์ด ์„ธ์…˜์— ๋Œ€ํ•œ ๊ธฐ๋ณธ ์„ค์ •์ด ์—…๋ฐ์ดํŠธ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ๊ณ ๊ฐ๋‹˜์˜ ๊ณ„์ • ์„ค์ •์„ ์˜๊ตฌ์ ์œผ๋กœ ๋ณ€๊ฒฝํ•˜๋ ค๋ฉด ๋‚ด ๊ณ„์ •์œผ๋กœ ์ด๋™ํ•˜์„ธ์š”.
์›ํ•˜๋Š” ์ˆ˜๋ น ๊ตญ๊ฐ€ ๋˜๋Š” ์‚ฌ์šฉ ์–ธ์–ด๋ฅผ ๋‚ด ๊ณ„์ •์—์„œ ์–ธ์ œ๋“ ์ง€ ์—…๋ฐ์ดํŠธํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
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์š”๋„ ๊ฐ์—ผ ๋˜๋Š” ์ผ๋ฐ˜์ ์œผ๋กœ UTI๋ผ๊ณ  ๋ถˆ๋ฆฌ๋Š” ์ด ์ฆ์ƒ์€ ๋‚จ์„ฑ๋ณด๋‹ค ์—ฌ์„ฑ์—๊ฒŒ ๋” ํ”ํ•˜๊ฒŒ ๋‚˜ํƒ€๋‚ฉ๋‹ˆ๋‹ค. ๋ฏธ๊ตญ์—์„œ๋Š” ์š”๋กœ ๊ฐ์—ผ์˜ ํ•ฉ๋ณ‘์ฆ์œผ๋กœ ๋งค๋…„ ์•ฝ 50๋งŒ ๋ช…์ด ์ž…์›ํ•ฉ๋‹ˆ๋‹ค. ๊ฐ€์žฅ ํ”ํ•œ ํ•ฉ๋ณ‘์ฆ์€ ํ˜ˆ์•ก์˜ ๋ฐ•ํ…Œ๋ฆฌ์•„ ๊ฐ์—ผ์ž…๋‹ˆ๋‹ค. ๋ฏธ๊ตญ์—์„œ๋Š” ์ง€๋‚œ 12๊ฐœ์›” ๋™์•ˆ ๊ฑฐ์˜ 11%์— ๋‹ฌํ•˜๋Š” ์—ฌ์„ฑ์ด ์š”๋กœ ๊ฐ์—ผ์„ ๊ฒช์—ˆ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ, 2 ๋ช…์˜ ์—ฌ์„ฑ ์ค‘ 1๋ช…์€ ํ‰์ƒ ์ ์–ด๋„ ํ•œ ๋ฒˆ์˜ ์š”๋กœ ๊ฐ์—ผ์„ ๊ฒช์„ ๊ฒƒ์œผ๋กœ ์ถ”์ •๋ฉ๋‹ˆ๋‹ค. ์ „ ์„ธ๊ณ„์ ์œผ๋กœ ๋งค๋…„ ์ˆ˜์ฒœ๋งŒ ๋ช…์˜ ์—ฌ์„ฑ์ด ์š”๋กœ ๊ฐ์—ผ์„ ์•“๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค.  

๊ฑฐ์˜ ๋งค์ผ, ์ ์–ด๋„ ํ•œ๋‘ ๋ช…์˜ ํ™˜์ž๊ฐ€ ์š”๋กœ ๊ฐ์—ผ๊ณผ ๊ด€๋ จ๋œ ์ฆ์ƒ์œผ๋กœ ์ €๋ฅผ ์ฐพ์•„์˜ต๋‹ˆ๋‹ค. ๊ทธ๋“ค์ด ํ˜ธ์†Œํ•˜๋Š” ์ฆ์ƒ์œผ๋กœ๋Š” ๋ฐฐ๋‡จ ์‹œ์˜ ๋”ฐ๋”๊ฑฐ๋ฆผ, ๋นˆ๋‡จ, ๊ธ‰ํ•จ, ํ—ˆ๋ฆฌ ํ†ต์ฆ, ๊ทธ๋ฆฌ๊ณ  ๋•Œ๋กœ๋Š” ์š”์‹ค๊ธˆ๋„ ์žˆ์Šต๋‹ˆ๋‹ค. 65 ์„ธ ์ด์ƒ์˜ ์‚ฌ๋žŒ๋“ค์—๊ฒŒ๋Š” ์š”๋กœ ๊ฐ์—ผ์ด ํ˜ผ๋ž€์„ ์ผ์œผํ‚ฌ ์ˆ˜ ์žˆ์œผ๋ฉฐ, ํŠนํžˆ ๋ฐ•ํ…Œ๋ฆฌ์•„๊ฐ€ ํ˜ˆ๋ฅ˜์— ๋“ค์–ด๊ฐ€๋ฉด ํ™˜๊ฐ๊นŒ์ง€๋„ ์ผ์œผํ‚ฌ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.  

๋ˆ„๊ฐ€ ๊ฐ์—ผ ์œ„ํ—˜์ด ์žˆ์Šต๋‹ˆ๊นŒ?  

์†Œ๋ณ€ ๊ฐ์—ผ์˜ ์œ„ํ—˜ ์š”์†Œ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค.  

