์ธ ๋†๋„๋ฅผ ๋ณ€ํ™”์‹œํ‚ค์ง€ ์•Š๋Š”๋‹ค๋Š” ์ ์„ ์ž…์ฆํ–ˆ์Šต๋‹ˆ๋‹ค(Thompson ์™ธ, 2009).

SAM-e ๊ถŒ์žฅ์„ญ์ทจ๋Ÿ‰

๋…ธ์ธ์ด๊ฑฐ๋‚˜, ํ˜„์ €ํ•œ ๋ถˆ์•ˆ์ฆ์ด ์žˆ๊ฑฐ๋‚˜, ์œ„์žฅ ๋ฌธ์ œ๊ฐ€ ์žˆ๊ฑฐ๋‚˜, ์‹ฌ๊ฐํ•œ ์งˆ๋ณ‘์ด ์žˆ๋Š” ๋ถ„์€ ํ•˜๋ฃจ 200 mg์˜ ์ ์€ ์–‘์œผ๋กœ SAM-e ์„ญ์ทจ๋ฅผ ์‹œ์ž‘ํ•ด์•ผ ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ƒ๋Œ€์ ์œผ๋กœ ๊ฑด๊ฐ•ํ•œ ๋ถ„์€ ํ•˜๋ฃจ 400 mg์œผ๋กœ ์‹œ์ž‘ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋ฌธ์ œ๊ฐ€ ๋ฐœ์ƒํ•˜์ง€ ์•Š๋Š”๋‹ค๋ฉด, 3~7์ผ ํ›„ ์„ญ์ทจ๋Ÿ‰์„ ๋งค์ฃผ 400 mg์—์„œ ์ตœ๋Œ€ 800mg์”ฉ ๋Š˜๋ ค๋„ ์ข‹์œผ๋ฉฐ, ์•„์นจ ์‹์‚ฌ์™€ ์ ์‹ฌ ์‹์‚ฌ ์ „์— ์„ญ์ทจํ•ฉ๋‹ˆ๋‹ค. ์ผ๋ฐ˜์ ์œผ๋กœ ๊ฐ€๋ฒผ์šด ์šฐ์šธ์ฆ์—๋Š” ํ•˜๋ฃจ 400~600 mg, ์ค‘๊ฐ„ ์ •๋„์˜ ์šฐ์šธ์ฆ์—๋Š” ํ•˜๋ฃจ 600~1200 mg, ์‹ฌํ•œ ์šฐ์šธ์ฆ์—๋Š” 1200~1600 mg, ๋งค์šฐ ์‹ฌํ•œ ์น˜๋ฃŒ-์ €ํ•ญ์„ฑ ์šฐ์šธ์ฆ์—๋Š” ํ•˜๋ฃจ 1600~2400 mg์„ ์„ญ์ทจํ•ฉ๋‹ˆ๋‹ค. ํ•˜๋ฃจ 1600 mg ์ด์ƒ์„ ์„ญ์ทจํ•˜๋ ค๋ฉด ๋จผ์ € ๋‹ด๋‹น ์˜์‚ฌ ๋ฐ SAMe ์ฒ˜๋ฐฉ ๊ฒฝํ—˜์ด ์žˆ๋Š” ์‚ฌ๋žŒ๊ณผ ์ƒ์˜ํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค.

