์ด ์„ธ์…˜์— ๋Œ€ํ•œ ๊ธฐ๋ณธ ์„ค์ •์ด ์—…๋ฐ์ดํŠธ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ๊ณ ๊ฐ๋‹˜์˜ ๊ณ„์ • ์„ค์ •์„ ์˜๊ตฌ์ ์œผ๋กœ ๋ณ€๊ฒฝํ•˜๋ ค๋ฉด ๋‚ด ๊ณ„์ •์œผ๋กœ ์ด๋™ํ•˜์„ธ์š”.
์›ํ•˜๋Š” ์ˆ˜๋ น ๊ตญ๊ฐ€ ๋˜๋Š” ์‚ฌ์šฉ ์–ธ์–ด๋ฅผ ๋‚ด ๊ณ„์ •์—์„œ ์–ธ์ œ๋“ ์ง€ ์—…๋ฐ์ดํŠธํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
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๊ณ ๋Œ€๋ถ€ํ„ฐ ํ—ˆ๋ธŒ๋Š” ์‹ ์ฒด๋ฅผ ์น˜์œ ํ•˜๊ณ  ๋ณ‘๊ท ์„ ์ฃฝ์ด๋ฉฐ ์˜์–‘ ์ƒํƒœ๋ฅผ ๊ฐœ์„ ํ•˜๊ณ  ๊ธฐ๋ถ„์„ ์ฆ์ง„ํ•˜๋Š” ๋ฐ ์‚ฌ์šฉ๋˜์–ด ์™”์Šต๋‹ˆ๋‹ค. ํ—ˆ๋ธŒ๋Š” ์•ฝ๋ฌผ๊ณผ ๋งˆ์ฐฌ๊ฐ€์ง€๋กœ ์˜ฌ๋ฐ”๋ฅธ ๋ฐฉ๋ฒ•์œผ๋กœ ์ ์ •๋Ÿ‰์„ ์‚ฌ์šฉํ•ด์•ผ ๋ถ€์ž‘์šฉ ์—†์ด ํšจ๋Šฅ์„ ์ œ๋Œ€๋กœ ๋ˆ„๋ฆด ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 

์ผ๋ฐ˜์ ์œผ๋กœ ํ—ˆ๋ธŒ๋Š” ์•ฝ์žฌ, ํ–ฅ์‹ ๋ฃŒ ๋˜๋Š” ํ–ฅ๋ฃŒ๋กœ ์‚ฌ์šฉํ•  ์ˆ˜ ์žˆ๋Š” ์‹๋ฌผ๋กœ ์ •์˜๋ฉ๋‹ˆ๋‹ค. ์ด ๊ธ€์—์„œ๋Š” ์•ฝ๋ฌผ ์‚ฌ์šฉ ์‹œ ํŠนํžˆ ์ฃผ์˜ํ•ด์•ผ ํ•˜๋Š” ํ—ˆ๋ธŒ๋ฅผ ์‚ดํŽด๋ด…๋‹ˆ๋‹ค.

์•ž์œผ๋กœ ์—ฌ๋Ÿฌ ๋ฒˆ์— ๊ฑธ์ณ ์–ธ๊ธ‰ํ•˜๊ฒ ์ง€๋งŒ ์ƒˆ๋กœ์šด ๋ณด์ถฉ์ œ๋ฅผ ์„ญ์ทจํ•˜๋ ค ํ•  ๋•Œ๋Š” ํ•ญ์ƒ ์˜์‚ฌ์—๊ฒŒ ๊ทธ ์‚ฌ์‹ค์„ ์•Œ๋ ค์•ผ ํ•˜๋ฉฐ ์ƒˆ๋กœ์šด ํ—ˆ๋ธŒ ์•ฝ์ œ๋ฅผ ์‚ฌ์šฉํ•˜๊ธฐ ์ „์— ํ—ˆ๋ธŒ ์ „๋ฌธ๊ฐ€๋‚˜ ์ž์—ฐ์š”๋ฒ• ์˜์‚ฌ์™€ ์ƒ๋‹ดํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค. 

์‹๋ฃŒํ’ˆ์ ์ด๋‚˜ ์˜จ๋ผ์ธ์—์„œ ํŒ๋งคํ•˜๋Š” ๋‹ค์–‘ํ•œ ํ—ˆ๋ธŒ๋Š” ์•ฝ๋ฌผ๊ณผ ํ•จ๊ป˜ ๋ณ‘์šฉํ•˜๊ฑฐ๋‚˜ ๊ธฐ์ € ์งˆํ™˜์ด ์žˆ๋Š” ์‚ฌ๋žŒ์ด ์„ญ์ทจํ•  ๊ฒฝ์šฐ ์œ„ํ—˜ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ํ—ˆ๋ธŒ๋Š” ์•„๋ž˜์—์„œ ์„ค๋ช…ํ•ด ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ์˜์‚ฌ, ํ—ˆ๋ธŒ ์ „๋ฌธ๊ฐ€, ์˜์–‘์‚ฌ๋Š” ํ—ˆ๋ธŒ๋ฅผ ์•ˆ์ „ํ•˜๊ฒŒ ์‚ฌ์šฉํ•˜๋Š” ๋ฐฉ๋ฒ•์— ๋Œ€ํ•œ ์ „๋ฌธ ๊ต์œก์„ ๋ฐ›์Šต๋‹ˆ๋‹ค. ์ด๋“ค์˜ ์ˆ™๋ จ๋œ ์ง€์‹์„ ์ž˜ ํ™œ์šฉํ•˜๋ฉด ์ตœ๊ณ ์˜ ๊ฑด๊ฐ•ํ•œ ์‚ถ์„ ๋ˆ„๋ฆด ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 