  • ์—ฌ์„ฑ์ด ๋‚จ์„ฑ๋ณด๋‹ค ์œ„ํ—˜์— ๋” ๋…ธ์ถœ๋˜์–ด ์žˆ์Šต๋‹ˆ๋‹ค
  • 50์„ธ ์ด์ƒ์˜ ์—ฌ์„ฑ(ํ๊ฒฝ๊ธฐ)
  • ๋‹น๋‡จ๋ณ‘  
  • ๋‹น๋‡จ๋ณ‘ - ๋ฐ•ํ…Œ๋ฆฌ์•„๋Š” ์„คํƒ•์„ ๋จน์Šต๋‹ˆ๋‹ค. ์„ญ์ทจํ•˜๊ณ  ๋ฐฐ์„ค๋˜๋Š” ์„คํƒ•๋Ÿ‰์ด ๋งŽ์•„์งˆ์ˆ˜๋ก, ๋ฐ•ํ…Œ๋ฆฌ์•„๊ฐ€ ๋จน๊ณ  ์ž๋ผ๋Š” ์Œ์‹์ด ๋งŽ์•„์ง‘๋‹ˆ๋‹ค
  • ๋ฉด์—ญ ์–ต์ œ - ๊ฐ•ํ•œ ๋ฉด์—ญ ์ฒด๊ณ„๋Š” ๊ฐ์—ผ์„ ๋ง‰๋Š” ๋ฐ ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค
  • ์‹ ์žฅ ๊ฒฐ์„   
  • ์„ฑ๊ด€๊ณ„ - ๊ฐ์—ผ์ด ๋นˆ๋ฒˆํ•œ ์—ฌ์„ฑ์˜ ๊ฒฝ์šฐ, ๊ด€๊ณ„ ํ›„ ๋ฐฉ๊ด‘์„ ๋น„์šฐ๋ฉด ์˜ˆ๋ฐฉ์— ๋„์›€์ด ๋ฉ๋‹ˆ๋‹ค.  
  • ํŠน์ • ํ”ผ์ž„๋ฒ• - ํŠนํžˆ ํŽ˜์„œ๋ฆฌ๋Š” UTI์˜ ์›์ธ์ด ๋  ์ˆ˜๋„ ์žˆ์Šต๋‹ˆ๋‹ค.  
  • ์š”๋„ ์นดํ…Œํ„ฐ ์‚ฌ์šฉ
  • ๋น„๋‡จ๊ธฐ๊ด€ ๊ด€๋ จ ์น˜๋ฃŒ ๋˜๋Š” ์ˆ˜์ˆ 

์นผ์Š˜ ๋ณด์ถฉ์ œ๊ฐ€ ์š”๋กœ ๊ฐ์—ผ์˜ ์œ„ํ—˜์„ ์ฆ๊ฐ€์‹œํ‚ค๋‚˜์š”?  

Urological Research๋Š” ๊ณผ๋‹คํ•œ ์นผ์Š˜์„ ์„ญ์ทจํ•  ๊ฒฝ์šฐ ์š”๋กœ ๊ฐ์—ผ์˜ ์œ„ํ—˜์„ ์ฆ๊ฐ€ํ•  ์ˆ˜ ์žˆ๋‹ค๋Š” ์ฆ๊ฑฐ๋ฅผ ์ฐพ์•„๋ƒˆ์Šต๋‹ˆ๋‹ค. Alan Gaby ๋ฐ•์‚ฌ๋Š” Nutritional Medicine, 2๋ฒˆํ˜ธ์—์„œ ํ•˜๋ฃจ์— 1,500 mg ์ด์ƒ์˜ ์นผ์Š˜์„ ์„ญ์ทจํ•˜๋Š” ์‚ฌ๋žŒ์˜ ๊ฒฝ์šฐ, ๋ณต์š•๋Ÿ‰์„ 2-3ํšŒ์— ๊ฑธ์ณ ๋‚˜๋ˆ„์–ด์•ผ ํ•œ๋‹ค๊ณ  ๊ถŒ์žฅํ•ฉ๋‹ˆ๋‹ค. Gaby ๋ฐ•์‚ฌ๋Š” ๋งˆ๊ทธ๋„ค์Š˜์„ ์นผ์Š˜๊ณผ ํ•จ๊ป˜ ์„ญ์ทจํ•˜๋Š” ๊ฒƒ์ด ๋„์›€์ด ๋  ์ˆ˜ ์žˆ๋‹ค๊ณ  ๋งํ•ฉ๋‹ˆ๋‹ค. ๊ถŒ์žฅ ๋ณต์šฉ๋Ÿ‰ : ์นผ์Š˜ 500mg, 1์ผ 1ํšŒ ๋˜๋Š” 2ํšŒ

์š”๋กœ ๊ฐ์—ผ์„ ์ผ์œผํ‚ค๋Š” ๊ท 

์—์Šค์ผ€๋ฆฌ์น˜์•„๋Œ€์žฅ๊ท ์€ ์š”๋กœ ๊ฐ์—ผ ์›์ธ์˜ 80-90%๋ฅผ ์ฐจ์ง€ํ•ฉ๋‹ˆ๋‹ค. ๋Œ€๋ถ€๋ถ„์˜ ๋Œ€์žฅ๊ท  ๋ฐ•ํ…Œ๋ฆฌ์•„๋Š” ์žฅ๋‚ด์— ์žˆ์„ ๊ฒฝ์šฐ ์™„์ „ํžˆ ๋ฌดํ•ดํ•ฉ๋‹ˆ๋‹ค. ํ•˜์ง€๋งŒ ๋ฐ•ํ…Œ๋ฆฌ์•„๊ฐ€ ์š”๋„๋กœ ๋“ค์–ด๊ฐˆ ๊ฒฝ์šฐ, ์š”๋กœ ๊ฐ์—ผ์„ ์ดˆ๋ž˜ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.  

๋น„๋‡จ๊ธฐ ๊ฐ์—ผ์„ ์ผ์œผํ‚ค๋Š” ๋‹ค๋ฅธ ์„ธ๊ท ์œผ๋กœ๋Š” Klebsiella, Enterobacter, Enterococcus, Proteus, Pseudomonas, Staphylococcus, Streptococcus, Serratia ๋ฐ Candida-a ํšจ๋ชจ๊ฐ€ ์žˆ์Šต๋‹ˆ๋‹ค.  