SAMe์˜ ํšจ๊ณผ๋ฅผ ๊ทน๋Œ€ํ™”ํ•˜๋Š” ๋น„ํƒ€๋ฏผB ์„ญ์ทจ

SAM-e ๋ฉ”ํ‹ธํ™”(๋ฉ”ํ‹ธ๊ธฐ ๊ณต์—ฌ) ๊ฒฝ๋กœ์—๋Š” ๋ณด์กฐ์ธ์ž ๋น„ํƒ€๋ฏผB12(๋ฉ”ํ‹ธ์ฝ”๋ฐœ์•„๋ฏผ)์™€ ์—ฝ์‚ฐ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ๋น„ํƒ€๋ฏผ์ด ๊ฒฐํ•๋˜๋ฉด SAMe์˜ ํšจ๋Šฅ์ด ๊ฐ์†Œํ•  ์ˆ˜ ์žˆ์œผ๋ฏ€๋กœ, ํ•˜๋ฃจ 1,000 ug์˜ ๋น„ํƒ€๋ฏผB12, ํ•˜๋ฃจ 800~1,000 ug์˜ ์—ฝ์‚ฐ, ํ•˜๋ฃจ 50~100 mg์˜ ๋น„ํƒ€๋ฏผB6๋ฅผ ์„ญ์ทจํ•˜์—ฌ ๋ฐ”๋กœ์žก์„ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.  

๊ด€์ ˆ์—ผ, ์„ฌ์œ ๊ทผ์œกํ†ต ๊ฐœ์„ 

๊ด€์ ˆ์—ผ๊ณผ ์„ฌ์œ ๊ทผ์œกํ†ต์„ ์•“๋Š” ์‚ฌ๋žŒ๋“ค์€ ์ข…์ข… ์šฐ์šธํ•ด์ง‘๋‹ˆ๋‹ค. ๊ณจ๊ด€์ ˆ์—ผ(ํ•˜๋ฃจ 1200 mg์˜ SAMe) ๋ฐ ์„ฌ์œ ๊ทผ์œกํ†ต(ํ•˜๋ฃจ 800~1200 mg)์— ๊ด€ํ•œ ๋งŽ์€ ์—ฐ๊ตฌ์—์„œ๋Š” SAMe๊ฐ€ ํ†ต์ฆ๊ณผ ์—ผ์ฆ์„ ์™„ํ™”ํ–ˆ์Šต๋‹ˆ๋‹ค(Brown, Gerbarg, Muskin 2009). ๋…์ผ์˜ ๋ฌด์ž‘์œ„ ๋Œ€์กฐ ์‹œํ—˜(์ด 20,000๋ช… ์ด์ƒ์˜ ํ™˜์ž)์—์„œ๋Š” SAMe๊ฐ€ ๊ณจ๊ด€์ ˆ์—ผ ํ†ต์ฆ์„ ์ค„์ด๋Š” ๋ฐ ๋น„์Šคํ…Œ๋กœ์ด๋“œ์„ฑ ์†Œ์—ผ์ œ๋งŒํผ ํšจ๊ณผ์ ์ด๋ผ๋Š” ์ ์ด ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค(Bradley ์™ธ, 1994).