1. ๊ฐ์ดˆ ๋ฟŒ๋ฆฌ์™€ ์‹ฌ์žฅ์•ฝ

๊ฐ์ดˆ ๋ฟŒ๋ฆฌ๋Š” ํ•ญ์—ผ, ๊ฐ•์žฅ, ํ•ญ๊ท  ๋“ฑ ๋‹ค์–‘ํ•œ ํšจ๋Šฅ์ด ์žˆ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ ๊ฐ์ดˆ ๋ฟŒ๋ฆฌ๋Š” ์—ผ๋ถ„ ์ €๋ฅ˜๋ฅผ ์ด‰์ง„ํ•˜์—ฌ ํ˜ˆ์••์„ ๋†’์ด๋ฏ€๋กœ ์ €ํ˜ˆ์••์„ ์น˜๋ฃŒํ•˜๋Š” ๋ฐ ํฐ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์ง€๋งŒ ๊ณ ํ˜ˆ์••์ด ์žˆ๋Š” ์‚ฌ๋žŒ์—๊ฒŒ๋Š” ์œ„ํ—˜ํ•ฉ๋‹ˆ๋‹ค. 

๊ฐ์ดˆ ๋ฟŒ๋ฆฌ๋Š” ์‹๋ฃŒํ’ˆ์ ์—์„œ ํŒŒ๋Š” ์ฐจ ์ œํ’ˆ, ์ฒ˜๋ฐฉ์ด ํ•„์š” ์—†๋Š” ํŒ…ํฌ ๋ฐ ์˜์•ฝํ’ˆ์— ์ผ๋ฐ˜์ ์œผ๋กœ ํ•จ์œ ๋˜๋Š” ์„ฑ๋ถ„์ด๋ฉฐ ๊ฐ๊ธฐ ๋ฐ ๋…๊ฐ, ํ•ญ์—ผ์ฆ์ œ, ๋””ํ†ก์Šค ์ œํ’ˆ ๋“ฑ์— ์ฒจ๊ฐ€๋˜๋Š” ๊ฒฝ์šฐ๊ฐ€ ๋งŽ์Šต๋‹ˆ๋‹ค. ๊ฐ์ดˆ ๋ฟŒ๋ฆฌ๋Š” ์ œํ’ˆ ๋ผ๋ฒจ์— ๋‹จ์ˆœํžˆ '๊ฐ์ดˆ(Licorice)'๊ฐ€ ์•„๋‹Œ ๊ธ€๋ฆฌ์‹œ๋ฆฌ์ž ๊ธ€๋ผ๋ธŒ๋ผ(Glycyrrhiza glabra)๋ผ๋Š” ํ•™๋ช…์œผ๋กœ ํ‘œ์‹œ๋  ๋•Œ๋„ ์žˆ์–ด ํ•จ์œ  ์—ฌ๋ถ€๋ฅผ ํ™•์ธํ•˜๊ธฐ๊ฐ€ ๊นŒ๋‹ค๋กœ์šธ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๊ณ ํ˜ˆ์••์ด ์žˆ๋Š” ์‚ฌ๋žŒ์€ ์ œํ’ˆ์„ ๊ตฌ๋งคํ•  ๋•Œ ์„ฑ๋ถ„ํ‘œ๋ฅผ ๊ผผ๊ผผํžˆ ์ฝ๊ณ  ์ง‘์— ์žˆ๋Š” ์ฐจ ์ œํ’ˆ์˜ ํฌ์žฅ๋„ ์‚ดํŽด๋ด์„œ ๊ฐ์ดˆ๋‚˜ ๊ธ€๋ฆฌ์‹œ๋ฆฌ์ž ์„ฑ๋ถ„์ด ์ฒจ๊ฐ€๋˜์—ˆ๋Š”์ง€ ํ™•์ธํ•  ํ•„์š”๊ฐ€ ์žˆ์Šต๋‹ˆ๋‹ค. ๊ณ ํ˜ˆ์•• ํ™˜์ž์˜ ๊ฒฝ์šฐ ๊ฐ์ดˆ๋Š” ์ด๋‡จ์ œ ๋ฐ ์‹ฌ์žฅ์•ฝ์˜ ์ž‘์šฉ์„ ๋ฐฉํ•ดํ•˜๊ฑฐ๋‚˜ ์•ฝํšจ๋ฅผ ๊ฐ์†Œ์‹œํ‚ฌ ์ˆ˜ ์žˆ์œผ๋ฉฐ ์‹ฌํ˜ˆ๊ด€ ์งˆํ™˜์„ ์œ ๋ฐœํ•  ์œ„ํ—˜์ด ์žˆ๊ธฐ ๋•Œ๋ฌธ์ž…๋‹ˆ๋‹ค.