๊ธ‰์„ฑ ๊ฐ์—ผ ์น˜๋ฃŒ์— ์‚ฌ์šฉ๋˜๋Š” ์ผ๋ฐ˜์ ์ธ ์•ฝ๋ฌผ

  • ์„ธํŒ”๋กœ์Šคํฌ๋ฆฐ – Cephalexin(์„ธํŒ”๋ ˆํ‚ค์‹ )
  • ํŠธ๋ฆฌ๋ฉ”์†Œํ”„๋ฆผ -์ˆ ํŒŒ๋ฉ”ํ†ก์‚ฌ์กธ
  • ๋‹ˆํŠธ๋กœํ‘ธ๋ž€ํ† ์ธ
  • ํ€ด๋†€๋ก ๊ณ„ ํ•ญ๊ท ์ œ

๊ฐ์—ผ ์˜ˆ๋ฐฉ์— ๋„์›€์„ ์ฃผ๋Š” 6๊ฐ€์ง€ ๋ฐฉ๋ฒ•

  1. ๋ฉด ์žฌ์งˆ์˜ ์†์˜ท ์ฐฉ์šฉ
  2. ๋งค์ผ ์ถฉ๋ถ„ํ•œ ์ˆ˜๋ถ„ ์„ญ์ทจ
  3. ๋งค์ผ ํฌ๋žœ๋ฒ ๋ฆฌ ์ฃผ์Šค๋ฅผ ์„ญ์ทจํ•˜๋ฉด UTI์˜ ๋นˆ๋„๋ฅผ ์ค„์ผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค
  4. ์†Œ๋ณ€์„ ์˜ค๋žซ๋™์•ˆ ์ฐธ์ง€ ๋งˆ์‹ญ์‹œ์˜ค
  5. ์†Œ๋ณ€์„ ๋‹ฆ์„ ๋•Œ, ํ•ญ๋ฌธ ๋ถ€์œ„์˜ ์„ธ๊ท ์ด ์š”๋„์™€ ์ ‘์ด‰ํ•˜๋Š” ๊ฒƒ์„ ๋ฐฉ์ง€ํ•˜๊ธฐ ์œ„ํ•ด ์•ž์—์„œ ๋’ค์ชฝ์œผ๋กœ ๋‹ฆ์Šต๋‹ˆ๋‹ค
  6. ์—ฌ์„ฑ์˜ ๊ฒฝ์šฐ ์œ„ํ—˜์„ ์ค„์ด๊ธฐ ์œ„ํ•ด ์„ฑ๊ด€๊ณ„ ํ›„ ์†Œ๋ณ€์„ ๋ณด๋„๋ก ํ•ฉ๋‹ˆ๋‹ค

์˜ˆ๋ฐฉ์„ ์œ„ํ•œ ์ฒ˜๋ฐฉ ์˜์•ฝํ’ˆ

  • Methenamine hippurate - 1996๋…„ ์—ฐ๊ตฌ์—์„œ๋Š”  methenamine์ด ๊ฐ์—ผ ์˜ˆ๋ฐฉ์— ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Œ์„ ๋ณด์—ฌ์ฃผ์—ˆ์Šต๋‹ˆ๋‹ค. 2014 ๋…„ ์—ฐ๊ตฌ์—์„œ๋„ ๋น„์Šทํ•œ ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค.  
  • ์„ฑ๊ด€๊ณ„ ํ›„ UTI ์œ„ํ—˜์— ์ฒ˜ํ•œ ์ผ๋ถ€ ์—ฌ์„ฑ์€ ํ•ญ์ƒ์ œ๋ฅผ 1ํšŒ ๋ถ„๋Ÿ‰ ๋ณต์šฉํ•˜๋Š”๋ฐ, ์ด๋Š” ๊ธ‰์„ฑ ์š”๋กœ ๊ฐ์—ผ ์˜ˆ๋ฐฉ์— ํ•ญ์ƒ์ œ๋ฅผ ๋งค์ผ ๋ณต์šฉํ•˜๋Š” ๊ฒƒ๊ณผ ๋งˆ์ฐฌ๊ฐ€์ง€์˜ ํšจ๊ณผ๋ฅผ ๋ณด์ž…๋‹ˆ๋‹ค.  
  • ํ˜ธ๋ฅด๋ชฌ ๋Œ€์ฒด์ œ - ๊ฒฝ๊ตฌ ์—์ŠคํŠธ๋กœ๊ฒ ๋Œ€์ฒด์ œ, ๋˜๋Š” ์งˆ ์—์ŠคํŠธ๋กœ๊ฒ ์ ์šฉ์€ ํ๊ฒฝ๊ธฐ ์—ฌ์„ฑ์—๊ฒŒ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋‹น์‹ ์˜ ๊ฑด๊ฐ• ๊ด€๋ฆฌ ์ƒ๋‹ด์‚ฌ์™€ ์œ„ํ—˜ ๋ฐ ์žฅ์ ์— ๋Œ€ํ•ด ์˜๋…ผํ•˜์‹ญ์‹œ์˜ค.  

์˜ˆ๋ฐฉ์— ๋„์›€์„ ์ฃผ๋Š” 1์ฐจ ๋ณด์ถฉ์ œ

์š”๋กœ ๊ฐ์—ผ์„ ์˜ˆ๋ฐฉํ•˜๋Š” ๋ฐ ๊ฐ€์žฅ ๋ณดํŽธ์ ์œผ๋กœ ์‚ฌ์šฉ๋˜๋Š” ๋ณด์ถฉ์ œ๋กœ๋Š” ํฌ๋žœ๋ฒ ๋ฆฌ,  D- ๋งŒ๋…ธ์˜ค์Šค, ๋ฐ ๋น„ํƒ€๋ฏผ C๊ฐ€ ์žˆ์Šต๋‹ˆ๋‹ค. ์ด๋กœ ์ถฉ๋ถ„ํ•˜์ง€ ์•Š์€ ๊ฒฝ์šฐ, ๋งŽ์€ ์‚ฌ๋žŒ๋“ค์ด ์•„๋ž˜์— ์„ค๋ช…๋œ ๋ณด์กฐ ๋ณด์ถฉ์ œ ์ค‘ ์ผ๋ถ€๋ฅผ ์ถ”๊ฐ€ ๋ณต์šฉํ•ฉ๋‹ˆ๋‹ค.  