์šฐ์šธ์ฆ๊ณผ ๊ฐ„ ์งˆํ™˜

SAM-e๋Š” ์•Œ์ฝ”์˜ฌ, ์•ฝ๋ฌผ, ๋…์†Œ, ๊ฐ์—ผ, ๋˜๋Š” ๋‹ด์„์ฆ(์ž„์‹  ๊ธฐ๊ฐ„ ํฌํ•จ)์œผ๋กœ ์ธํ•œ ๊ฐ„๊ฒฝํ™” ๋˜๋Š” ๊ฐ„์—ผ ํ™˜์ž์˜ ๊ฐ„ ๊ธฐ๋Šฅ์„ ๊ฐœ์„ ํ•ฉ๋‹ˆ๋‹ค(Lieber 1999, 2005; Mato ์™ธ, 1999). ์ฒ˜๋ฐฉ ํ•ญ์šฐ์šธ์ œ(ํŠนํžˆ SSRI(์„ธ๋กœํ† ๋‹Œ ์žฌํก์ˆ˜ ์–ต์ œ์ œ))๋Š” ๊ฐ„ ๊ธฐ๋Šฅ ์žฅ์• ๋ฅผ ์œ ๋ฐœํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์Šคํƒ€ํ‹ด ๊ณ„์—ด ์•ฝ๋ฌผ(์ฝœ๋ ˆ์Šคํ…Œ๋กค์„ ๋‚ฎ์ถ”๋Š” ๋ฐ ์‚ฌ์šฉ)์„ ์ฒ˜๋ฐฉ ํ•ญ์šฐ์šธ์ œ์™€ ๊ฒฐํ•ฉํ•˜๋ฉด ๊ฐ„ ๊ธฐ๋Šฅ ์žฅ์•  ์œ„ํ—˜์ด ์ฆ๊ฐ€ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ํ•˜๋ฃจ 1200~1600 mg์˜ SAM-e์™€ ํด๋ฆฌ์—๋†€ํฌ์ŠคํŒŒํ‹ฐ๋”œ์ฝœ๋ฆฐ(polyenolphosphatidylcholine), ๊ทธ๋ฆฌ๊ณ  ํ•„์š” ์‹œ ๋ฒ ํƒ€์ธ(ํŠธ๋ฆฌ๋ฉ”ํ‹ธ๊ธ€๋ผ์ด์‹ ). ๋น„ํƒ€๋ฏผB๊ตฐ์•ŒํŒŒ๋ฆฌํฌ์‚ฐ์„ ํ•จ๊ป˜ ์„ญ์ทจํ•˜๋ฉด ๋ณดํ†ต ๋˜๋Š” ์‹ฌ๊ฐํ•˜๊ฒŒ ๋†’์€ ๊ฐ„ ๊ธฐ๋Šฅ ๊ฒ€์‚ฌ ์ˆ˜์น˜๋ฅผ ๋‚ฎ์ถœ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค(Lieber 2005; Efrati ์™ธ, 2003; Kharbanda et al. 2005). HIV/AIDS ํ™˜์ž์˜ ์šฐ์šธ์ฆ ์น˜๋ฃŒ์— ๋„์›€์ด ๋˜๋Š” ์ถ”๊ฐ€์ ์ธ ์ด์ ๋„ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค(Shippy ์™ธ, 2004).  

์šฐ์šธ์ฆ๊ณผ ํŒŒํ‚จ์Šจ๋ณ‘ ๊ฐœ์„ 

ํŒŒํ‚จ์Šจ๋ณ‘ ์น˜๋ฃŒ์— ์‚ฌ์šฉ๋˜๋Š” ์นด๋น„๋„ํŒŒ ๋“ฑ์˜ ํŠน์ • ์•ฝ๋ฌผ์€ ๋‘๋‡Œ์— ์ €์žฅ๋œ SAM-e๋ฅผ ๊ณ ๊ฐˆ์‹œ์ผœ ์น˜๋ฃŒ ์ €ํ•ญ์„ฑ ์šฐ์šธ์ฆ์„ ์œ ๋ฐœํ•ฉ๋‹ˆ๋‹ค(Carrieri, Indaco, Gentile, 1990). ์ด๋Ÿฌํ•œ ์šฐ์šธ์ฆ์€ SAMe์— ์ž˜ ๋ฐ˜์‘ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์˜ˆ๋น„ ์—ฐ๊ตฌ์—์„œ๋Š” ๋งค์šฐ ๋†’์€ ์šฉ๋Ÿ‰(ํ•˜๋ฃจ 1,600~4000 mg)์˜ SAM-e ์„ญ์ทจ๋กœ ํŒŒํ‚จ์Šจ๋ณ‘ ์ฆ์ƒ์ด ๊ฐœ์„ ๋  ์ˆ˜๋„ ์žˆ์Œ์„ ๋ณด์—ฌ์ฃผ์—ˆ์Šต๋‹ˆ๋‹ค(Di Rocco ์™ธ, 2000).  

์–ด๋ฆฐ์ด์˜ ์šฐ์šธ์ฆ

์–ด๋ฆฐ์ด๋ฅผ ๋Œ€์ƒ์œผ๋กœ ํ•œ SAM-e์˜ ์•ˆ์ „์„ฑ๊ณผ ํšจ๋Šฅ์— ๊ด€ํ•œ ๋Œ€์กฐ๊ตฐ ์—ฐ๊ตฌ ์‚ฌ๋ก€๋Š” ์—†์ง€๋งŒ, ๋ช‡๋ช‡ ์‚ฌ๋ก€ ๋ณด๊ณ ์—์„œ๋Š” ์–ด๋ฆฐ์ด์™€ ์ฒญ์†Œ๋…„ ์šฐ์šธ์ฆ ์น˜๋ฃŒ์— SAM-3๋ฅผ ์„ฑ๊ณต์ ์œผ๋กœ ์ด์šฉํ–ˆ์Œ์„ ๋ณด์—ฌ์ค๋‹ˆ๋‹ค(Schaller, Thomas, Bazzan, 2004).