๊ณ ํ˜ˆ์••, ์‹ฌํ˜ˆ๊ด€ ์งˆํ™˜, ์ฒด์•ก ์ €๋ฅ˜ ์ฆ์ƒ์ด ์žˆ๋Š” ์‚ฌ๋žŒ์€ ๊ฐ์ดˆ๋ฅผ ํ”ผํ•˜๋Š” ๊ฒƒ์ด ์ข‹์Šต๋‹ˆ๋‹ค. ๋‹จ, ๊ธ€๋ฆฌ์‹œ๋ฆฌ์ง„(Glycyrrhizin)์„ ์ œ๊ฑฐํ•œ ๊ฐ์ดˆ(Deglycyrrhized licorice, DGL)๋Š” ์˜ˆ์™ธ์ž…๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ์œ ํ˜•์˜ ๊ฐ์ดˆ๋Š” ์—ผ๋ถ„ ์ €๋ฅ˜๋ฅผ ์œ ๋ฐœํ•˜๋Š” ์„ฑ๋ถ„์ธ ๊ธ€๋ฆฌ์‹œ๋ฆฌ์ง„์„ ์ œ๊ฑฐํ•˜๋Š” ๊ณผ์ •์„ ๊ฑฐ์ณ ๋งŒ๋“ญ๋‹ˆ๋‹ค. ๊ณ ํ˜ˆ์••์ด ์žˆ์ง€๋งŒ ๊ฐ์ดˆ๋ฅผ ์„ญ์ทจํ•˜๊ณ  ์‹ถ์€ ์‚ฌ๋žŒ์—๊ฒŒ๋Š” ์ด๋Ÿฌํ•œ ๊ธ€๋ฆฌ์‹œ๋ฆฌ์ง„์„ ์ œ๊ฑฐํ•œ ๊ฐ์ดˆ๊ฐ€ ์•ˆ์ „ํ•œ ์„ ํƒ์ผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ƒˆ๋กœ์šด ํ—ˆ๋ธŒ ์•ฝ์ œ๋ฅผ ์‚ฌ์šฉํ•˜๋ ค ํ•  ๋•Œ๋Š” ์–ธ์ œ๋‚˜ ์˜์‚ฌ์™€ ์ƒ๋‹ดํ•˜๋Š” ๊ฒƒ์ด ์ข‹์œผ๋ฉฐ ํŠนํžˆ ๋‹ค๋ฅธ ์•ฝ๋ฌผ์„ ์ด๋ฏธ ๋ณต์šฉ ์ค‘์ด๋ผ๋ฉด ์˜์‚ฌ์˜ ์ง€์‹œ๋ฅผ ๋”ฐ๋ฅด๋Š” ๊ฒƒ์ด ๋”์šฑ ์ค‘์š”ํ•ฉ๋‹ˆ๋‹ค. 

2. ์„ธ์ธํŠธ ์กด์Šค ์›ŒํŠธ์™€ ํ•ญ์šฐ์šธ์ œ

ํ•ญ๋ฐ”์ด๋Ÿฌ์Šค ๋ฐ ๊ธฐ๋ถ„ ์ฆ์ง„ ํšจ๋Šฅ์ด ์žˆ๋Š” ์œ ์šฉํ•œ ์‹๋ฌผ์ธ ์„ธ์ธํŠธ ์กด์Šค ์›ŒํŠธ(St. Johnโ€™s wort)๋ฅผ ์‚ฌ์šฉํ•  ๋•Œ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™์€ 2๊ฐ€์ง€์˜ ๋ถ€์ž‘์šฉ์„ ์ฃผ์˜ํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค.  ์ฒซ์งธ, ์„ธ์ธํŠธ ์กด์Šค ์›ŒํŠธ๋Š” ์„ธ๋กœํ† ๋‹Œ(Serotonin) ์กฐ์ ˆ ์•ฝ๋ฌผ ๋˜๋Š” ๋ชจ๋…ธ์•„๋ฏผ ์‚ฐํ™”ํšจ์†Œ(Monoamine oxidase, MAO) ์ˆ˜์šฉ์ฒด ์กฐ์ ˆ ์•ฝ๋ฌผ(ํ•ญ์šฐ์šธ์ œ, ํ•ญ๊ฒฝ๋ จ์ œ, ์ง€์‚ฌ์ œ ๋“ฑ)๊ณผ ๋ณ‘์šฉํ•  ๊ฒฝ์šฐ ์„ธ๋กœํ† ๋‹Œ ์ฆํ›„๊ตฐ์ด ์ƒ๊ธธ ์œ„ํ—˜์ด ์žˆ์Šต๋‹ˆ๋‹ค. ์„ธ๋กœํ† ๋‹Œ ์ฆํ›„๊ตฐ์€ ์ ์ ˆํ•˜๊ฒŒ ์น˜๋ฃŒํ•˜์ง€ ์•Š์œผ๋ฉด ๋ฐœ์ž‘, ๋ฐœ์—ด, ๊ทผ์œก ๊ฒฝ์ง, ๋–จ๋ฆผ, ์œ„์žฅ ์žฅ์•  ๋“ฑ์˜ ์ฆ์ƒ์ด ๋ฐœ์ƒํ•˜๋ฉฐ ์‹ฌํ•˜๋ฉด ์‚ฌ๋งํ•  ์ˆ˜๋„ ์žˆ์Šต๋‹ˆ๋‹ค. ๋‘˜์งธ, ์„ธ์ธํŠธ ์กด์Šค ์›ŒํŠธ๋Š” ํ”ผ์ž„์ œ์˜ ๋Œ€์‚ฌ๋ฅผ ์ด‰์ง„ํ•˜์—ฌ ๋Œ๋ฐœ์ถœํ˜ˆ(Breakthrough bleeding), ํ˜ธ๋ฅด๋ชฌ ๋ฌธ์ œ, ํ”ผ์ž„ ํšจ๊ณผ ๊ฐ์†Œ์™€ ๊ฐ™์€ ๋ถ€์ž‘์šฉ์„ ์œ ๋ฐœํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์„ธ์ธํŠธ ์กด์Šค ์›ŒํŠธ๋กœ ๊ธฐ๋ถ„์žฅ์• ๋ฅผ ์น˜๋ฃŒํ•˜๊ฑฐ๋‚˜ ์งˆํ™˜์„ ์˜ˆ๋ฐฉํ•˜๋ ค ํ•˜๋Š” ์‚ฌ๋žŒ์€ ๋จผ์ € ์˜์‚ฌ์—๊ฒŒ ์š”์ฒญํ•˜์—ฌ ๋น„ํƒ€๋ฏผD์™€ ์ฒ ๋ถ„๋น„ํƒ€๋ฏผB12 ์ˆ˜์น˜๋ฅผ ํ™•์ธํ•ด ๋ณด์‹ญ์‹œ์˜ค. ์‹ค์ œ๋กœ ์˜์–‘์†Œ๊ฐ€ ๊ฒฐํ•๋œ ์ƒํƒœ๋ผ๋ฉด ๋Œ€๋ถ€๋ถ„์˜ ๊ฒฝ์šฐ ์„ธ์ธํŠธ ์กด์Šค ์›ŒํŠธ๋ฅผ ์‚ฌ์šฉํ•  ํ•„์š” ์—†์ด ์•ˆ์ „ํ•˜๊ฒŒ ๊ธฐ๋ถ„๊ณผ ๋ฉด์—ญ ๊ธฐ๋Šฅ์„ ์ฆ์ง„ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ์ด๋Ÿฌํ•œ ์˜์–‘ ๊ฒฐํ•์„ ๊ฐœ์„ ํ•˜๋Š” ๋ณด์ถฉ์ œ๋Š” ๋Œ€๋ถ€๋ถ„์˜ ์•ฝ๋ฌผ๊ณผ ์•ˆ์ „ํ•˜๊ฒŒ ๋ณ‘์šฉํ•  ์ˆ˜ ์žˆ๋Š” ์žฅ์ ์ด ์žˆ์Šต๋‹ˆ๋‹ค.