ํฌ๋žœ๋ฒ ๋ฆฌ

ํฌ๋žœ๋ฒ ๋ฆฌ ๋ณด์ถฉ์ œ๋Š” ์š”๋กœ ๊ฐ์—ผ์˜ ์˜ˆ๋ฐฉ๋ฟ ์•„๋‹ˆ๋ผ ๋น„์šฉ์ ์ธ ๋ฉด์—์„œ๋„ ํšจ์œจ์ ์ธ ์„ ํƒ์‚ฌํ•ญ์ด๋ผ๊ณ  2014๋…„ Clinical Infectious Disease์˜ ์—ฐ๊ตฌ์—์„œ ๋ฐํ˜”์Šต๋‹ˆ๋‹ค. 2013๋…„ Nutrition Research์˜ ํ•œ ์—ฐ๊ตฌ์—์„œ๋Š” ์š”๋กœ ๊ฐ์—ผ ์žฌ๋ฐœ์˜ ์œ„ํ—˜์— ์ฒ˜ํ•œ ์‚ฌ๋žŒ๋“ค์—๊ฒŒ ํฌ๋žœ๋ฒ ๋ฆฌ ๋ณด์ถฉ์ œ๊ฐ€ ํšจ๊ณผ๋ฅผ ๋‚˜ํƒ€๋ƒˆ์Šต๋‹ˆ๋‹ค. 2014๋…„ Journal of the American Geriatric Society์˜ ํ•œ ์—ฐ๊ตฌ์—์„œ๋Š” ์–‘๋กœ์›๊ณผ ๊ฐ™์€ ์žฅ๊ธฐ ์š”์–‘ ์‹œ์„ค์— ๊ฑฐ์ฃผํ•˜๋Š” ๊ณ ์œ„ํ—˜์˜ ๋…ธ๋…„์ธต์„ ๋Œ€์ƒ์œผ๋กœ ์กฐ์‚ฌํ•œ ๊ฒฐ๊ณผ, ํฌ๋žœ๋ฒ ๋ฆฌ ๋ณด์ถฉ์ œ๋ฅผ ์„ญ์ทจํ•˜๊ณ  ๋‚˜์„œ ์š”๋กœ ๊ฐ์—ผ ์œ„ํ—˜์„ฑ์ด 26% ๊ฐ์†Œํ–ˆ์Šต๋‹ˆ๋‹ค. ํฌ๋žœ๋ฒ ๋ฆฌ ๊ณผ์ผ ์•ˆ์— ์žˆ๋Š” ๋ถ„์ž๋“ค์€ ํŠนํžˆ ๋Œ€์žฅ๊ท  ๋ฐ•ํ…Œ๋ฆฌ์•„๊ฐ€ ๋ฐฉ๊ด‘๋ฒฝ์— ๋‹ฌ๋ผ๋ถ™์ง€ ์•Š๋„๋ก ๋•์Šต๋‹ˆ๋‹ค. ๊ถŒ์žฅ ๋ณต์šฉ๋Ÿ‰ : ๋ ˆ์ด๋ธ”์˜ ์ง€์‹œ๋Œ€๋กœ ๋ณต์šฉํ•˜์‹ญ์‹œ์˜ค.  

D- ๋งŒ๋…ธ์˜ค์Šค

2014 ๋…„ ์—ฐ๊ตฌ์—์„œ๋Š” D- ๋งŒ๋…ธ์˜ค์Šค, ํฌ๋žœ๋ฒ ๋ฆฌ ๊ทธ๋ฆฌ๊ณ  ํ”„๋กœ๋ฐ”์ด์˜คํ‹ฑ ๋ฝํ†  ๋ฐ”์‹ค๋Ÿฌ์Šค์˜ ์กฐํ•ฉ์ด ์š”๋กœ ๊ฐ์—ผ์„ ์˜ˆ๋ฐฉํ•˜๋Š” ๋ฐ ํšจ๊ณผ๊ฐ€ ์žˆ๋‹ค๊ณ  ๋ฐํžˆ๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. 2017๋…„ ํ•™์ˆ ์ง€ In Vivo์˜ ํ•œ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด, NAC, D- ๋งŒ ๋…ธ์Šค์™€ Morinda(NDM)๋ฅผ ๊ฒฐํ•ฉํ–ˆ์„ ๋•Œ ์†Œ๋ณ€ ๊ฐ์—ผ ์˜ˆ๋ฐฉ์— ๋„์›€์ด ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. 2014๋…„ The World Journal of Urology์—์„œ ์‹ค์‹œ๋œ ๋‹ค๋ฅธ ํ•œ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด, D-๋งŒ๋…ธ์˜ค์Šค๊ฐ€ ์žฌ๋ฐœ์„ฑ ์š”๋กœ ๊ฐ์—ผ์˜ ์œ„ํ—˜์„ ๋ˆˆ์— ๋„๊ฒŒ ๊ฐ์†Œ ์‹œํ‚จ๋‹ค๊ณ  ๊ฒฐ๋ก  ์ง€์—ˆ์Šต๋‹ˆ๋‹ค. ๊ถŒ์žฅ ๋ณต์šฉ๋Ÿ‰ : 1,500mg 1์ผ 1-3ํšŒ