์ฃผ์˜๋ ฅ ๊ฒฐํ• ์žฅ์•  ๊ฐœ์„ 

์ฃผ์˜๋ ฅ ๊ฒฐํ• ์žฅ์• ๋ฅผ ๊ด€๋ฆฌํ•˜๋Š” ๋ฐ ๊ฐ์„ฑ์ œ ์‚ฌ์šฉ์„ ์ตœ์†Œํ™”ํ•˜๋ ค๋Š” ๋ถ„๋“ค์€ SAMe๋ฅผ ๊ณ ๋ คํ•ด ๋ณผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ํ•œ ์†Œ๊ทœ๋ชจ ์—ฐ๊ตฌ์—์„œ๋Š” SAMe๋ฅผ ์‹œํ—˜์ ์œผ๋กœ ํˆฌ์—ฌํ•œ ๋‚จ์„ฑ๋“ค์˜ ์ฃผ์˜๋ ฅ ๊ฒฐํ• ์žฅ์•  ์ฆ์ƒ์ด ์œ ์˜ํ•˜๊ฒŒ ๊ฐœ์„ ๋œ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ํŠน์ • ํ—ˆ๋ธŒ(ํŠนํžˆ ๋กœ๋””์˜ฌ๋ผ ๋กœ์„ธ์•„)๋ฅผ ํ•จ๊ป˜ ์‚ฌ์šฉํ•˜๋ฉด ๊ทธ๋Ÿฌํ•œ ์ด์ ์„ ๋”์šฑ ๊ฐ•ํ™”ํ•  ์ˆ˜๋„ ์žˆ์Šต๋‹ˆ๋‹ค(Brown, Gerbarg, Muskin 2009).

์ธ์ง€ ๊ธฐ๋Šฅ, ๋…ธํ™”๋กœ ์ธํ•œ ์ธ์ง€๋ ฅ ๊ฐํ‡ด, ์น˜๋งค ๊ฐœ์„ 

๋ช‡๋ช‡ ์†Œ๊ทœ๋ชจ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด SAMe๊ฐ€ ๋‘๋‡Œ ๊ธฐ๋Šฅ์„ ๊ฐœ์„ ํ•  ์ˆ˜๋„ ์žˆ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค. ๋” ์ตœ๊ทผ์— ์‹œํ–‰๋œ ๋ฌด์ž‘์œ„ ๋Œ€์กฐ ์—ฐ๊ตฌ์—์„œ๋Š” SAMe, ๋น„ํƒ€๋ฏผ, ๊ฐ์ข… ์˜์–‘์†Œ๊ฐ€ ํฌํ•จ๋œ ์ œ์ œ๋ฅผ ํˆฌ์—ฌํ•œ ์ดˆ๊ธฐ, ์ค‘๊ธฐ ๋ฐ ๋” ์ง„ํ–‰๋œ ๋‹จ๊ณ„์˜ ์•Œ์ธ ํ•˜์ด๋จธ๋ณ‘ ํ™˜์ž์˜ ์ธ์ง€ ๋Šฅ๋ ฅ์ด ๊ฐœ์„ ๋˜์—ˆ์Œ์ด ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค(Chan ์™ธ, 2008; Remington ์™ธ, 2009; Remington ์™ธ, 2015).