3. ์€ํ–‰๋‚˜๋ฌด์™€ ์•„์Šคํ”ผ๋ฆฐ

์€ํ–‰๋‚˜๋ฌด๊ฐ€ ์ •์‹  ๊ฑด๊ฐ•, ์ธ์ง€๋ ฅ, ์‹ฌํ˜ˆ๊ด€ ๊ฑด๊ฐ•์— ๋ฏธ์น˜๋Š” ๊ธ์ •์ ์ธ ์˜ํ–ฅ์€ ์ง€๊ธˆ๊นŒ์ง€ ๋งŽ์€ ์—ฐ๊ตฌ์˜ ์ฃผ์ œ๊ฐ€ ๋˜์–ด ์™”์Šต๋‹ˆ๋‹ค. ํ•˜์ง€๋งŒ ์€ํ–‰๋‚˜๋ฌด๋Š” ์™€ํŒŒ๋ฆฐ(Warfarin), ์•„์Šคํ”ผ๋ฆฐ๊ณผ ๊ฐ™์€ ์•ฝ๋ฌผ์˜ ์ž‘์šฉ์„ ๋ฐฉํ•ดํ•  ์ˆ˜ ์žˆ์œผ๋ฉฐ ์ด ๋‘ ์•ฝ๋ฌผ๊ณผ ํ•จ๊ป˜ ๋ณ‘์šฉํ•  ๊ฒฝ์šฐ ๊ณผ๋„ํ•œ ์ถœํ˜ˆ์ด ๋ฐœ์ƒํ•  ์œ„ํ—˜์ด ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ์•Œ๋ ค์ ธ ์žˆ์Šต๋‹ˆ๋‹ค. ์€ํ–‰๋‚˜๋ฌด ๋ณด์ถฉ์ œ๋ฅผ ์„ญ์ทจํ•˜๋ ค ํ•œ๋‹ค๋ฉด ์˜์‚ฌ์™€ ์ƒ๋‹ดํ•˜๊ณ  ํŠนํžˆ ์•„์Šคํ”ผ๋ฆฐ ๋˜๋Š” ์™€ํŒŒ๋ฆฐ์„ ์‚ฌ์šฉ ์ค‘์ด๊ฑฐ๋‚˜ ์‹ฌํ˜ˆ๊ด€ ์งˆํ™˜์ด ์žˆ๊ฑฐ๋‚˜ ์ถœํ˜ˆ ๋˜๋Š” ์‘๊ณ  ์žฅ์• ๊ฐ€ ์žˆ๋Š” ๊ฒฝ์šฐ ์„ญ์ทจํ•˜๊ธฐ ์ „์— ์˜์‚ฌ์—๊ฒŒ ๋ฌธ์˜ํ•˜์‹ญ์‹œ์˜ค. ๋˜ํ•œ ์€ํ–‰๋‚˜๋ฌด ๋Œ€์‹  ์•ฝ๋ฌผ ์ƒํ˜ธ์ž‘์šฉ์„ ์ผ์œผํ‚ค์ง€ ์•Š๋Š” ๋ฐ”์ฝ”ํŒŒ(Bacopa), ๋ฒ ๋ฆฌ๋ฅ˜ ๊ฐ™์€ ๋ˆ„ํŠธ๋กœํ”ฝ(Nootropics, ๋‡Œ ๊ธฐ๋Šฅ ์ฆ์ง„์ œ)์ด๋‚˜ ํ˜ˆ๊ด€ ๊ฐ•์žฅ์ œ๋ฅผ ์‚ฌ์šฉํ•˜๋Š” ๊ฒƒ๋„ ์ข‹์Šต๋‹ˆ๋‹ค.