๋น„ํƒ€๋ฏผ C

1997๋…„ ํ•™๋ฌธ์ง€ Urology์—์„œ๋Š” ๊ฒฝ๊ตฌ ๋น„ํƒ€๋ฏผ C๊ฐ€ ์†Œ๋ณ€์—์„œ ์„ธ๊ท ์„ ์ฃฝ์ด๋Š” ๋ฐ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Œ์„ ๋ณด์—ฌ์ฃผ์—ˆ์Šต๋‹ˆ๋‹ค. 2007๋…„ ์—ฐ๊ตฌ์—์„œ๋Š” ์ž„์‹ ํ•œ ์—ฌ์„ฑ๋“ค์„ ๋น„๊ตํ•œ ๊ฒฐ๊ณผ, ํ•˜๋ฃจ์— ์ตœ์†Œ 100mg์˜ ๋น„ํƒ€๋ฏผ C๋ฅผ ๋ณต์šฉํ•œ ์—ฌ์„ฑ์€, ๊ทธ๋ ‡์ง€ ์•Š์€ ์—ฌ์„ฑ์— ๋น„ํ•ด ์š”๋กœ ๊ฐ์—ผ ๊ฐ€๋Šฅ์„ฑ์ด 56% ๋‚ฎ์•˜์Šต๋‹ˆ๋‹ค. ๊ถŒ์žฅ ๋ณต์šฉ๋Ÿ‰ : 1์ผ 500-1,000mg ํ˜น์€ 1์ผ 2ํšŒ.  

๋ณด์กฐ ๋ณด์ถฉ์ œ

๋ฉœ๋ผํ† ๋‹Œ

ํ•ด๊ฐ€ ์ง„ ํ›„์— ์†ก๊ณผ์„ ์— ์˜ํ•ด ๋ถ„๋น„๋˜๋Š” ๋ฉœ๋ผํ† ๋‹Œ์€ ๋‹น์‹ ์„ ์กธ๋ฆฌ๊ฒŒ ๋งŒ๋“œ๋Š” ํ˜ธ๋ฅด๋ชฌ์ž…๋‹ˆ๋‹ค. ์ผ๋ถ€๋Š” ๋ฉœ๋ผํ† ๋‹Œ ๋ณด์ถฉ์ œ๋ฅผ ๋ณต์šฉํ•จ์œผ๋กœ์จ ํšจ๊ณผ๋ฅผ ๊ฒฝํ—˜ํ•ฉ๋‹ˆ๋‹ค. ๋ฐค์— ๊นŠ์€ ์ˆ˜๋ฉด์„ ์ทจํ•˜๋„๋ก ๋•๋Š” ๋ฉœ๋ผํ† ๋‹Œ์€, 2015๋…„ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ์š”๋กœ ๊ฐ์—ผ ์˜ˆ๋ฐฉ์—๋„ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๊ถŒ์žฅ ๋ณต์šฉ๋Ÿ‰ : ๋งค์ผ ๋ฐค 3-10mg.  

๋น„ํƒ€๋ฏผ D

์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋น„ํƒ€๋ฏผ D ํ•ญ๊ท  ์„ฑ๋ถ„์„ ๊ฐ€์ง€๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ํ˜ˆ์ค‘ ๋†๋„๊ฐ€ ์ ๋‹นํ•  ๋•Œ, ๋ชธ์€ AMP(ํ•ญ๊ท  ํŽฉํƒ€์ด๋“œ)๋ผ๊ณ  ๋ถˆ๋ฆฌ๋Š” ๋‹จ๋ฐฑ์งˆ์„ ๋งŒ๋“ญ๋‹ˆ๋‹ค. AMP๋Š” ์„ธ๊ท  ๊ฐ์—ผ์„ ์˜ˆ๋ฐฉํ•˜๊ณ  ๋น„๋‡จ๊ธฐ ๊ฐ์—ผ์— ํšจ๊ณผ์  ์ผ ์ˆ˜ ์žˆ๋‹ค๊ณ  2017๋…„ Frontiers in Microbiology์˜ ํ•œ ์—ฐ๊ตฌ์—์„œ ๋ฐํ˜”์Šต๋‹ˆ๋‹ค. ๊ถŒ์žฅ ๋ณต์šฉ๋Ÿ‰ : ๋งค์ผ 2,000IU์—์„œ 5,000IU.  

L- ์•„๋ฅด๊ธฐ๋‹Œ

L- ์•„๋ฅด๊ธฐ๋‹Œ๋Š” ์ค‘์š”ํ•œ ์•„๋ฏธ๋…ธ์‚ฐ์œผ๋กœ, ์‚ฐํ™”์งˆ์†Œ(NO)์˜ ์ „๊ตฌ์ฒด์ž…๋‹ˆ๋‹ค. NO๋Š” ํ•ญ๊ท  ์„ฑ๋ถ„์„ ๊ฐ€์ง€๊ณ  ์žˆ์–ด์„œ ์š”๋กœ ๊ฐ์—ผ ์˜ˆ๋ฐฉ์— ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๊ถŒ์žฅ ๋ณต์šฉ๋Ÿ‰ : 500-1,000mg ์šฉ๋Ÿ‰์œผ๋กœ ํ•˜๋ฃจ์— 1-2ํšŒ.  