๊ฒฐ๋ก 

์ƒ๋‹น์ˆ˜์˜ ์—ฐ๊ตฌ ๋‹จ์ฒด์—์„œ๋Š” ์šฐ์šธ์ฆ, ๊ณจ๊ด€์ ˆ์—ผ, ๊ฐ„ ์งˆํ™˜ ์น˜๋ฃŒ๋ฅผ ์œ„ํ•œ SAMe์˜ ์•ˆ์ „์„ฑ๊ณผ ํšจ๋Šฅ์„ ์ง€์ง€ํ•ฉ๋‹ˆ๋‹ค. ๋˜ํ•œ, ๋” ์ ์€ ์ˆ˜์˜ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ํŒŒํ‚จ์Šจ๋ณ‘, ์ฃผ์˜๋ ฅ ๊ฒฐํ• ์žฅ์• , ์‹ ๊ฒฝ ์ธ์ง€์  ์žฅ์• , ์•Œ์ธ ํ•˜์ด๋จธ๋ณ‘, HIV/AIDS, ์•ฝ๋ฌผ ๋‚จ์šฉ์„ ์น˜๋ฃŒํ•˜๋Š” ๋ฐ SAMe์— ์น˜๋ฃŒ์  ๊ฐ€์น˜๊ฐ€ ์žˆ์„ ์ˆ˜ ์žˆ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค.

์†Œ๋น„์ž๋“ค์€ ์ตœ์ƒ ํ’ˆ์งˆ์˜ SAMe๋ฅผ ์ฐพ๋Š” ๋ฐฉ๋ฒ•์— ๊ด€ํ•œ ์ •๋ณด๋ฅผ ํš๋“ํ•˜๋Š” ํ•œํŽธ, ์ธํ„ฐ๋„ท์— ์ž์ฃผ ๋“ฑ์žฅํ•˜๋Š” ์ž˜๋ชป๋œ ์ •๋ณด๋ฅผ ๊ฒฝ๊ณ„ํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค(Brown, Gerbarg, Muskin, 2009; Sharma ์™ธ, 2017).

 ์ฐธ๊ณ ๋ฌธํ—Œ: 