4. ์ฒœ์—ฐ ์™„ํ•˜์ œ: ์„ผ๋‚˜์™€ ์นด์Šค์นด๋ผ

์„ผ๋‚˜(Senna)์นด์Šค์นด๋ผ ์‚ฌ๊ทธ๋ผ๋‹ค(Cascara sagrada)๊ฐ™์ด ์™„ํ•˜ ํšจ๊ณผ๊ฐ€ ์žˆ๋Š” ํ—ˆ๋ธŒ๋Š” ๊ฐ„ ์ง€์›, ์‹ ์žฅ ์ง€์›, ์žฅ ์ง€์› ๋“ฑ์˜ ํšจ๋Šฅ์ด ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ํ‘œ์‹œ๋œ ๋น„์ฒ˜๋ฐฉ ํ—ˆ๋ธŒ ๋ฐฐํ•ฉ ์ œํ’ˆ์— ์ฒจ๊ฐ€๋œ ๊ฒฝ์šฐ๊ฐ€ ๋งŽ์Šต๋‹ˆ๋‹ค. ์Œ์‹๋ฌผ์ด ์†Œํ™”๊ธฐ๋ฅผ ๋นจ๋ฆฌ ํ†ต๊ณผํ•˜๋„๋ก ๋•๋Š” ์ด๋Ÿฌํ•œ ์ฒœ์—ฐ ์™„ํ•˜์ œ๋Š” ๋‹จ๊ธฐ์ ์œผ๋กœ ์‚ฌ์šฉํ•˜๋Š” ๊ฒƒ์€ ๊ดœ์ฐฎ์ง€๋งŒ 3์ผ ๋„˜๊ฒŒ ์—ฐ์†์œผ๋กœ ์„ญ์ทจํ•˜๊ฑฐ๋‚˜ 2์ฃผ ์ด์ƒ ์ง€์†์ ์œผ๋กœ ์‚ฌ์šฉํ•ด์„œ๋Š” ์•ˆ ๋ฉ๋‹ˆ๋‹ค. ๋‹ค๋ฅธ ์™„ํ•˜์ œ๋„ ๋งˆ์ฐฌ๊ฐ€์ง€์ง€๋งŒ ์ฒœ์—ฐ ์™„ํ™”์ œ๋Š” ์žฅ์—์„œ ํ‰์†Œ๋ณด๋‹ค ๋งŽ์€ ์ „ํ•ด์งˆ์„ ๊ฐ•์ œ๋กœ ๋ถ„๋น„ํ•˜๋„๋ก ํ•˜๋Š” ์ž‘์šฉ์„ ํ•˜๊ธฐ ๋•Œ๋ฌธ์ž…๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ์ž‘์šฉ์ด ์ง€์†๋˜๋ฉด ํƒˆ์ˆ˜ ๋ฐ ์ „ํ•ด์งˆ ์žฅ์• ๊ฐ€ ๋ฐœ์ƒํ•ด ์‹ฌ์žฅ, ๋‡Œ, ๊ธฐํƒ€ ๊ธฐ๊ด€์˜ ์ „๊ธฐ ์‹ ํ˜ธ ์ „๋‹ฌ์— ์˜ํ–ฅ์ด ์ƒ๊ธธ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ ์™„ํ•˜์ œ๋Š” ๊ฒฝ๊ตฌ์šฉ ์•ฝ๋ฌผ์˜ ํก์ˆ˜์— ์˜ํ–ฅ์„ ๋ฏธ์น  ์ˆ˜ ์žˆ์œผ๋ฉฐ ์œ„์žฅ ์ฆ์ƒ์„ ๊ฐœ์„ ํ•˜๊ธฐ ์œ„ํ•œ ์•ฝ๋ฌผ์˜ ํšจ๊ณผ๋ฅผ ๊ฐ์†Œ์‹œํ‚ฌ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋ณ€๋น„๊ฐ€ ์žˆ๋Š” ์‚ฌ๋žŒ์€ ๋งˆ๊ทธ๋„ค์Š˜ ๋˜๋Š” ๋น„ํƒ€๋ฏผC ๊ฐ™์€ ๋ณด์ถฉ์ œ๊ฐ€ ๋‹ค๋ฅธ ์•ฝ๋ฌผ๊ณผ์˜ ์ƒํ˜ธ์ž‘์šฉ์ด๋‚˜ ํƒˆ์ˆ˜ ๋“ฑ์˜ ๋ถ€์ž‘์šฉ ์—†์ด ๋ณ€๋น„๋ฅผ ๊ฐœ์„ ํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์„์ง€ ์˜์‚ฌ์™€ ์ƒ๋‹ดํ•˜์‹ญ์‹œ์˜ค. ์•ˆ์ „ํ•œ ๊ฐ„ ๋””ํ†ก์Šค ๋ฐฉ๋ฒ•์„ ์ฐพ๊ณ  ์žˆ๋‹ค๋ฉด ์„ฌ์œ ์†Œ์™€ ๋ฌผ์„ ๋งŽ์ด ์„ญ์ทจํ•˜๋Š” ์Šต๊ด€๋ถ€ํ„ฐ ๋“ค์ด์‹ญ์‹œ์˜ค. 

5. ์ค‘์ถ”์‹ ๊ฒฝ๊ณ„๋ฅผ ์กฐ์ ˆํ•˜๋Š” '์ €์šฉ๋Ÿ‰ ํ—ˆ๋ธŒ'