ํ”„๋กœ๋ฐ”์ด์˜คํ‹ฑ์Šค

์ผ๋ถ€ ์—ฐ๊ตฌ๋Š” ํ”„๋กœ๋ฐ”์ด์˜คํ‹ฑ์Šค๋ฅผ ์ผ์ƒ์ ์œผ๋กœ ๊ฒฝ๊ตฌ ๋ณต์šฉํ•˜๋Š” ์‚ฌ๋žŒ๋“ค์€ ์š”๋กœ ๊ฐ์—ผ ์žฌ๋ฐœ ์œ„ํ—˜์„ ์ค„์ผ ์ˆ˜ ์žˆ๋‹ค๊ณ  ๋ณด์—ฌ์คฌ์Šต๋‹ˆ๋‹ค. 2011๋…„ ์—ฐ๊ตฌ๋Š” ์งˆ ํ”„๋กœ๋ฐ”์ด์˜คํ‹ฑ ๋ณด์ถฉ์ œ๋ฅผ ์‚ฌ์šฉํ•œ ์—ฌ์„ฑ๋“ค์ด ์š”๋กœ ๊ฐ์—ผ์˜ ์˜ˆ๋ฐฉ์— ํšจ๊ณผ๋ฅผ ๋ณด์˜€๋‹ค๊ณ  ๋ฐํ˜”์Šต๋‹ˆ๋‹ค. 2013 ์—ฐ๊ตฌ๋Š” Lactobacillus๊ฐ€ ์š”๋กœ ๊ฐ์—ผ์„ ์˜ˆ๋ฐฉํ•  ์ˆ˜ ์žˆ๋‹ค๊ณ  ์ œ์•ˆํ–ˆ์Šต๋‹ˆ๋‹ค. ํ•˜์ง€๋งŒ ๋‹ค๋ฅธ ์—ฐ๊ตฌ์—์„œ๋Š” ์ด ๊ฒฐ๊ณผ๋ฅผ ์ง€์ง€ํ•˜์ง€ ์•Š์•˜์Šต๋‹ˆ๋‹ค. 2015 ๋…„ ์—ฐ๊ตฌ์—์„œ๋Š” ํ”„๋กœ๋ฐ”์ด์˜คํ‹ฑ์˜ ํšจ๊ณผ์˜ ์ฆ๊ฑฐ๊ฐ€ ์ถฉ๋ถ„ํ•˜์ง€ ์•Š๋‹ค๊ณ  ๋งํ–ˆ์Šต๋‹ˆ๋‹ค. ๊ถŒ์žฅ ๋ณต์šฉ๋Ÿ‰ : 50์–ต-1์ฒœ์–ต ๋‹จ์œ„ ์ตœ๋Œ€ ํ•˜๋ฃจ์— ๋‘ ๋ฒˆ.  

ํ•˜์ง€๋งŒ ์ €๋Š” ์˜ˆ๋ฐฉ์„ ์œ„ํ•ด ๋งค์ผ ํ•ญ์ƒ์ œ๋ฅผ ๋ณต์šฉํ•˜๊ฑฐ๋‚˜, ๊ธ‰์„ฑ ๊ฐ์—ผ์„ ์œ„ํ•ด ํ•ญ์ƒ์ œ๋ฅผ ๋ณต์šฉํ•˜๋Š” ์‚ฌ๋žŒ์—๊ฒŒ ํ”„๋กœ๋ฐ”์ด์˜คํ‹ฑ ๋ณด์ถฉ์ œ๋ฅผ ์ถ”์ฒœํ•ฉ๋‹ˆ๋‹ค. ์ด๋Š” ์ ์–ด๋„, ๊ฑด๊ฐ•ํ•œ ์žฅ์„ ๋งŒ๋“ค๋ฉด์„œ ํ•ญ์ƒ์ œ๋กœ ์ธํ•œ ์„ค์‚ฌ์™€ ํšจ๋ชจ ๊ฐ์—ผ์„ ์˜ˆ๋ฐฉํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋ฉ๋‹ˆ๋‹ค.  

ํ—ˆ๋ธŒ

ํ—ˆ๋ธŒ๋Š” ๊ฐ์ข… ์˜ํ•™์ ์ธ ์งˆ๋ณ‘์„ ์œ„ํ•ด ์ˆ˜์ฒœ ๋…„ ๋™์•ˆ ์‚ฌ์šฉ๋˜์–ด ์™”์Šต๋‹ˆ๋‹ค. ๊ณผํ•™์ž๋“ค์€ ๋งค์ผ ์ด๋“ค์˜ ์ƒˆ๋กœ์šด ์žฅ์ ์„ ๋ฐœ๊ฒฌํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค.  

Morinda Citrifolia

์ด ์•ฝ์šฉ ์‹๋ฌผ์€ ์ค‘๊ตญ ์ „ํ†ต ์˜ํ•™(TCM) ์ „๋ฌธ๊ฐ€๋“ค์ด ์ˆ˜์ฒœ ๋…„ ๋™์•ˆ ์‚ฌ์šฉํ•ด ์™”์Šต๋‹ˆ๋‹ค. ์•ฝ์ดˆ์—๋Š” 100๊ฐ€์ง€๊ฐ€ ๋„˜๋Š” ํ™œ์„ฑ ์„ฑ๋ถ„์ด ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ์ถ”์ •๋ฉ๋‹ˆ๋‹ค. 2017๋…„ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ์— ๋”ฐ๋ฅด๋ฉด D- ๋งŒ๋…ธ์˜ค์Šค, NAC, Morinda๋Š” ์—ฌ์„ฑ์˜ ์š”๋กœ ๊ฐ์—ผ์˜ ์˜ˆ๋ฐฉ ๋ฐ ์น˜๋ฃŒ์— ์œ ์šฉํ–ˆ์Šต๋‹ˆ๋‹ค.  

๋ฒ ๋ฅด๋ฒ ๋ฆฐ

2016๋…„ Microbiological Research์˜ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด, ๋ฒ ๋ฅด๋ฒ ๋ฆฐ์€ ์š”๋กœ ๊ฐ์—ผ์„ ์œ ๋ฐœํ•˜๋Š” ์ผ๋ฐ˜์ ์ธ ๋ฐ•ํ…Œ๋ฆฌ์•„(Enterococcus)๋ฅผ ์ฃฝ์ด๋Š” ๋ฐ ํšจ์œจ์ ์ด๋ผ๊ณ  ๋ฐํ˜”์Šต๋‹ˆ๋‹ค. ๊ถŒ์žฅ ๋ณต์šฉ๋Ÿ‰ : ๋ผ๋ฒจ์˜ ์ง€์‹œ๋Œ€๋กœ ๋ณต์šฉํ•˜์‹ญ์‹œ์˜ค.  