  1. Alpert, J. E., Papakostas, G., Mischoulon, D., et al. (2004). S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine. J Clin Psychopharmacol, 24(6), 661-4.
  2. Barak, A. J., Beckenhauer, H. C., & Tuma, D. J. (1996). Betaine, ethanol, and the liver: a review. Alcohol, 13(4), 395-8.
  3. Berger R, Nowak H. A new medical approach to the treatment of osteoarthritis: Report of an open phase IV study with ademetionine (gumbaral). Am J Med 1987; 83: 84-8.
  4. Berlanga, C., Ortega-Soto, H. A., Ontiveros, M., & Senties, H. (1992). Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine. Psychiatry Res, 44(3), 257-62.
  5. Bottiglieri T. In Complementary and Integrative Therapies for Psychiatric Disorders, Edited by Phillip R. Muskin, Patricia L. Gerbarg, and Richard P. Brown. Psychiatric Clinics of North America. March 2013, 36(1):121-140. doi: 10.1016/j.psc.2013.01.001.22. 
  6. Bottiglieri T, Gerbarg PL, Brown RP. S-Adenosylmethionine, Adometionine, SAMe. In Complementary and Integrative Treatments in Psychiatric Practice, edited by Gerbarg PL, Brown RP and Muskin PR. Washington D.C., American Psychiatric Association Publishing, 2017, pp 41-52.
  7. Bradley JD, Flusser D, Katz BP, et al. A randomized, double blind, placebo controlled trial of intravenous loading with s-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. The Journal of Rheumatology 1994; 21: 905-11.
  8. Brown RP and Gerbarg PL. Non-drug Treatments for ADHD: Options for Kids, Adults, and Clinicians. W.W. Norton & Company, New York, 2012.
  9. Brown RP, Gerbarg PL, Muskin PR. How to Use Herbs, Nutrients, and Yoga in Mental Health Care. W.W. Norton & Company, New York. 2009.
  10. Carrieri, P. B., Indaco, A., & Gentile, S. (1990). S-Adenosylmethionine treatment of depression in patients with Parkinson's disease: a double-blind crossover study versus placebo. Curr Ther Res, 48, 154-160.
  11. Chan A, Paskavitz J, Remington R, et al. Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer's disease: A 1-year, open-label pilot study with a 16-month caregiver extension. Am J Alzheimers Dis Other Demen 2008; 23: 571-85.
  12. Di Rocco A, Rogers JD, Brown R, et al. S-Adenosyl-Methionine improves depression in patients with parkinson's disease in an open-label clinical trial. Mov Disord 2000; 15: 1225-9.
  13. Efrati, O., Barak, A., Modan-Moses, D., et al. (2003). Liver cirrhosis and portal hypertension in cystic fibrosis. Eur J Gastroenterol Hepatol, 15(10), 1073-8.
  14. Kharbanda, K. K., Rogers, D. D. 2nd, Mailliard, M. E., et al.  (2005). A comparison of the effects of betaine and S-adenosylmethionine on ethanol-induced changes in methionine metabolism and steatosis in rat hepatocytes. J Nutr, 135(3), 519-24.
  15. Lieber, C. S. (1999). Role of S-adenosyl-L-methionine in the treatment of liver diseases. J Hepatol, 30(6), 1155-9.
  16. Lieber, C. S. (2005). Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years. Rocz Akad Med Bialymst, 50, 7-20.
  17. Mato, J. M., Camara, J., Fernandez de Paz, J., et al. (1999). S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol, 30(6), 1081-9.
  18. Mischoulon D, Price LH, Carpenter LL, et al. A double-blind, randomized, placebo-controlled clinical trial of s-adenosyl-l-methionine (SAMe) versus escitalopram in major depressive disorder. J Clin Psychiatry 2014; 75: 370-6.
  19. Remington R, Chan A, Paskavitz J, Shea TB. Efficacy of a vitamin/nutriceutical formulation for moderate-stage to later-stage Alzheimer's disease: A placebo-controlled pilot study. Am J Alzheimers Dis Other Demen 2009; 24: 27-33.
  20. Remington R, Bechtel C, Larsen D, et al. A phase II randomized clinical trial of a nutritional formulation for cognition and mood in Alzheimer's disease. J Alzheimers Dis 2015; 45: 395-405.
  21. Sarris J, Papakostas GI, Vitolo O, Fava M, Mischoulon D. S-adenosyl methionine (SAMe) versus escitalopram and placebo in major depression RCT: Efficacy and effects of histamine and carnitine as moderators of response. J Affect Disord 2014; 164: 76-81.
  22. Schaller, J. L., Thomas, J., & Bazzan, A. J. (2004). SAMe use in children and adolescents. Eur Child Adolesc Psychiatry, 13(5), 332-4.
  23. Sharma A, Gerbarg PL, Bottiglieri T, Massoumi L, Carpenter LL, Lavretsky H, Muskin PR, Brown RP, Mischoulon D. S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders:  A Clinician-Oriented Review of Research. J Clin Psych. 78(6):e656โ€“e667, 2017.
  24. US FDA Agency for Healthcare Research and Quality (AHRQ) reviewed, S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease (2002).
  25. Thompson MA, et al. 2009. Dietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy subjects: a double-blind, placebo-controlled, randomized clinical trial. JACM 15(5): 523-9
  26. Torta, R., Zanalda, F., Rocca, P. et al. (1988). Inhibitory activity of S-adenosyl-L-methionine on serum gamma-glutamyl-transpeptidase increase induced by psychodrugs and anticonvulsants.  Curr Ther Res, 44, 144-159.
  27. Varanese S, Birnbaum Z, Rossi R, Di Rocco A. Treatment of advanced Parkinson's disease. Parkinsons Dis 2011.

๋ฉด์ฑ…์‚ฌํ•ญ:์›ฐ๋‹ˆ์Šค ํ—ˆ๋ธŒ์˜ ์ทจ์ง€๋Š” ์˜ํ•™์ ์ธ ์ง„๋‹จ์ด๋‚˜ ์น˜๋ฃŒ๋ฅผ ์ œ๊ณตํ•˜๋Š” ๊ฒƒ์ด ์•„๋‹™๋‹ˆ๋‹ค. ์ž์„ธํžˆ ์•Œ์•„๋ณด๊ธฐ