์ด ์œ ํ˜•์˜ ํ—ˆ๋ธŒ๋Š” ์ž˜๋ชป ์‚ฌ์šฉํ•˜๋ฉด ์‹ฌ๊ฐํ•œ ๋ถ€์ž‘์šฉ์ด ์ƒ๊ธฐ๊ฑฐ๋‚˜ ์‚ฌ๋งํ•  ์ˆ˜๋„ ์žˆ์–ด ์•„์ฃผ ์ ์€ ์–‘์„ ์‚ฌ์šฉํ•ด์•ผ ํ•˜๋ฏ€๋กœ '์ €์šฉ๋Ÿ‰ ํ—ˆ๋ธŒ'๋ผ๊ณ  ๋ถˆ๋ฆฝ๋‹ˆ๋‹ค. ์˜์•ฝํ’ˆ์ด ๋ฐœ๋ช…๋˜๊ธฐ ์ „ ํ—ˆ๋ธŒ์˜ ํ™”ํ•™์  ๊ตฌ์กฐ์— ๋Œ€ํ•œ ์ดํ•ด๊ฐ€ ๋ถ€์กฑํ–ˆ๋˜ ๊ณผ๊ฑฐ์— ์ด๋Ÿฌํ•œ ํ—ˆ๋ธŒ๋Š” ๋Œ€๋ถ€๋ถ„ ์ง„ํ†ต์ œ๋กœ ์‚ฌ์šฉ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ์ €์šฉ๋Ÿ‰ ํ—ˆ๋ธŒ๋ฅผ ์‚ฌ์šฉํ•˜๋ ค๋ฉด ์•„์ฃผ ์ˆ™๋ จ๋œ ์ „๋ฌธ๊ฐ€์˜ ๋„์›€์„ ๋ฐ›์•„ ์ž์‹ ์—๊ฒŒ ์ ํ•ฉํ•œ ์šฉ๋Ÿ‰์„ ์•„๋Š” ๊ฒƒ์ด ์ค‘์š”ํ•ฉ๋‹ˆ๋‹ค. ๋œ ์œ„ํ—˜ํ•œ ๋‹ค๋ฅธ ๋Œ€์•ˆ์„ ๊ณ ๋ คํ•˜๋Š” ๊ฒƒ๋„ ํ•œ ๋ฐฉ๋ฒ•์ž…๋‹ˆ๋‹ค. ์ €์šฉ๋Ÿ‰์œผ๋กœ ์‚ฌ์šฉํ•ด์•ผ ํ•˜๋Š” ํ—ˆ๋ธŒ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค.

์ด๋Ÿฌํ•œ ํ—ˆ๋ธŒ ๋Œ€๋ถ€๋ถ„์€ ์‹ ๊ฒฝ๊ณ„์— ์˜ํ–ฅ์„ ๋ฏธ์น˜๋ฏ€๋กœ ๊ธฐ๋ถ„, ํ†ต์ฆ, ๋ฐœ์ž‘ ๋“ฑ์„ ์น˜๋ฃŒํ•˜๋Š” ๋ฐ ์‚ฌ์šฉํ•˜๋Š” ์•ฝ๋ฌผ๊ณผ ์ƒํ˜ธ์ž‘์šฉํ•˜๊ฑฐ๋‚˜ ์•ฝํšจ๋ฅผ ๋–จ์–ด๋œจ๋ฆด ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ด ์œ ํ˜•์˜ ํ—ˆ๋ธŒ๋Š” ์˜์‚ฌ์™€์˜ ์ƒ๋‹ด ์—†์ด ์ ˆ๋Œ€ ํ˜ผ์ž ๊ฒฐ์ •ํ•ด์„œ ์„ญ์ทจํ•˜๋ฉด ์•ˆ ๋ฉ๋‹ˆ๋‹ค.

6. ๊ฐ„์— ๋ถ€๋‹ด์„ ์ฃผ๋Š” ํ—ˆ๋ธŒ

๋ชจ๋“  ์˜์•ฝํ’ˆ๊ณผ ์•ฝ์žฌ๋Š” ๊ฐ„์—์„œ ๋Œ€์‚ฌ๊ฐ€ ์ด๋ฃจ์–ด์ง‘๋‹ˆ๋‹ค. ์ผ๋ถ€ ํ—ˆ๋ธŒ ์•ฝ์žฌ๋Š” ์ž˜๋ชป๋œ ์ œ์กฐ๊ณต์ • ๋ฐ ํ’ˆ์งˆ๊ด€๋ฆฌ๋กœ ์ธํ•ด ๊ณฐํŒก์ด๋‚˜ ๋ฐ•ํ…Œ๋ฆฌ์•„, ์ค‘๊ธˆ์†์— ์˜ค์—ผ๋˜๊ฑฐ๋‚˜ ์˜ค๋žœ ๊ธฐ๊ฐ„ ๋™์•ˆ์ด๋‚˜ ๊ณผ๋„ํ•œ ์–‘์„ ์‚ฌ์šฉํ•˜๋Š” ๊ฒฝ์šฐ ๊ฐ„์„ ๋ง๊ฐ€๋œจ๋ฆด ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.

๊ฐ„ ์†์ƒ์„ ์ผ์œผํ‚ฌ ์ˆ˜ ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ์•Œ๋ ค์ง„ ํ—ˆ๋ธŒ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค.

์ด๋Ÿฌํ•œ ํ—ˆ๋ธŒ๋“ค์€ ์ „๋ฌธ๊ฐ€์˜ ๋„์›€์„ ๋ฐ›์œผ๋ฉด ์•ˆ์ „ํ•˜๊ฒŒ ์„ญ์ทจํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์‚ฌ์šฉํ•˜๊ธฐ ์ „์— ์˜์‚ฌ์™€ ์ƒ๋‹ดํ•˜์—ฌ ์–ด๋–ค ํ˜•ํƒœ๋กœ ์–ผ๋งˆ๋‚˜ ์„ญ์ทจํ•ด์•ผ ํ•˜๋Š”์ง€์— ๋Œ€ํ•ด ์กฐ์–ธ์„ ๋ฐ›์œผ์‹ญ์‹œ์˜ค. 