๋งˆ๋Š˜

๋งˆ๋Š˜์€ ํ•ญ๊ท  ์†์„ฑ์„ ๊ฐ€์ง€๊ณ  ์žˆ๋Š” ์ฑ„์†Œ๋กœ ์•Œ๋ ค์ ธ ์žˆ์Šต๋‹ˆ๋‹ค. ์žฌ๋ฐœ์„ฑ ์š”๋กœ ๊ฐ์—ผ์ด ์žˆ๋Š” ์‚ฌ๋žŒ๋“ค์€ ์ผ์ƒ์ •์œผ๋กœ ๋งˆ๋Š˜์„ ์„ญ์ทจํ•˜๋Š” ๊ฒƒ์ด ๊ถŒ์žฅ๋ฉ๋‹ˆ๋‹ค. 1988๋…„ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด, ํ•ญ ๋ฐ•ํ…Œ๋ฆฌ์•„ ์„ฑ์งˆ์„ ๊ฐ€์ง„ ๋งˆ๋Š˜์˜ ํ™œ์„ฑ ์„ฑ๋ถ„์€ ์•Œ๋ฆฌ์‹  (alicin) ์ž…๋‹ˆ๋‹ค. ๊ถŒ์žฅ ๋ณต์šฉ๋Ÿ‰ :  ๋ ˆ์ด๋ธ”์˜ ์ง€์‹œ๋Œ€๋กœ ๋ณต์šฉํ•˜์‹ญ์‹œ์˜ค.  

์šฐ๋ฐ” ์šฐ๋ฅด์‹œ

๋ฒ ์–ด ๋ฒ ๋ฆฌ๋กœ๋„ ์•Œ๋ ค์ง„ ์ด ํ—ˆ๋ธŒ๋Š” ์š”๋กœ ์—ผ์ฆ ์น˜๋ฃŒ๋ฅผ ์œ„ํ•ด the German Federal Institute for Drugs and Medical Device์— ์˜ํ•ด ์Šน์ธ๋˜์—ˆ๊ณ  ๋…์ผ์—์„œ ์ฒ˜๋ฐฉ๋ฐ›์„ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋‹ค๋ฅธ ์—ฐ๊ตฌ๋“ค ๋˜ํ•œ ์žฅ์ ์„ ๋ฐํ˜”์Šต๋‹ˆ๋‹ค. ๊ถŒ์žฅ ๋ณต์šฉ๋Ÿ‰ :  ๋ ˆ์ด๋ธ”์˜ ์ง€์‹œ๋Œ€๋กœ ๋ณต์šฉํ•˜์‹ญ์‹œ์˜ค.

์š”๋กœ ๊ฐ์—ผ์„ ์˜ˆ๋ฐฉํ•˜๊ณ  ์น˜๋ฃŒํ•  ์ˆ˜ ์žˆ๋Š” ๊ณผํ•™์  ์ฆ๊ฑฐ๊ฐ€ ์žˆ๋Š” ๋‹ค๋ฅธ ํ—ˆ๋ธŒ๋กœ๋Š” ๊ณจ๋“ ์‹ค, ๋ธ”๋ฃจ ๋ฒ ๋ฆฌ, ๋…น์ฐจ, ์ปคํ๋ฏผ, ๋กœ๋””์˜ฌ๋ผ์™€ ์•ค๋“œ๋กœ๊ทธ๋ผํ”ผ์Šค๊ฐ€ ์žˆ์Šต๋‹ˆ๋‹ค.  

์š”๋กœ ๊ฐ์—ผ ์˜ˆ๋ฐฉ์— ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค

์š”๋กœ ๊ฐ์—ผ์€ ์—ฌ์„ฑ์ด ๊ฒฝํ—˜ ํ•  ์ˆ˜ ์žˆ๋Š” ๊ฐ€์žฅ ํ”ํ•œ ๊ฐ์—ผ ์ค‘ ํ•˜๋‚˜์ž…๋‹ˆ๋‹ค. ๊ฐ€์žฅ ํฐ ์›์ธ์œผ๋กœ๋Š” ๋Œ€์žฅ๊ท  ๋ฐ•ํ…Œ๋ฆฌ์•„๊ฐ€ ์žˆ์Šต๋‹ˆ๋‹ค. ๊ธ‰์„ฑ ๊ฐ์—ผ์„ ์น˜๋ฃŒํ•˜๊ธฐ ์œ„ํ•ด ํ•ญ์ƒ์ œ๋ฅผ ์‚ฌ์šฉํ•˜์ง€๋งŒ, ๊ฐ์—ผ์„ ๋ฏธ๋ฆฌ ์˜ˆ๋ฐฉํ•˜๊ธฐ ์œ„ํ•ด ํ•  ์ˆ˜ ์žˆ๋Š” ๋ช‡ ๊ฐ€์ง€ ๋ฐฉ๋ฒ•์ด ์žˆ์Šต๋‹ˆ๋‹ค. ์œ„์— ๋…ผ์ด ๋œ ๋ฐฉ๋ฒ•์€ ๋งŽ์€ ์‚ฌ๋žŒ์—๊ฒŒ ๊ฐ์—ผ์„ ์˜ˆ๋ฐฉํ•  ์ˆ˜ ์žˆ๋„๋ก ํ™œ์šฉ๋ฉ๋‹ˆ๋‹ค. ์ถฉ๋ถ„ํ•œ ์ˆ˜๋ถ„ ์„ญ์ทจ, ๊ฑด๊ฐ•ํ•œ ์‹๋‹จ ๋ฐ ๊ธ์ •์ ์ธ ์ž์„ธ ๋ชจ๋‘ ํŠผํŠผํ•œ ๋ฉด์—ญ ์ฒด๊ณ„๋ฅผ ์œ„ํ•ด ์ค‘์š”ํ•ฉ๋‹ˆ๋‹ค. ๊ฑด๊ฐ•ํ•˜๊ฒŒ ๋จน๊ณ , ๊ฑด๊ฐ•ํ•˜๊ฒŒ ์ƒ๊ฐํ•˜๊ณ , ๊ฑด๊ฐ•ํ•ด์ง€์‹ญ์‹œ์˜ค!  