์ด ์œ ํ˜•์— ์†ํ•˜๋Š” ํ—ˆ๋ธŒ๋Š” ์ด์™ธ์—๋„ ๋งŽ์Šต๋‹ˆ๋‹ค. ์ „๋ฌธ๊ฐ€์˜ ์ง€์‹œ ์—†์ด ํ—ˆ๋ธŒ๋ฅผ ํ•˜๋ฃจ์— ์ˆ˜์ฐจ๋ก€ ๋˜๋Š” ๋ช‡ ์ฃผ๊ฐ„ ์—ฐ์†์œผ๋กœ ์„ญ์ทจํ•˜๋Š” ๊ฒƒ์€ ํ”ผํ•˜์‹ญ์‹œ์˜ค. ์–ด๋–ค ํ—ˆ๋ธŒ๋“  ๊ณผ๋„ํ•˜๊ฒŒ ์„ญ์ทจํ•˜๋ฉด ๊ฐ„์„ ์†์ƒ์‹œํ‚ฌ ์ˆ˜ ์žˆ๊ธฐ ๋•Œ๋ฌธ์ž…๋‹ˆ๋‹ค. ์ด ์ฃผ์ œ์— ๊ด€ํ•ด ๋” ์ž์„ธํžˆ ์•Œ๊ณ  ์‹ถ์œผ๋ฉด ํŽ๋ฉ”๋“œ(PubMed)์—์„œ 'ํ—ˆ๋ธŒ๋กœ ์ธํ•œ ๊ฐ„ ์†์ƒ(Herb-induced liver injury)'์„ ํ‚ค์›Œ๋“œ๋กœ ํ•˜์—ฌ ๊ฒ€์ƒ‰ํ•ด ๋ณด์‹ญ์‹œ์˜ค.

7. ์ž๋ชฝ ์„ญ์ทจ ์‹œ ์ฃผ์˜ ์‚ฌํ•ญ 

์—„๋ฐ€ํžˆ ๋งํ•ด ์ž๋ชฝ์€ ํ—ˆ๋ธŒ๊ฐ€ ์•„๋‹ˆ์ง€๋งŒ ์—ฌ๊ธฐ์„œ ์–ธ๊ธ‰ํ•˜๋Š” ์ด์œ ๋Š” ๋ฏธ๊ตญ์—์„œ 20% ์ด์ƒ์˜ ๊ฐ€์ •์ด, ์ „ ์„ธ๊ณ„์ ์œผ๋กœ๋Š” ๊ทธ ์ด์ƒ์ด ์ž๋ชฝ ์ฃผ์Šค๋ฅผ ์Œ๋ฃŒ์ˆ˜๋กœ ๋งˆ์‹œ๊ณ  ์žˆ๊ธฐ ๋•Œ๋ฌธ์ž…๋‹ˆ๋‹ค. ์ž๋ชฝ์€ ๊ฐ„ ๋ฐ ์žฅ ํšจ์†Œ์™€ ์ƒํ˜ธ์ž‘์šฉํ•˜์—ฌ ํ˜ˆ์ค‘ ์•ฝ๋ฌผ ๋†๋„๋ฅผ ๋†’์ผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค  

์ด๋Ÿฐ ์•ฝ๋ฌผ ์ƒํ˜ธ์ž‘์šฉ์ด ๋ฐœ์ƒํ•˜๋ฉด ์ •์ƒ ์šฉ๋Ÿ‰์œผ๋กœ ์•ฝ๋ฌผ์„ ์‚ฌ์šฉํ•˜๋”๋ผ๋„ ๊ฒฐ๊ณผ์ ์œผ๋กœ ์•ฝ์„ ๊ณผ์šฉํ•˜๊ฑฐ๋‚˜ ๊ณผ์†Œ ๋ณต์šฉํ•œ ์ƒํƒœ๊ฐ€ ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์•ฝ๋ฌผ ์ƒํ˜ธ์ž‘์šฉ์ด ์ผ์–ด๋‚  ๊ฐ€๋Šฅ์„ฑ์„ ์ค„์ด๋ ค๋ฉด ๋ช‡ ์‹œ๊ฐ„์˜ ๊ฐ„๊ฒฉ์„ ๋‘๊ณ  ์•ฝ๋ฌผ๊ณผ ์ž๋ชฝ์„ ์„ญ์ทจํ•˜๊ณ  ์ž๋ชฝ ๋˜๋Š” ์ž๋ชฝ ์ฃผ์Šค์™€ ํ•จ๊ป˜ ํŠน์ • ์ฒ˜๋ฐฉ์•ฝ์„ ๋ณต์šฉํ•ด๋„ ๊ดœ์ฐฎ์€์ง€ ์˜์‚ฌ์—๊ฒŒ ๋ฌธ์˜ํ•˜์‹ญ์‹œ์˜ค.