์ฐธ๊ณ  ๋ฌธํ—Œ :

  1. Ann Epidemiol. 2000 Nov;10(8):509-15
  2. Urol Res. 1991;19(3):177-80.
  3. Tidsskr Nor Laegeforen. 1996 Mar 10;116(7):841-3.
  4. Tze Shien Lo, Kimberly DP Hammer, Milagros Zegarra & William CS Cho Expert Review of Anti-infective Therapy Vol. 12 , Iss. 5,2014 Methenamine: a forgotten drug for preventing recurrent urinary tract infection in a multidrug resistance era
  5. Cochrane Database Syst Rev. 2004;(3):CD001209.
  6. Eells S. J., Bharadwa K., McKinnell J. A., Miller L. G. Recurrent urinary tract infections among women: comparative effectiveness of 5 prevention and management strategies using a markov chain monte carlo model. Clinical Infectious Diseases. 2014;58(2):147–160. doi: 10.1093/cid/cit646
  7. Vasileiou I, Katsargyris A, Theocharis S, Giaginis C. Current clinical status on the preventive effects of cranberry consumption against urinary tract infections. Nutr Res 2013;33:595–607.
  8. Caljouw MA, van den Hout WB, Putter H, Achterberg WP, Cools HJ, Gussekloo J. Effectiveness of cranberry capsules to prevent urinary tract infections in vulnerable older persons: a double-blind randomized placebo-controlled trial in long-term care facilities. J Am Geriatr Soc 2014;62:103–10
  9. Tao Y, Pinzón-Arango PA, Howell AB, Camesano TA. Oral Consumption of Cranberry Juice Cocktail Inhibits Molecular-Scale Adhesion of Clinical Uropathogenic Escherichia coli. Journal of Medicinal Food. 2011;14(7-8):739- 745. doi:10.1089/jmf.2010.0154.
  10. J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S96-101. doi: 10.1097/MCG.0000000000000224.
  11. MARCHIORI D, PAOLO ZANELLO P. Efficacy of N-acetylcysteine, D-mannose and Morinda citrifolia to Treat Recurrent Cystitis in Breast Cancer Survivals. In Vivo. 2017;31(5):931-936. doi:10.21873/invivo.11149.
  12. Kranjฤec B, Papeš D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol 2014;32:79. 10.1007/s00345-013- 1091-6 Urology. 1997 Aug;50(2):189-91.
  13. OCHOA-BRUST, G. J., FERNÁNDEZ, A. R., VILLANUEVA-RUIZ, G. J., VELASCO, R., TRUJILLO-HERNÁNDEZ, B. and VÁSQUEZ, C. (2007), Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancy. Acta Obstetricia et Gynecologica Scandinavica, 86: 783–787. doi:10.1080/00016340701273189
  14. Fathollahi A, Daneshgari F, Hanna-Mitchell AT. Melatonin and Its Role in Lower Urinary Tract Function: An Article Review. Current Urology. 2015;8(3):113-118. doi:10.1159/000365701.
  15. Terlizzi ME, Gribaudo G, Maffei ME. UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies. Frontiers in Microbiology. 2017;8:1566. doi:10.3389/fmicb.2017.01566.
  16. Foxman B, Buxton M. Alternative Approaches to Conventional Treatment of Acute Uncomplicated Urinary Tract Infection in Women. Current infectious disease reports. 2013;15(2):124-129. doi:10.1007/s11908-013- 0317-5.
  17. Evid Based Med. 2013 Aug;18(4):141-2. doi: 10.1136/eb-2012- 100961. Epub 2012 Nov 2.
  18. Cochrane Database Syst Rev. 2015 Dec 23;(12):CD008772. doi: 10.1002/14651858.CD008772.pub2.
  19. MARCHIORI D, PAOLO ZANELLO P. Efficacy of N-acetylcysteine, D-mannose and Morinda citrifolia to Treat Recurrent Cystitis in Breast Cancer Survivals. In Vivo. 2017;31(5):931-936. doi:10.21873/invivo.11149.
  20. Microbiol Res. 2016 May-Jun;186- 187:44-51. doi: 10.1016/j.micres.2016.03.003. Epub 2016 Mar 9.
  21. Feldberg RS, Chang SC, Kotik AN, et al. In vitro mechanism of inhibition of bacterial cell growth by allicin. Antimicrobial Agents and Chemotherapy. 1988;32(12):1763-1768.
  22. Altern Med Rev. 2008 Sep;13(3):227-44. (Discusses other studies which show the benefit of Uva-Ursi for urine infections)

๋ฉด์ฑ…์‚ฌํ•ญ:์›ฐ๋‹ˆ์Šค ํ—ˆ๋ธŒ์˜ ์ทจ์ง€๋Š” ์˜ํ•™์ ์ธ ์ง„๋‹จ์ด๋‚˜ ์น˜๋ฃŒ๋ฅผ ์ œ๊ณตํ•˜๋Š” ๊ฒƒ์ด ์•„๋‹™๋‹ˆ๋‹ค. ์ž์„ธํžˆ ์•Œ์•„๋ณด๊ธฐ