๊ฒฐ๋ก 

์ง€๊ธˆ๊นŒ์ง€ ์•ฝ๋ฌผ๊ณผ ์ƒํ˜ธ์ž‘์šฉํ•  ์ˆ˜ ์žˆ๋Š” ํ—ˆ๋ธŒ์— ๋Œ€ํ•ด ์„ค๋ช…ํ•ด ๋“œ๋ ธ๋Š”๋ฐ ์˜ฌ๋ฐ”๋ฅธ ๋ฐฉ๋ฒ•๊ณผ ์ง€์‹œ์— ๋”ฐ๋ผ ์„ญ์ทจํ•˜๋ฉด ์•ˆ์ „ํ•˜๊ณ  ๊ฑด๊ฐ•์— ์œ ์ตํ•œ ํ—ˆ๋ธŒ๋Š” ๋ฌด์ˆ˜ํžˆ ๋งŽ์Šต๋‹ˆ๋‹ค. ์ƒˆ๋กœ์šด ํ—ˆ๋ธŒ ์•ฝ์ œ๋‚˜ ๋ณด์ถฉ์ œ๋ฅผ ์„ญ์ทจํ•˜๋ ค ํ•  ๋•Œ๋Š” ํ•ญ์ƒ ์˜์‚ฌ์—๊ฒŒ ๊ทธ ์‚ฌ์‹ค์„ ์•Œ๋ ค์•ผ ํ•˜๋ฉฐ ์ž์‹ ์—๊ฒŒ ๋งž๋Š” ํ—ˆ๋ธŒ๋ฅผ ๊ณ ๋ฅด๋ ค๋ฉด ํ—ˆ๋ธŒ ์ „๋ฌธ๊ฐ€๋‚˜ ์ž์—ฐ์š”๋ฒ• ์˜์‚ฌ์˜ ์กฐ์–ธ์„ ๊ตฌํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค. ํ—ˆ๋ธŒ๋Š” ์•ฝ์ž…๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ ํ—ˆ๋ธŒ๋ฅผ ์•ˆ์ „ํ•˜๊ฒŒ ์‚ฌ์šฉํ•˜์—ฌ ์ตœ๊ณ ์˜ ํšจ๊ณผ๋ฅผ ์–ป๊ธฐ ์œ„ํ•ด์„œ๋Š” ํ—ˆ๋ธŒ๋ฅผ ์•ฝ์ฒ˜๋Ÿผ ๋Œ€ํ•˜๋Š” ํƒœ๋„๊ฐ€ ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.

์ฐธ๊ณ ๋ฌธํ—Œ: 

  1. โ€œApparent Mineralocorticoid Excess Syndromes Including Chronic Licorice Ingestion.โ€ Uptodate.com, 2021, www.uptodate.com/contents/apparent-mineralocorticoid-excess-syndromes-including-chronic-licorice-ingestion?search=licorice%20root&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1. Accessed 5 July 2021.
  2. Banasik, M., and T. Stedeford. โ€œPlants, Poisonous (Humans).โ€ Encyclopedia of Toxicology, 2014, pp. 970โ€“978, www.sciencedirect.com/science/article/pii/B9780123864543000488, 10.1016/b978-0-12-386454-3.00048-8. Accessed 5 July 2021.
  3. โ€œBRYONIA: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews.โ€ Webmd.com, 2020, www.webmd.com/vitamins/ai/ingredientmono-46/bryonia. Accessed 5 July 2021.
  4. โ€œClinical Use of St Johns Wort.โ€ Uptodate.com, 2021, www.uptodate.com/contents/clinical-use-of-st-johns-wort?search=licorice%20root&topicRef=1392&source=see_link. Accessed 5 July 2021.
  5. โ€œCorydalis.โ€ Gaia Herbs, Gaia Herbs, 12 Sept. 2018, www.gaiaherbs.com/blogs/herbs/corydalis. Accessed 5 July 2021.
  6. He, Shuaibing, et al. โ€œHerb-Induced Liver Injury: Phylogenetic Relationship, Structure-Toxicity Relationship, and Herb-Ingredient Network Analysis.โ€ International Journal of Molecular Sciences, vol. 20, no. 15, 25 July 2019, p. 3633, www.ncbi.nlm.nih.gov/pmc/articles/PMC6695972/, 10.3390/ijms20153633. Accessed 6 July 2021.
  7. โ€œHepatotoxicity due to Herbal Medications and Dietary Supplements.โ€ Uptodate.com, 2021, www.uptodate.com/contents/hepatotoxicity-due-to-herbal-medications-and-dietary-supplements?search=licorice%20root&topicRef=1392&source=see_link#H2569065065. โ€œAccessed 5 July 2021.
  8. โ€œMerriam-Webster Dictionary.โ€ Merriam-Webster.com, 2021, www.merriam-webster.com/dictionary/herb. Accessed 5 July 2021.
  9. Murphy, Patricia A., et al. โ€œInteraction of St. Johnโ€™s Wort with Oral Contraceptives: Effects on the Pharmacokinetics of Norethindrone and Ethinyl Estradiol, Ovarian Activity and Breakthrough Bleeding.โ€ Contraception, vol. 71, no. 6, June 2005, pp. 402โ€“408, pubmed.ncbi.nlm.nih.gov/15914127/#:~:text=Conclusion%3A%20St.,might%20interfere%20with%20contraceptive%20effectiveness., 10.1016/j.contraception.2004.11.004. Accessed 5 July 2021.
  10. โ€œOxford Languages and Google - English | Oxford Languages.โ€ Oup.com, 2020, languages.oup.com/google-dictionary-en/. Accessed 5 July 2021.
  11. โ€œOverview of Herbal Medicine and Dietary Supplements.โ€ Uptodate.com, 2021, www.uptodate.com/contents/overview-of-herbal-medicine-and-dietary-supplements?search=licorice%20root&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2. Accessed 5 July 2021.
  12. โ€œUSDA Plants Database.โ€ Usda.gov, 2021, plants.usda.gov/home/classification/68852. Accessed 5 July 2021.
  13. Wiart, Christophe. โ€œAlkaloids.โ€ Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases, 2014, pp. 1โ€“188, www.sciencedirect.com/science/article/pii/B9780123983732000017, 10.1016/b978-0-12-398373-2.00001-7. Accessed 5 July 2021.

๋ฉด์ฑ…์‚ฌํ•ญ:์›ฐ๋‹ˆ์Šค ํ—ˆ๋ธŒ์˜ ์ทจ์ง€๋Š” ์˜ํ•™์ ์ธ ์ง„๋‹จ์ด๋‚˜ ์น˜๋ฃŒ๋ฅผ ์ œ๊ณตํ•˜๋Š” ๊ฒƒ์ด ์•„๋‹™๋‹ˆ๋‹ค. ์ž์„ธํžˆ ์•Œ์•„๋ณด๊ธฐ